1998 B.Sc. University of Science and Technology of China (USTC).
2001 M.S. University of Science and Technology of China (USTC).
2007 PhD. Albert Einstein College of Medicine, Bronx, New York. (USA)
Postdoctoral Training
2007-2011 Research Associate.
Advisor: Robert Lefkowitz, James B. Duke Professor of Medicine and Biochemistry and Investigator, Howard Hughes Medical Institute (2012 Nobel Prize)
Honors and Awards
2014 The first prize of young scholar forum at the 11th Biochemistry and Molecualr Biology academic meeting at china.
2015 Shandong Province college scientific award, first prize for the Pharmacological research by targeting GPCR and phosphatases.
2022 C.C. Tan Life Science Innovation Award
2023 National Award for Excellence in Innovation
Personal Statement
Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand identification, physiological functions and molecular mechanism of biased signaling of GPCRs. Our first main research aspect is the identification of endogenous ligand of GPCRs.We have identified the receptor subfamily to sense the steroid hormones. For instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the progesterone and 17-hydroxyprogesterone membrane receptor are GPR126. We also identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol 2022, PNAS 2022b). By collaboration with Prof. Wei Kong, we found Nidogen as the agonist of LGR4 and the COMP is an endogenous allosteric ligand of AT1R (Circulation Research 2022, Cell Research 2021). By collaboration with Prof. Xiao Yu, we identified that Olfr109 could recognized denatured insulin and insulin fragment to control the insulin quality (Cell Metabolism 2022).Our second main research aspect is dissecting the molecular mechanism underlying sensation of force, ordor and itch by GPCRs.We have elucidate the mechanism of receptors' perception of itch, olfactory and force (Nature 2021b, 2022a, 2022b, 2023). Our third main research aspect is working mechanism of GPCR. For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking theory” etc. to explain the arrestin mediated GPCR functions (Nature communications, 2015, 2021, 2022; PNAS 2021, Molecular Pharmacology, 2017; Recommended by Faculty 1000, Nature Chemical Biology 2018). We proposed that the 10 distinct phosphorylation interacting sites along the N-terminal of arrestin is the “phospho-code” reader of the arrestin, which recognized the information passed by GPCR, then translated to more then 1000 distinct functions. Our discovery can partially explain how limited effector proteins (16 G protein subtype and 4 arrestin subtype) can translate sophisticated information dictated from more than 800 GPCR to numerous cellular functions. We identified a new mechanism in activation of ion channel by GPCRs. A prototype thinking is that the ion channels are activated by GPCRs through either direct G protein interaction or second messengers downstream of G protein activation. We identified that arrestin can mediated AT1R/TRPC3 or M3R/TRPC3 coupling by forming a complex of AT1R/β-arrestin-1/PLCγ/TRPC3 or M3R//β-arrestin-1/TRPC3 (Nature communications, 2017, Nature communications, 2018). We also identified that orphan receptor GPR64 forms complex with β-arrestin-1 and CFTR at apical membrane of efferent ductules to regulate the salt/water metabolism (eLife 2018, Faculty 1000 recommendation). These work provided new mechanisms for GPCR activated ion channel, which may be relevant to many physiological or pathological processes. Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR. We have decoded the mechanisms underlying recognition of fish oil (unsaturated fatty acids) and other lipids by GPCRs (Science 2023, Science Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell 2021), bile acids or its derivatives by GPCRs (Nature 2020).
PUBLICATIONS(#, correspondence author)
Correspondence author:
1. Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S#, Yu X#, Zhang Y#, Sun JP#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor.Science. (IF 56.9) 2023 Apr 7;380(6640):eadd6220. Correspondence author
2. Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N#, Sun JP#. Structure, function and pharmacology of human itch receptor complexes. Nature. (IF 64.8) 2021 Dec;600(7887):164-169. Correspondence author
3. Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y#, Yang F#, Li Q#, Sun JP#. Structural basis of amine odorant perception by a mammal olfactory receptor.Nature. (IF 64.8) 2023 Jun;618(7963):193-200. Correspondence author
4. Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhao FH, Zhou FL, Xi YT, Yin WH, He FD, Zhang DL, Zhu ZL, Jiang Y, Torsten Schöneberg, Ines Liebscher#, Xu H. Eric#, Sun JP#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. (IF 64.8). 2022.2022 Apr;604(7907):763-770. Correspondence author
5. Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE#, Zhang Y#, Sun JP#. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. (IF 64.8) 2021 Jan;589(7843):620-626. Correspondence author (Receive Faculty 1000 recommendation)
6. Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L#, Kong L#, Sun JP#, Yu X#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature. (IF 64.8)2022 Apr;604(7907):771-778. Correspondence author
7. Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP#, Xie X#, Yu X#, Zhang Y#. Structural basis of GPBAR activation and bile acid recognition. Nature. (IF 64.8) 2020 Nov;587(7834):499-504. Correspondence author
8. Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP#, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. (IF 64.5) 2021 Feb 18;184(4):943-956.e18. Correspondence author(Cover article, featured recommendations)
