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孙金鹏(Jinpeng Sun)
作者:  来源:  发布时间:2018年11月28日 09:52  浏览次数:

 

 



Jinpeng Sun


Ph.D,

Professor and Executive Dean, Advanced Medical College;

Shandong University School of Medicine

Joint Professor,

Department of Physiology, School of Medicine, Peking University

44 Wenhua Xi Road, Building 6, 6408; Jinan 250012; China

Phone (office): 086-531-88381910

Phone (cell): 15966613591

Email: sunjinpeng@sdu.edu.cn or sunjinpengsdu@126.com

 

Education

 

1998 B.Sc. University of Science and Technology of China (USTC).

2001 M.S. University of Science and Technology of China (USTC).

2007 PhD. Albert Einstein College of Medicine, Bronx, New York. (USA)

 

Postdoctoral Training

 

2007-2011 Research Associate.

Advisor: Robert Lefkowitz, James B. Duke Professor of Medicine and Biochemistry and Investigator, Howard Hughes Medical Institute (2012 Nobel Prize)

 

Honors and Awards

 

2014 The first prize of young scholar forum at the 11th Biochemistry and Molecualr Biology academic meeting at china.

2015 Shandong Province college scientific award, first prize for the Pharmacological research by targeting GPCR and phosphatases.

2022 C.C. Tan Life Science Innovation Award

2023 National Award for Excellence in Innovation

 

Personal Statement

    Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand identification, physiological functions and molecular mechanism of biased signaling of GPCRs. Our first main research aspect is the identification of endogenous ligand of GPCRs. We have identified the receptor subfamily to sense the steroid hormones. For instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the progesterone and 17-hydroxyprogesterone membrane receptor are GPR126. We also identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol 2022, PNAS 2022b). By collaboration with Prof. Wei Kong, we found Nidogen as the agonist of LGR4 and the COMP is an endogenous allosteric ligand of AT1R (Circulation Research 2022, Cell Research 2021). By collaboration with Prof. Xiao Yu, we identified that Olfr109 could recognized denatured insulin and insulin fragment to control the insulin quality (Cell Metabolism 2022). Our second main research aspect is dissecting the molecular mechanism underlying sensation of force, ordor and itch by GPCRs. We have elucidate the mechanism of receptors' perception of itch, olfactory and force (Nature 2021b, 2022a, 2022b, 2023). Our third main research aspect is working mechanism of GPCR. For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking theory” etc. to explain the arrestin mediated GPCR functions (Nature communications, 2015, 2021, 2022; PNAS 2021, Molecular Pharmacology, 2017; Recommended by Faculty 1000, Nature Chemical Biology 2018). We proposed that the 10 distinct phosphorylation interacting sites along the N-terminal of arrestin is the “phospho-code” reader of the arrestin, which recognized the information passed by GPCR, then translated to more then 1000 distinct functions. Our discovery can partially explain how limited effector proteins (16 G protein subtype and 4 arrestin subtype) can translate sophisticated information dictated from more than 800 GPCR to numerous cellular functions. We identified a new mechanism in activation of ion channel by GPCRs. A prototype thinking is that the ion channels are activated by GPCRs through either direct G protein interaction or second messengers downstream of G protein activation. We identified that arrestin can mediated AT1R/TRPC3 or M3R/TRPC3 coupling by forming a complex of AT1R/β-arrestin-1/PLCγ/TRPC3 or M3R//β-arrestin-1/TRPC3 (Nature communications, 2017, Nature communications, 2018). We also identified that orphan receptor GPR64 forms complex with β-arrestin-1 and CFTR at apical membrane of efferent ductules to regulate the salt/water metabolism (eLife 2018, Faculty 1000 recommendation). These work provided new mechanisms for GPCR activated ion channel, which may be relevant to many physiological or pathological processes. Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR. We have decoded the mechanisms underlying recognition of fish oil (unsaturated fatty acids) and other lipids by GPCRs (Science 2023, Science Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell 2021), bile acids or its derivatives by GPCRs (Nature 2020).