9. Yan Z, Wang JY, Yang F, Zhu KK, Wang PG, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P,Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H,Yu X #, Gao N#, Sun JP#.Cryo-EM structure of the X-linked acrogigantism-related orphan GPR101-Gs complex enabled identification of ligands with rejuvenating potential. Nat Chem Biol.(IF 14.8) 2023 accept. Correspondence author
10 Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F#, Liu Z#, Sun JP#, Yu X#. Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. Nat Chem Biol.(IF 14.8) 2022 Nov;18(11):1196-1203. Correspondence author
11. Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X,Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.(IF 14.8) Nat Chem Biol 2018 Sep;14(9):876-886. Correspondence author
12. Cheng J, Yang Z, Ge XY, Gao MX, Meng R, Xu X, Zhang YQ, Li RZ, Lin JY, Tian ZM, Wang J, Ning SL, Xu YF, Yang F, Gu JK, Sun JP#, Yu X#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metab. (IF 29.0) 2022 Feb 1;34(2):240-255.Correspondence author
13. Wang JL, Dou XD, Cheng j, Gao MX, Xu GF, Ding W, Ding JH, Li y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP#, Jiao N# and Yu X#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab. (IF 20.1) 2023 accept. Correspondence author
14. Chen Y, Mao C, Gu R, Zhao R, Li W, Ma Z, Jia Y, Yu F, Luo J, Fu Y, Sun JP#, Kong W#. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circ Res.(IF 20.1) 2022 Dec 2;131(12):1037-1054. Correspondence author
15.An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P#, Zhang P#, Yu X#, Sun JP#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proc Natl Acad Sci USA. (IF 11.1). 2022 Apr 12;119(15):e2117004119. Correspondence author
16.Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X#, Liu Z#, Yang BX#, Du Y#, Sun JP#. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc Natl Acad Sci U S A.(IF 11.1) 2023 Jul 25;120(30):e2216329120 Correspondence author
17. Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM#, Lin HC#, Yu X#, Sun JP#.Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. Proc Natl Acad Sci U S A. (IF 11.1)2021 Nov 9;118(45):e2107363118. Correspondence author
18. Qu CX,Park JY, Yun MW, He QT, Yang F, Kin K, Han D, Li R, T.M.Iverson, V V.Gurevich , Sun JP#,Chung KY#.Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. Proc Natl Acad Sci U S A. (IF 11.1)2021 Sep 14;118(37):e2026491118. Correspondence author
19. Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L#, Sun JP#, Yu X#, Zhang Y#, Zhang P#. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.Proc Natl Acad Sci U S A. (IF 11.1) 2022 Jul 19;119(29):e2117054119. Correspondence author
20. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun JP#, Kong W#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury.Cell Res. (IF 20.396) 2021 Jul;31(7):773-790. Correspondence author
21. Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. (IF 20.396) 2014 Sep;24(9):1067-90. Correspondence author (Received featured comments on contemporaneous article)
22. Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J#, Liu Z#, Yang F#, Eric Xu H#, Sun JP#. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.Nat Commun. (IF 16.6) 2023 Aug 17;14(1):5004. Correspondence author
23. He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang J#, Jin C#, Sun JP#, Yu X#. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun. (IF 13.691). 2021 Apr 22;12(1):2396. Correspondence author
25. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong W#. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.Nat Commun. (IF 13.691) 2018 Jan 2;9(1):11. Correspondence author
26. Liu CH, Gong Z, Liang Zl, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Xiao KH, Zhou Z, Yu X#, Sun JP#. Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun.(IF 13.691) 2017 Feb 9;8:14335.Correspondence author(Received feature reviews from Channels, Channels (Austin). 2017 May 1:1-3.)
27. Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#.Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR.Nat Commun. (IF 13.691)2015 Sep 8;6:8202. Correspondence author (Receive Faculty 1000 referrals)
29. Dong JH, WangYJ, CuiM, WangXJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, LiXY, LinA, KahsaiA, Cahill IIIT, ChenZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry.(IF 12.069) 2017 Apr 15;81(8):654-670.Correspondence author (Receive Faculty 1000 Recommendations, cover article)
30. Qu CX, Mao CY, Xiao P, Shen QY, Zhong YN, Yang F, Shen DD, Tao XN, Zhang HB, Yan X, Zhao RJ, He JY, Guan Y, Zhang C, Hou GH, Zhang PJ, Hou GG, Li ZJ, Yu X, Chai RJ#, Guan YF, Sun JP#, Zhang Y#. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2 (EP2).Science Advances (IF 13.116) 2021 Apr 2;7(14):eabf1268. Correspondence author
31. Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM#, Sun JP#, Xu ZG#. Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment. Adv Sci (Weinh). (IF 15.1) 2023 Jun;10(16):e2205993. Correspondence author
32. Lin JY, Cheng J, Du YQ, Pan W, Zhang Z, Wang J, An J, Yang F, Xu YF, Lin H, An WT, Wang J, Yang Z, Chai RJ, Sha XY, Hu H.L#,Sun JP#, Yu X#. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discov. (IF 10.56)2020 Apr 7;6:20.Correspondence author
33. Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun JP#, Sun HY#. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials. (IF 12.47) 2017 Sep;140:220-229.Correspondence author
35. Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12.Cell Reports (IF 8.816). 2016 May 10;15(6):1345-58. Correspondence author
36. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#.Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.Elife. (IF 8.508)2018 Feb 2;7:e33432. Correspondence author
37. Xu YF, Chen X, Yang Z, Xiao P, Liu CH, Li KS, Yang XZ, Wang YJ, Zhu ZL, Xu ZG, Zhang S, Wang C, Song YC, Zhao WD, Wang CH, Ji ZL, Zhang ZY, Cui M#, Sun JP#, Yu X#. (2021) PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.EMBO Reports. 2021, vol. 22,5 (2021): e52141. ( IF 8.80 )Correspondence author
38. Yang Z, Cheng J, Shang P, Sun JP#, Yu X. Emerging roles of olfactory receptors in glucose metabolism. Trends Cell Biol.(IF 19.0) 2023 Jun;33(6):463-476. Correspondence author
39. Huang S, Xiao P,Sun JP#. Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduct Target Ther. (IF 13.195)2020 Jul 21;5(1):127. Correspondence author
40. Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Cui M, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia. (IF 6.871) .2014 Sep;57(9):1899-910 Correspondence author
41. Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J. Med Chem. (IF 6.521). 2014 Nov 26;57(22):9309-22. Correspondence author
42. Huang SM, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X,Sun JP#, Wang J#. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET.Anal Chem.2019 Dec 3;91(23):14936-14942. (IF 6.642) Correspondence author
43. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X#. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem.(IF 4.297) 2019 May 24;294(21):8653-8663. Correspondence author
44. Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A,Wang C, Yu X, Wu JW#,Sun JP#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem. (IF 4.297) 2018 Oct 19;293(42):16226-16241.Correspondence author
45. Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem. (IF 4.863)2014 Aug 29;289(35):24215-25. Correspondence author
46. Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY# Structural Mechanism of the Arrestin-3/JNK3 Interaction.Structure. (IF 4.831) 2019 Apr 16. 27(7):1162-1170.e3. Correspondence author
47. Gong Q, Qin W, Xiao P, Wu X, Li L#, Zhang G, Zhang R, Sun JP#, Yao SQ#, Huang W#. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb). (IF 5.989) 2019 Dec 17;56(1):58-61. Correspondence author (Cover article)
48. Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#,Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells.Br J Pharmacol. (IF 6.148) 2015 Nov;172(21):5050-67. Correspondence author
49. Zhang D, Wang Y, Lin H, Sun Y, Wang M, Jia Y, Yu X, Jiang H, Xu W,Sun JP#, Xu Z#Function and therapeutic potential of G protein-coupled receptors in epididymis.Br J Pharmacol. (IF 6.148) 2020 Dec;177(24):5489-5508. Correspondence author
50. Liu J, Li QX, Wang XJ, Zhang C, Duan YQ, Wang ZY, Zhang Y, Yu X, Li NJ,Sun JP#, Yi F#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.Cell Death Dis. (IF 6.486). 2016 Apr 7;7(4):e2183. Correspondence author
51. Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model.Mol Pharmacol. (IF 3.904) 2017 Sep;92(3):201-210. Correspondence author (Cover article)
52. Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z,Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. (IF 5.384) .2018 Jan;32(1):73-82. Correspondence author
53. Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#.The catalytic role of the M2 metal ion in PP2Cα.Sci Rep.(IF 5.597)2015 Feb 24;5:8560. Correspondence author
54. Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#, Sun JP#The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. IJBCB.(IF 4.595) 2014 Dec;57:84-95. Correspondence author
55. Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP#Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors.Journal of Neurochemistry. (IF 4.371) 2014 Dec;131(6):699-711. Correspondence author
56. Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). Journal of Neurochemistry. (IF 4.371) 2014 Jan;128(2):315-329. Correspondence author (Receive Faculty 1000 recommendation)
57. Dolatabad MR, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Liu HD, Shen YM, Yu X, Sun JP#, Zhang PJ#Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem. (IF 4.371) 2019 Feb;148(4):550-560. Correspondence author
58.Sun JP#, Zhang D, Wang Y, Lin H, Yu X, Xu Z#. The role of G protein-coupled receptors in cochlear planar cell polarity.Int J Biochem Cell Biol. (IF 4.172)2016 Aug;77(Pt B):220-5. Correspondence author and First author
59. Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP#. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem. (IF 3.113) 2015 Dec;10(12):1980-7.Correspondence author
60. Liu HD, Wang WB, Xu ZG#, Liu CH, He DF, Du LP, Li MY, Yu X#,Sun JP#. FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies. Eur J Pharmacol. (IF 3.266) 2015 Sep 15;763(Pt B):160-8. Correspondence author
61. Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#,Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Scientific Reports.(IF 4.57)2013;3:2333. Correspondence author
62. Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X,Sun JP#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. Future Med Chem.(IF 4.065) 2015 Dec;7(18):2429-37. Correspondence author
63. Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase. FEBS J. (IF 4.267) 2013 Jun;280(11):2700-11. Correspondence author
64. Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ#, Fang H#,Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase.Bioorg Med Chem Lett.(IF2.427)2016 Oct 1;26(19):4795-8. Correspondence author
65. Sun JP*#, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci. (IF 2.662)2013 May;50(1):204-14. Correspondence author and First author
66. Xiao P, Yang L, Zhang C, Wang JY#, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB (IF 0.301)2012, 39(11): 1050-1060. Correspondence author
67. Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#. Beta2-Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci. (IF 2.662) 2012 Oct;48(2):456-63. Correspondence author