 

PUBLICATIONS (#, correspondence author)

 

Correspondence author:


1.  Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S#, Yu X#, Zhang Y#, Sun JP#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. (IF 56.9) 2023 Apr 7;380(6640):eadd6220. Correspondence author

2.  Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N#, Sun JP#. Structure, function and pharmacology of human itch receptor complexes. Nature. (IF 64.8) 2021 Dec;600(7887):164-169. Correspondence author

3.  Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y#, Yang F#, Li Q#, Sun JP#. Structural basis of amine odorant perception by a mammal olfactory receptor. Nature. (IF 64.8) 2023 Jun;618(7963):193-200. Correspondence author

4.  Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhao FH, Zhou FL, Xi YT, Yin WH, He FD, Zhang DL, Zhu ZL, Jiang Y, Torsten Schöneberg, Ines Liebscher#, Xu H. Eric#, Sun JP#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. (IF 64.8). 2022. 2022 Apr;604(7907):763-770. Correspondence author

5.  Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE#, Zhang Y#, Sun JP#. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature. (IF 64.8) 2021 Jan;589(7843):620-626. Correspondence author (Receive Faculty 1000 recommendation)

6.  Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L#, Kong L#, Sun JP#, Yu X#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature. (IF 64.8)2022 Apr;604(7907):771-778. Correspondence author

7.  Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP#, Xie X#, Yu X#, Zhang Y#. Structural basis of GPBAR activation and bile acid recognition. Nature. (IF 64.8) 2020 Nov;587(7834):499-504. Correspondence author

8.  Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP#, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. (IF 64.5) 2021 Feb 18;184(4):943-956.e18. Correspondence author (Cover article, featured recommendations)

9.  Yan Z, Wang JY, Yang F, Zhu KK, Wang PG, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P,Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H,Yu X #, Gao N#, Sun JP#.Cryo-EM structure of the X-linked acrogigantism-related orphan GPR101-Gs complex enabled identification of ligands with rejuvenating potential. Nat Chem Biol.(IF 14.8) 2023 accept. Correspondence author

10  Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F#, Liu Z#, Sun JP#, Yu X#. Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. Nat Chem Biol.(IF 14.8) 2022 Nov;18(11):1196-1203. Correspondence author

11.   Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. (IF 14.8) Nat Chem Biol 2018 Sep;14(9):876-886. Correspondence author

12.  Cheng J, Yang Z, Ge XY, Gao MX, Meng R, Xu X, Zhang YQ, Li RZ, Lin JY, Tian ZM, Wang J, Ning SL, Xu YF, Yang F, Gu JK, Sun JP#, Yu X#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metab. (IF 29.0) 2022 Feb 1;34(2):240-255. Correspondence author

13.  Wang JL, Dou XD, Cheng j, Gao MX, Xu GF, Ding W, Ding JH, Li y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP#, Jiao N# and Yu X#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab. (IF 20.1) 2023 accept. Correspondence author

14.  Chen Y, Mao C, Gu R, Zhao R, Li W, Ma Z, Jia Y, Yu F, Luo J, Fu Y, Sun JP#, Kong W#. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circ Res.(IF 20.1) 2022 Dec 2;131(12):1037-1054. Correspondence author

15.  An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P#, Zhang P#, Yu X#, Sun JP#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proc Natl Acad Sci USA. (IF 11.1). 2022 Apr 12;119(15):e2117004119. Correspondence author

16.  Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X#, Liu Z#, Yang BX#, Du Y#, Sun JP#. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc Natl Acad Sci U S A.(IF 11.1) 2023 Jul 25;120(30):e2216329120 Correspondence author

17.  Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM#, Lin HC#, Yu X#, Sun JP#. Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. Proc Natl Acad Sci U S A. (IF 11.1) 2021 Nov 9;118(45):e2107363118. Correspondence author

18.  Qu CX, Park JY, Yun MW, He QT, Yang F, Kin K, Han D, Li R, T.M.Iverson, V V.Gurevich , Sun JP#, Chung KY#. Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. Proc Natl Acad Sci U S A. (IF 11.1)2021 Sep 14;118(37):e2026491118. Correspondence author

19.  Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L#, Sun JP#, Yu X#, Zhang Y#, Zhang P#. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc Natl Acad Sci U S A. (IF 11.1) 2022 Jul 19;119(29):e2117054119. Correspondence author

20.  Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun JP#, Kong W#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. (IF 20.396) 2021 Jul;31(7):773-790. Correspondence author

21.  Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. (IF 20.396) 2014 Sep;24(9):1067-90. Correspondence author (Received featured comments on contemporaneous article)

22.  Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J#, Liu Z#, Yang F#, Eric Xu H#, Sun JP#. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun. (IF 16.6) 2023 Aug 17;14(1):5004. Correspondence author