68. Zhao S, Guo S, Yang C, Gong Z, Wang YM, Jia YL, Jiang XY, Xu LW, Shi L, Yu X, Sun JP#., Zhang Y#., Chen X#.Cell active and functionally-relevant small-molecule agonists of calcitonin receptor.Bioorg Chem. (IF 5.1) 2020 Mar;96:103596. Correspondence author
69. Sun Y, Zhang D, Ma ML, Lin H, Song Y, Wang J, Ma C, Yu K, An W, Guo S, He D, Yang Z, Xiao P, Hou G, Yu X#., Sun JP#.Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.J Biol Chem.(IF 4.237)2021 Jan;296:100174. Correspondence author
70. Lin JY, Yang Z, Yang C, Du JX, Yang F, Cheng J, Pan W, Zhang SJ, Yan X, Wang Jia, Wang Jin, Tie L, Yu X#, Chen X#, Sun JP#. An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors.J Biol Chem.(IF 4.237)2021 Oct;297(4):101160.Correspondence author
71. Pei Y, Wen X, Guo SC, Yang ZS, Zhang R, Xiao P, Sun JP#. Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.Biochem Biophys Res Commun.(IF 3.1)2023 Sep 3;671:327-334. Correspondence author
72. Lu R, Yan X, Fang G, Zhuang Y, Guo L, Zhang C, Wu X, Xiao P, Cao Y, Yang F, Yu X, Sun JP#, Zhou JY#. A molecular mechanism of UDCA engagement with GPBAR and subsequent G protein interaction revealed by scattered alanine scanning. Biochem Biophys Res Commun. (IF 3.1) 2022 Apr 16;600:14-21 Correspondence author
First author and Co-autors:
1. X Yu*, Sun JP*, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A. (IF 11.1)2007 Dec 11;104(50):19767-72. Co-first author
2. Sun JP*, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem. (IF 4.8) 2003 Apr 4; 278(14): 12406-14. First author
3. Sun JP*, Luo Y*, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem. (IF 4.8) 2007 Sep 28;282(39):29043-51. Co-first author
4. Sun JP*, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor.J Biol Chem. (IF 4.8)2003 Aug 29; 278(35): 33392-9. First author
6. Sun JP*, Wang WQ*, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion.Biochemistry. (IF 2.9)2005 Sep 13; 44(36):12009-21. Co-first author
8. Kahsai AW, Rajagopal S, Sun JP, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols. (IF 14.8) 2014 Jun;9(6):1301-19.
9. Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.Proc Natl Acad Sci U S A. (IF 11.1). 2017 Mar 7;114(10):2562-2567.
10. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. (IF 15.9). 2017 Jun 30;127(7):2631-2646.
16. Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q#, Yu X#. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE. (IF 4.6) 2012;7(8):e43631. Epub 2012 Aug 27
17. Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X#. Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol. (IF 4.0); 2011 0363-6143 1522-1563
18. Kahsai AW, Xiao K#, Rajagopal S, Ahn S, Shukla AK, Sun JP, Oas TG, Lefkowitz RJ#. Multiple ligand-specific Conformations of the β2-Adrenergic Receptor, Nature Chemical Biology; (IF 16.1). 2011 Aug 21; 7(10):692-700.
19. Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, and Zhang ZY#. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem. (IF 5.6) 2011 Sep 2;286(35):30526-34.
20. Xiao K, Sun JP, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP#, Lefkowitz RJ#. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. USA. (IF 10.6) 2010 Aug 107(34), 15299-15304.
21. Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica. (IF 1.1) 2010 April, 25: 163-170
22. Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor.Nature Biotechnology. (IF 42.3) 2008 Feb;26(2):189-91.
23. Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor.Molecular Pharmacology. (IF 4.9) 2008 May; 73(5): 1333-8.
24. Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY#. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation.J Biol Chem. (IF 5.6)2007 Feb 23;282(8):5413-9.
25. Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.Proc Natl Acad Sci U S A. (IF 10.6). 2006 Apr 4; 103(14):5326-31.
26. Wang WQ, Sun JP, Zhang ZY. An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem. (IF 4.3)2003; 3(7): 739-48.
27. Liu S, Zhu Z, Sun JP, Zhu Z, Huang Q, Teng M, Niu L. Purification, crystallization and preliminary X-ray crystallographic analysis of agkaggregin, a C-type lectin-like protein from Agkistrodon acutus venom.Acta Crystallogr D Biol Crystallogr. (IF 5.3) 2002 Apr; 58(Pt 4): 675-8.
30. Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P,Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B,Scott KL, Hilsenbeck SG, Sun JP, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer .Nature Medicine. (IF 36.2) 2018 May;24(4):505-51
36. Hou X,Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H.Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase by Targeting Computationally Revealed Cryptic Pockets. Eur J Med Chem. (IF 5.6) 2020 Mar 15;190:112131.
40. Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun JP, Lv P, Zhang H, Wang C. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Front Cell Neurosci. (IF 5.57) 2021 Jun 16;15:658586.
41. Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y. S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nat Commun. (IF 15.8) 2021 Jul 22;12(1):4452.
42. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun JP, Zhou Y, Cui Q, Fu Y, Kong W. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. (IF 27.47) 2021 Jul 28.144(15):1244-1261.
43. Zhang GH, Li DY, Tu CF, Meng LL, Tan YQ, Ji ZL, Cheng J, Lu GX, Lin G, Zhang H, Sun JP, Wang M, Du J#, Xu W#. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Hum Mol Genet.(IF 6.13)2021 Aug 20;ddab234.
44. Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW#, Zhang Y#. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. (IF 25.92) 2021 Aug 25.
45. Jia Y, Zhang L, Liu ZY, Mao CF, Ma ZH, Li WQ, Yu F, Wang YB, Huang YQ, Zhang WZ, Zheng JG, Wang X, Xu QB, Zhang J, Feng W, Yun CH, Liu CJ, Sun JP, Fu Y, Cui QH#, Kong W#.Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.Cell Discov.(IF 33.5) 2022 Mar 1;8(1):21.
46. Du YQ, Sha XY, Cheng J, Wang J, Lin JY, An WT, Pan W, Zhang LJ, Tao XN, Xu YF, Jia YL, Yang Z, Xiao P, Liu M, Sun JP, Yu X#.Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents.Diabetes.(IF 7.7) 2022 Jul 1;71(7):1454-1471.
47. Zhao LH#, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun JP, Melcher K, Zhang Y, Yu X#, Xu HE#.Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.Nat Commun.(IF 16.6) 2022 Nov 5;13(1):6670.
48. Lin X, Chen B, Wu YR, Han YQ, Qi A, Wang JY, Yang Z, Wei XH, Zhao TT, Wu LJ, Xie X, Sun JP, Zheng J#, Zhao SW#, Xu F#.Cryo-EM structures of orphan GPR21 signaling complexes.Nat Commun.(IF 16.6) 2023 Jan 13;14(1):216.
49. Wang H, Du H, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z#, Lu Q#.Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation.Nat Commun.(IF 16.6) 2023 Mar 24;14(1):1657.
50. Cai Z, Xie N, Gong Z, Yang Z, Lin F, Li Z, Dai R, Chen Y, Zhang S, Zhu S, Zhou S, Lin J, Yu F, Liu L, Sun JP, Zhou J, Li W, Xiong C, Fu Y, Cong X#, Kong W#. Activin Receptor-Like Kinase 3 Directly Couples Gαq (Guanine Nucleotide-Binding Protein Subunit αq)/ Gαq (Guanine Nucleotide-Binding Protein Subunit α11) to Regulate Vascular Contractility.Hypertension.(8.3) 2023 Jun;80(6):1231-1244.
51. Zhao L, Liu J, Li K, Zhang C, Chen T, Liu Z, Tang Y, Hu X, Shi A, Shu L, Huang S, Lian S, Zhang M, Li H, Sun JP, Yu X, Zhang Z, Zhang Z, Xu Y. PTPN9 dephosphorylates FGFR2pY656/657 via interaction with ACAP1 and ameliorates pemigatinib effect in cholangiocarcinoma. Hepatology.(IF 13.5) 2023 Jul 27.Online ahead of print.
52. Jia M, Li L, Chen R, Du J, Qiao Z, Zhou D, Liu M, Wang X, Wu J, Xie Y, Sun Y, Zhang Y, Wang Z, Zhang T, Hu H, Sun JP, Tang W#, Yi F#. Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.Mol Ther.(IF 12.4) 2023 Jul 14:S1525-0016(23)00387-8.
53. Jin S, Lin C, Wang Y, Wang H, Wen X, Xiao P, Li X, Peng Y, Sun JP, Lu YY#, Wang XH#. Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2. J Med Chem. (IF 7.3)2023 Aug 2. Online ahead of print.
54. Du YQ, Sha XY, Cheng J, Wang J, Lin JY, An WT, Pan W, Zhang LJ, Tao XN, Xu YF, Jia YL, Yang Z, Xiao P, Liu M, Sun JP, Yu X#. Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents. Diabetes. (IF 7.7)2022 Jul 1;71(7):1454-1471.
51.Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu, Fan Yang, …JP Sun. Structural basis of amine odorant perception by a mammal olfactory receptor. Narure (IF 64.5) 2023 May 24.
52. Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang,Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You,Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong,Shengxuan Peng, Yuan Liu, ChuanzhengWang, Xin Luo1, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou , Zhongmin Liu, Fan Yang , H. Eric Xu, Jin-Peng Sun. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commu.(IF 16.6) 2023 Aug. 17.
Sun JP (2004) Structure Basis of Specific Inhibition of Yersinia Protein-tyrosine Phosphatase 2004ASBMB annual Meeting, Boston. (Selected honored student talk)
Sun JP (2011) Dissecting Ligand Specific Severn Trans-membrane Receptor Signaling Complexes 2011 BIT's 3rd International Congress of Antibodies March 23 Track 2-1
孙金鹏 (2011) PEST蛋白质酪氨酸磷酸酶底物特异性的分子基础第十届全国酶学学术讨论会
孙金鹏 (2012) GPCR的工作原理,解读2012年诺贝尔化学奖内蒙古大学
Sun JP (2012) Decoding the HER2 C-terminal tyrosine phosphorylation barcode. Symposium of receptors, associated to 2012 Nobel Chemistry Prize.