23.  He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang J#, Jin C#, Sun JP#, Yu X#. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun. (IF 13.691). 2021 Apr 22;12(1):2396. Correspondence author

24.  Liu Q, He QT, Lyu X, Yang F, Zhu ZL, Xiao P, Yang Z, Zhang F, Yang ZY, Wang XY, Sun P, Wang QW, Qu CX, Gong Z, Lin JY, Xu Z, Song SL, Huang SM, Guo SC, Han MJ, Zhu KK, Chen X, Kahsai AW, Xiao KH, Kong W, Li FH, Ruan K, Li ZJ, Yu X, Niu XG, Jin CW, Wang J#, Sun JP#. DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. Nat Commun. (IF 13.691) 2020 Sep 25;11(1):4857.Correspondence author (Receive Faculty 1000 recommendation)

25.  Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong W#. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. (IF 13.691) 2018 Jan 2;9(1):11. Correspondence author

26.  Liu CH, Gong Z, Liang Zl, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Xiao KH, Zhou Z, Yu X#, Sun JP#. Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun. (IF 13.691) 2017 Feb 9;8:14335. Correspondence author (Received feature reviews from Channels, Channels (Austin). 2017 May 1:1-3.)

27.  Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR. Nat Commun. (IF 13.691) 2015 Sep 8;6:8202. Correspondence author (Receive Faculty 1000 referrals)

28.  Lu S#, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun JP#, Zhang J#. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nat Commun. (IF 13.691) 2021 Aug 5;12(1):4721. Correspondence author

29.  Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Lin A, Kahsai A, Cahill III T, Chen ZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry. (IF 12.069) 2017 Apr 15;81(8):654-670. Correspondence author (Receive Faculty 1000 Recommendations, cover article)

30.  Qu CX, Mao CY, Xiao P, Shen QY, Zhong YN, Yang F, Shen DD, Tao XN, Zhang HB, Yan X, Zhao RJ, He JY, Guan Y, Zhang C, Hou GH, Zhang PJ, Hou GG, Li ZJ, Yu X, Chai RJ#, Guan YF, Sun JP#, Zhang Y#. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2 (EP2). Science Advances (IF 13.116) 2021 Apr 2;7(14):eabf1268. Correspondence author

31.  Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM#, Sun JP#, Xu ZG#. Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment. Adv Sci (Weinh). (IF 15.1) 2023 Jun;10(16):e2205993. Correspondence author

32.  Lin JY, Cheng J, Du YQ, Pan W, Zhang Z, Wang J, An J, Yang F, Xu YF, Lin H, An WT, Wang J, Yang Z, Chai RJ, Sha XY, Hu H.L#, Sun JP#, Yu X#. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discov. (IF 10.56) 2020 Apr 7;6:20. Correspondence author

33.  Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun JP#, Sun HY#. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials. (IF 12.47) 2017 Sep;140:220-229.Correspondence author

34.  Han MJ, He QT, Yang M, Chen C, Yao Y, Liu X, Wang Y, Zhu ZL, Zhu KK, Qu C, Yang F, Hu C, Guo X, Zhang D, Chen C#, Sun JP#,Wang J#. Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction. Chem Sci. 2021 May 31;12(26):9114-9123. Correspondence author

35.  Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12. Cell Reports (IF 8.816). 2016 May 10;15(6):1345-58. Correspondence author

36.  Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#.Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife. (IF 8.508) 2018 Feb 2;7:e33432. Correspondence author

37.  Xu YF, Chen X, Yang Z, Xiao P, Liu CH, Li KS, Yang XZ, Wang YJ, Zhu ZL, Xu ZG, Zhang S, Wang C, Song YC, Zhao WD, Wang CH, Ji ZL, Zhang ZY, Cui M#, Sun JP#, Yu X#. (2021) PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. EMBO Reports. 2021, vol. 22,5 (2021): e52141. ( IF 8.80 ) Correspondence author

38.  Yang Z, Cheng J, Shang P, Sun JP#, Yu X. Emerging roles of olfactory receptors in glucose metabolism. Trends Cell Biol.(IF 19.0) 2023 Jun;33(6):463-476. Correspondence author

39.  Huang S, Xiao P, Sun JP#. Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduct Target Ther. (IF 13.195) 2020 Jul 21;5(1):127. Correspondence author

40.  Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Cui M, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia. (IF 6.871) .2014 Sep;57(9):1899-910 Correspondence author

41.  Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J. Med Chem. (IF 6.521). 2014 Nov 26;57(22):9309-22. Correspondence author

42.  Huang SM, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP #, Wang J#. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem. 2019 Dec 3;91(23):14936-14942. (IF 6.642) Correspondence author

43.  Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X#. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem. (IF 4.297) 2019 May 24;294(21):8653-8663. Correspondence author

44.  Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A,Wang C, Yu X, Wu JW#, Sun JP#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem. (IF 4.297) 2018 Oct 19;293(42):16226-16241.Correspondence author

45.  Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem. (IF 4.863)2014 Aug 29;289(35):24215-25. Correspondence author

46.  Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY# Structural Mechanism of the Arrestin-3/JNK3 Interaction. Structure. (IF 4.831) 2019 Apr 16. 27(7):1162-1170.e3. Correspondence author

47.  Gong Q, Qin W, Xiao P, Wu X, Li L#, Zhang G, Zhang R, Sun JP#, Yao SQ#, Huang W #. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb). (IF 5.989) 2019 Dec 17;56(1):58-61. Correspondence author (Cover article)

48.  Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#, Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells. Br J Pharmacol. (IF 6.148) 2015 Nov;172(21):5050-67. Correspondence author

49.  Zhang D, Wang Y, Lin H, Sun Y, Wang M, Jia Y, Yu X, Jiang H, Xu W, Sun JP#, Xu Z# Function and therapeutic potential of G protein-coupled receptors in epididymis.Br J Pharmacol. (IF 6.148) 2020 Dec;177(24):5489-5508. Correspondence author

50.  Liu J, Li QX, Wang XJ, Zhang C, Duan YQ, Wang ZY, Zhang Y, Yu X, Li NJ, Sun JP#, Yi F#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy. Cell Death Dis. (IF 6.486). 2016 Apr 7;7(4):e2183. Correspondence author

51.  Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol. (IF 3.904) 2017 Sep;92(3):201-210. Correspondence author (Cover article)

52.  Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. (IF 5.384) .2018 Jan;32(1):73-82. Correspondence author

53.  Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#. The catalytic role of the M2 metal ion in PP2Cα. Sci Rep.(IF 5.597)2015 Feb 24;5:8560. Correspondence author

54.  Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#, Sun JP# The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. IJBCB. (IF 4.595) 2014 Dec;57:84-95. Correspondence author

55.  Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP# Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors. Journal of Neurochemistry. (IF 4.371) 2014 Dec;131(6):699-711. Correspondence author

56.  Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). Journal of Neurochemistry. (IF 4.371) 2014 Jan;128(2):315-329. Correspondence author (Receive Faculty 1000 recommendation)

57.  Dolatabad MR, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Liu HD, Shen YM, Yu X, Sun JP#, Zhang PJ# Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem. (IF 4.371) 2019 Feb;148(4):550-560. Correspondence author

58.  Sun JP#, Zhang D, Wang Y, Lin H, Yu X, Xu Z#. The role of G protein-coupled receptors in cochlear planar cell polarity. Int J Biochem Cell Biol. (IF 4.172) 2016 Aug;77(Pt B):220-5. Correspondence author and First author

59.  Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP#. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem. (IF 3.113) 2015 Dec;10(12):1980-7. Correspondence author

60.  Liu HD, Wang WB, Xu ZG#, Liu CH, He DF, Du LP, Li MY, Yu X#, Sun JP#. FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies. Eur J Pharmacol. (IF 3.266) 2015 Sep 15;763(Pt B):160-8. Correspondence author

61.  Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#, Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Scientific Reports. (IF 4.57) 2013;3:2333. Correspondence author

62.  Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X, Sun JP#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. Future Med Chem. (IF 4.065) 2015 Dec;7(18):2429-37. Correspondence author

63.  Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase. FEBS J. (IF 4.267) 2013 Jun;280(11):2700-11. Correspondence author

64.  Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ#, Fang H#, Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorg Med Chem Lett.(IF 2.427)2016 Oct 1;26(19):4795-8. Correspondence author

65.  Sun JP*#, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci. (IF 2.662)2013 May;50(1):204-14. Correspondence author and First author

66.  Xiao P, Yang L, Zhang C, Wang JY#, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB (IF 0.301) 2012, 39(11): 1050-1060. Correspondence author