孙金鹏 (2014) G蛋白偶联受体的偏向性信号转导北京大学化学与生物技术学院(深圳)
孙金鹏 (2014) PEST domain containing phosphatases. 中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议青年科学家论坛(厦门),并获得一等奖
Sun JP (2014) Regulation of the islet homeostasis by β-adrenergic receptors. (Xiamen) The 4th Workshop on the Hippo pathway
孙金鹏(2015):G蛋白偶联受体的磷酸化编码介导的信号转导机制 (Phospho-decision mechanism of specific arrestin conformations and functions: The music of the receptor revealed by unnatural amino acid incorporation and 19F-NMR) 泛环渤海生物化学与分子生物学会,专题报告
孙金鹏(2015): G蛋白偶联受体的磷酸化编码 (Phospho-barcoding of the GPCRs). 第九届全国化学生物学会议,邀请报告
Sun JP(2017)A new connection between the GPCR and channel through arrestin. 19th International Symposium on Chromaffin Cell Biology
Sun JP(2017)Biased GPCR signaling in the drug development 首届中国大连受体会议
Sun JP(2017)靶向GPCR偏向性途径的肾脏病药物发现第一届全国肾脏药理学学术会议
Sun JP(2017)Mechanism of GPCR phospho-coding and its application in new drug discovery 2017 Asian Federation for Pharmaceutical Sciences Conference (AFPS2017)
Sun JP(2017)听觉中G蛋白偶联受体的相关研究第十五届中国生物物理年会,听觉分会
Sun JP(2017)Arrestin mediated GPCR biased signaling and its application in new drug discovery The 2nd CNPHARS-ASPET Joint Symposia on Pharmacology第二届中-美药理学双边学术会议
回国后作为通讯作者发表的论文
1. Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhao FH, Zhou FL, Xi YT, Yin WH, He FD, Zhang DL, Zhu ZL, Jiang Y, Torsten Schöneberg, Ines Liebscher#, Xu H. Eric#, Sun JP#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature(IF 46.486). 2022.2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y.通讯作者
2. Xiao P, Guo SC, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Li SL, Tao XN, Yang ZS, Lu Y, He JY, Wang CX, Zhang L#, Kong LL#, Sun JP#, Yu X#. Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4. Nature(IF 46.486). 2022 Apr;604(7907):771-778. doi: 10.1038/s41586-022-04590-8.通讯作者
3. Cheng J, Yang Z, Ge XY, Gao MX, Meng R, Xu X, Zhang YQ, Li RZ, Lin JY, Tian ZM, Wang J, Ning SL, Xu YF, Yang F, Gu JK, Sun JP#, Yu X#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metablism(IF 27.28). 2022. 通讯作者(同期preview专题评论)
4. An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P#, Zhang P#, Yu X#, Sun JP#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.Proc Natl Acad Sci USA.(IF 11.21). 2022 Apr 12;119(15):e2117004119.doi: 10.1073/pnas.2117004119.通讯作者
5. Yang F, Guo LL, Li Y, Wang GP, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu CX, Xu YF, Xiao P, Zhu ZL, Li ZJ, Zhou JY, Yu X, Gao N#, Sun JP#. Structure, function and pharmacology of human itch receptor complexes. Nature(IF 46.486). 2021. 通讯作者
6. Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE#, Zhang Y#, Sun JP#. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.Nature(IF 46.486). 2021 Jan;589(7843):620-626. 通讯作者(获得Faculty 1000推荐)
7. Yang F, Mao C, Guo LL, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C,Sun JP#, Xie X#, Yu X#, Zhang Y#. Structural basis of GPBAR activation and bile acid recognition.Nature(IF 46.486). 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1.通讯作者
8. Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu CX, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu, Yang S, Daniel M. Rosenbaum, Sun JP#, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell(IF 38.620). 2021 Feb; doi:10.1016/j.cell.2021.01.028. 通讯作者(封面文章,专题推荐)
9. Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X,Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.(IF 13.99)Nat Chem Biol2018 Sep;14(9):876-886. 通讯作者
10. Liu CH; Gong Z; Liang Zl; Liu ZX, Yang F, Sun YJ; Ma ML; Wang YJ; Xiao KH; Zhou Z; Yu X; Sun JP#; Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling Nature communications. (IF 13.691) 2017 Feb 9;8:14335. doi: 10.1038/ncomms14335.通讯作者(获得Channels杂志的专题评论,Channels (Austin). 2017 May 1:1-3.)
11. Dong JH, WangYJ, CuiM, WangXJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, LiXY, LinA, KahsaiA, Cahill IIIT, ChenZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry.(IF 12.069) 2017 Apr 15;81(8):654-670.通讯作者(获得Faculty 1000推荐,封面文章)
13. Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR. Nature Communications. (IF 13.691)08 Sep 2015doi:10.1038/ncomms9202通讯作者(获得Faculty 1000推荐)
14. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong Wei#. Direct Interaction and Dual Roles of Homocysteine on theAngiotensin II Type 1 Receptor in the Aggravation of Vascular Injury. Nature Communications(IF 13.691). 2018 Jan 2;9(1).
15. He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang JY#, Jin CW#, Sun JP#, Yu X#. Structures of arrestin2 bound to different phospho-barcodes and NMR characterization using DeSipher revealed the mechanism underlying the phospho-interaction-pattern-selective functions of arrestin.Nature Communications (IF 13.691). 2021, Accepted. 通讯作者
16. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun JP#,, Kong W#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res.(IF 20.396)2021 Jan 28. doi: 10.1038/s41422-020-00464-8.
17. Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. (IF 20.396)2014 Sep;24(9):1067-90. 通讯作者 (获得同期文章的专题评论)
18. Qu CX, Mao CY, Xiao P, Shen QY, Zhong YN, Yang F, Shen DD, Tao XN, Zhang HB, Yan X, Zhao RJ, He JY, Guan Y, Zhang C, Hou GH, Zhang PJ, Hou GG, Li ZJ, Yu X, Chai RJ#, Guan YF, Sun JP#, Zhang Y#. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2 (EP2). Science Advances (IF 13.116) 2021 Jan 12. doi: 通讯作者
20. Qu CX,Park JY, Yun MW, He QT, Yang F, Kin K, Han D, Li R, T.M.Iverson, V V.Gurevich , Sun JP#,Chung KY#.Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.Proc Natl Acad Sci U S A(IF 11.20). 2021 Sep 6 Vol. 118 通讯作者
21. Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM#, Lin HC#, Yu X#, Sun JP#.Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.Proc Natl Acad Sci U S A(IF 11.20). 2021 Sep 23 通讯作者
22. Lin JY, Cheng J, Du YQ, Pan W, Zhang Z, Wang J, An J, Yang F, Xu YF, Lin H, An WT, Wang J, Yang Z, Chai RJ, Sha XY, Hu H.L#,Sun JP#, Yu X#. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discov. (IF 10.56)2020 Apr 7;6:20.通讯作者
23. Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun J#, Sun H#. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials. (IF 12.47)2017 Sep;140:220-229.通讯作者
25. Huang S, Xiao P,Sun J#. Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduct Target Ther.(IF 13.195)2020 Jul 21;5(1):127. 通讯作者
26. Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12.Cell Reports (IF 8.816). 2016 May 10;15(6):1345-58.通讯作者
27. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#.Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife. (IF 8.508) 2018 Feb 2;7. pii: e33432. doi: 10.7554/eLife.33432.
28. Xu YF*#, Chen X#, Yang Z, Xiao P, Liu CH, Li KS, Yang XZ, Wang YJ, Zhu ZL, Xu ZG, Zhang S, Wang C, Song YC, Zhao WD, Wang CH, Ji ZL, Zhang ZY, Cui M*, Sun JP*, Yu X*. (2021) PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. EMBO Reports. 2021, vol. 22,5 (2021): e52141. ( IF 8.80 )通讯作者
29. Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia. (IF 6.871) .2014 Sep;57(9):1899-910. doi: 10.1007/s00125-014-3290-0.通讯作者
30. Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of N
30. Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J. Med Chem. (IF 6.521). 2014 Nov 26;57(22):9309-22 PMID: 25372368. 通讯作者
31. Huang SM(#), Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X,Sun JP#, Wang J#. A Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem.2019 Oct 31. doi: 10.1021/acs.analchem.9b03305. (IF 6.642)
32. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X# Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem.(IF 4.297)2019 May 24;294(21):8653-8663.通讯作者
33. Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A, Yu X, Wu JW#,Sun J#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem. (IF 4.297)2018 Oct 19;293(42):16226-16241.通讯作者
34. Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem. (IF 4.863)2014 Aug 29;289(35):24215-25. 通讯作者
35. Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY#Structural Mechanism of the Arrestin-3/JNK3 Interaction.Structure.(IF 4.831) 2019 Apr 16. pii: S0969-2126(19)30124-8. 通讯作者
36. Gong Q*, Qin W*, Xiao P*, Wu X, Li L#, Zhang G, Zhang R, Sun J#, Yao SQ#, Huang W#. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb).(IF 5.989)2019 Nov 6. doi: 10.1039/c9cc07680h. 通讯作者(封面文章)
37. Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#,Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells. Br J Pharmacol. (IF 6.148). 2015 Nov;172(21):5050-67.通讯作者
38. Zhang D, Wang Y, Lin H, Sun Y, Wang M, Jia Y, Yu X, Jiang H, Xu W,Sun J#, Xu Z Function and therapeutic potential of GPCRs in epididymis.Br J Pharmacol.(IF 6.148). 2020 Sep 9. doi: 10.1111/bph.15252通讯作者
39. J Liu, QX Li, XJ Wang, C Zhang, YQ Duan, ZY Wang, Y Zhang, X Yu, NJ Li, JP Sun#,F Yi#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.Cell Death and Disease(IF 6.486)(2016)Apr 7;7: e2183; doi:10.1038/cddis.2016.89.通讯作者
40. Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol.(IF 3.904) 2017 Feb 28. pii: mol.116.107839. (封面文章)
41. Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. (IF5.394)2018 Jan;32(1):73-82.
42. Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#.The catalytic role of the M2 metal ion in PP2Cα.Sci Rep.(IF5.597)2015 Feb 24;5:8560. doi: 10.1038/srep08560. 通讯作者
43. Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#,Sun JP#The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. IJBCB. (IF 4.595) 2014, 57 Dec, 84-95. 通讯作者
44. Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP#Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors.Journal of Neurochemistry.(IF 4.371) 2014 Dec;131(6):699-711. 通讯作者
45. Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). Journal of Neurochemistry. 2014 Jan;128(2):315-29. (IF 4.371) 通讯作者(获得Faculty 1000推荐)
46. Rostaminasab Dolatabad M, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Hong-da L, Shen YM, Yu X, Sun JP#, Zhang PJ# Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem. (IF 4.371)2019 Feb;148(4):550-560.
47. Sun J#, Zhang D, Wang Y, Lin H, Yu X, Xu Z. The Role of G Protein-coupled Receptors in Cochlear Planar Cell Polarity. Int J Biochem Cell Biol.(IF 4.172)2016 Aug;77(Pt B):220-5.通讯作者兼第一作者
48. Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP# Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem(IF 3.113) 2015 Dec;10(12):1980-7. 通讯作者
49. Liu HD, Wang WB, Xu ZG, Liu CH, He DF, Du LP, Li MY, Yu X,Sun JP#. G protein-coupled receptor 120:A hot target for the development of anti-diabetic therapies. Eur J Pharmacol. (IF 3.266)2015 Sep 15;763(Pt B):160-8. 通讯作者
50. Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#,Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Scientific Reports. (IF 4.576)2013;3:2333. 通讯作者
51. Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X,Sun J#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics . Future Med Chem.(IF 4.065)2015 Dec;7(18):2429-37. 通讯作者
52. Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. PPM1A functions as an ERK phosphatase. FEBS J. (IF 4.267)2013 Jun;280(11):2700-11. 通讯作者
53. Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ, Fang H,Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase.Bioorg Med Chem Lett.(IF2.427)2016 Oct 1;26(19):4795-8.通讯作者
54. Sun JP*#, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci.(IF 2.662) 2013 May;50(1):204-14. 通讯作者兼第一作者55. Xiao P, Yang L, Zhang C, Wang JY, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB (IF 0.301)2012, 39(11): 1050-1060. 通讯作者
56. Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#. Beta2- Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci. (IF2.662)2012 Oct;48(2):456-63. 通讯作者
57. Zhao S, Guo S, Yang C, Gong Z, Wang Y, Jia Y, Jiang X, Xu L, Shi L, Yu X, Sun J#., Zhang Y#., Chen X#. Cell active and functionally-relevant small-molecule agonists of calcitonin receptor.Bioorg Chem. 2020 Jan 21;96:103596. doi: 10.1016/j.bioorg.2020.103596.v (IF 4.567)通讯作者
58. Sun Y, Zhang D, Ma ML, Lin H, Song Y, Wang J, Ma C, Yu K, An W, Guo S, He D, Yang Z, Xiao P, Hou G, Yu X#., Sun JP#. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. J Biol Chem.(IF 4.237)2020 Dec 10 RA120.014726. 通讯作者
第一作者及共同作者发表文章
1. X Yu*, Sun JP*, Y He, X Guo, S Liu, B Zhou, A Hudmon, ZY Zhang. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.Proc. Natl. Acad. Sci. USA. (IF 10.6)2007 Dec, 104, 19767-19772. Comment/ Reviews on this paper: http://www.f1000biology.com/article/1098405/evaluation共同第一作者
2. Sun JP*, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem. (IF 5.6) 2003 Apr 4; 278(14): 12406-14. 第一作者
3. Sun JP*, Luo Y*, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem. (IF 5.6) 2007 Sep 28;282(39):29043-51. 第一作者
4. Sun JP*, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor.J Biol Chem. (IF 5.6)2003 Aug 29; 278(35): 33392-9.第一作者
6. Sun JP*, Wang WQ*, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion.Biochemistry. (IF 3.4)2005 Sep 13; 44(36):12009-21. 共同第一作者
8. Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols. (IF 13.6) 2014 Jun;9(6):1301-19.
9. Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.Proc Natl Acad Sci U S A. (IF 10.6). 2017 Mar 7;114(10):2562-2567.
10. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. (IF 14.4). 2017 Jun 30;127(7):2631-2646.
16. Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q, Yu X. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE. (IF 4.6) 2012;7(8):e43631. Epub 2012 Aug 27
17. Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol. (IF 4.0); 2011 0363-6143 1522-1563
18. Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ Multiple ligand-specific Conformations of the β2-Adrenergic Receptor, Nature Chemical Biology; (IF 16.1). 2011 Aug 21; 7(10):692-700.
19. Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, and Zhang ZY Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem. (IF 5.6) 2011 Sep 2;286(35):30526-34.
20. Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. USA. (IF 10.6) 2010 Aug 107(34), 15299-15304.
21. Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica. (IF 1.1) 2010 April, 25: 163-170
22. Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor.Nature Biotechnology. (IF 42.3) 2008 Feb;26(2):189-91.
23. Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor.Molecular Pharmacology. (IF 4.9) 2008 May; 73(5): 1333-8.
24. Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation.J Biol Chem. (IF 5.6)2007 Feb 23;282(8):5413-9.
25. Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.Proc Natl Acad Sci U S A. (IF 10.6). 2006 Apr 4; 103(14):5326-31.
26. Wang WQ, Sun JP, Zhang ZY. An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem. (IF 4.3)2003; 3(7): 739-48.
27. Liu S, Zhu Z, Sun J, Zhu Z, Huang Q, Teng M, Niu L. Purification, crystallization and preliminary X-ray crystallographic analysis of agkaggregin, a C-type lectin-like protein from Agkistrodon acutus venom.Acta Crystallogr D Biol Crystallogr. (IF 5.3) 2002 Apr; 58(Pt 4): 675-8.
30. Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Targeting receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer. Nature Medicine. (IF 36.2) 2018 May;24(4):505-51
36. Hou X, Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H.Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase by Targeting Computationally Revealed Cryptic Pockets. Eur J Med Chem. (IF 5.6) 2020 Mar 15;190:112131.
46.. Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun J, Lv P, Zhang H, Wang C. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Front Cell Neurosci. (IF 5.57) 2021 Jun 16;15:658586.
47. Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y. S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nat Commun. (IF 15.8) 2021 Jul 22;12(1):4452.
48. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. (IF 27.47) 2021 Jul 28.
49. Zhang G, Li D, Tu C, Meng L, Tan Y, Ji Z, Cheng J, Lu G, Lin G, Zhang H, Sun J, Wang M, Du J, Xu W. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Hum Mol Genet.(IF 6.13)2021 Aug 20;ddab234.
50. Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. (IF 25.92) 2021 Aug 25.
51.Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu, Fan Yang, …JP Sun. Structural basis of amine odorant perception by a mammal olfactory receptor. Narure (IF 64.5) 2023 May 24.
52. Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang,Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You,Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong,Shengxuan Peng, Yuan Liu, ChuanzhengWang, Xin Luo1, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou , Zhongmin Liu, Fan Yang , H. Eric Xu, Jin-Peng Sun. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commu.(IF 16.6) 2023 Aug. 17.