67.  Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#. Beta2-Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci. (IF 2.662) 2012 Oct;48(2):456-63. Correspondence author

68.  Zhao S, Guo S, Yang C, Gong Z, Wang YM, Jia YL, Jiang XY, Xu LW, Shi L, Yu X, Sun JP#., Zhang Y#., Chen X#. Cell active and functionally-relevant small-molecule agonists of calcitonin receptor. Bioorg Chem. (IF 5.1) 2020 Mar;96:103596. Correspondence author

69.  Sun Y, Zhang D, Ma ML, Lin H, Song Y, Wang J, Ma C, Yu K, An W, Guo S, He D, Yang Z, Xiao P, Hou G, Yu X#., Sun JP#. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. J Biol Chem. (IF 4.237)2021 Jan;296:100174. Correspondence author

70.  Lin JY, Yang Z, Yang C, Du JX, Yang F, Cheng J, Pan W, Zhang SJ, Yan X, Wang Jia, Wang Jin, Tie L, Yu X#, Chen X#, Sun JP#. An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors. J Biol Chem.(IF 4.237)2021 Oct;297(4):101160.Correspondence author

71.  Pei Y, Wen X, Guo SC, Yang ZS, Zhang R, Xiao P, Sun JP#. Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.Biochem Biophys Res Commun.(IF 3.1)2023 Sep 3;671:327-334. Correspondence author

72.  Lu R, Yan X, Fang G, Zhuang Y, Guo L, Zhang C, Wu X, Xiao P, Cao Y, Yang F, Yu X, Sun JP#, Zhou JY#. A molecular mechanism of UDCA engagement with GPBAR and subsequent G protein interaction revealed by scattered alanine scanning. Biochem Biophys Res Commun. (IF 3.1) 2022 Apr 16;600:14-21 Correspondence author 


First author and Co-autors:


1.  X Yu*, Sun JP*, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A. (IF 11.1)2007 Dec 11;104(50):19767-72. Co-first author

2.  Sun JP*, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem. (IF 4.8) 2003 Apr 4; 278(14): 12406-14. First author

3.  Sun JP*, Luo Y*, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem. (IF 4.8) 2007 Sep 28;282(39):29043-51. Co-first author

4.  Sun JP*, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor. J Biol Chem. (IF 4.8) 2003 Aug 29; 278(35): 33392-9. First author

5.  Kotula JW*, Sun JP*, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth. PLoS One. (IF 3.7) 2014 Apr 15;9(4):e93441. Co-first author

6.  Sun JP*, Wang WQ*, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. (IF 2.9) 2005 Sep 13; 44(36):12009-21. Co-first author

7.  Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen AR, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism At A G Protein-Coupled Receptor (GPCR). J Biol Chem. (IF 4.8) 2014 May 16;289(20):14211-24.

8.  Kahsai AW, Rajagopal S, Sun JP, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols. (IF 14.8) 2014 Jun;9(6):1301-19.

9.  Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A. (IF 11.1). 2017 Mar 7;114(10):2562-2567.

10.  Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. (IF 15.9). 2017 Jun 30;127(7):2631-2646.

11.  Wang K, Zhu D, Yu X, Sun JP, Yao W. Differences in the H2S-induced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats. Toxicology. (IF 4.5) 2013 Oct 4;312C:12-17.

12.  Jiang H, Sun JP, Xu Q, Liu Y, Wei J, Young CY, Yuan H, Lou H. Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis. (IF 9.0) 2013 Aug 8;4:e761.

13.  Li F, Shi P, Li J, Yang F, Wang T, Zhang W, Gao F, Ding W, Li D, Li J, Xiong Y, Sun JP, Gong W#, Tian C#, Wang J#. A Genetically Encoded (19) F NMR Probe for Tyrosine Phosphorylation. Angew Chem Int Ed Engl. (IF 13.6); 2013 Apr 2;52(14):3958-62.

14.  Zhu D, Yu X, Sun JP, Li J, Ma X, Yao W#. H(2)S induces catecholamine secretion in rat adrenal chromaffin cells. Toxicology. (IF 4.1) 2012 Dec 8;302(1):40-3.

15.  Hou X, Li K, Yu X, Sun JP, Fang H#. Protein Flexibility in Docking-based Virtual Screening: Discovery of Novel Lymphoid-specific Tyrosine Phosphatase Inhibitors using Multiple Crystal Structures. J Chem Inf Model. (IF 4.8) 2015 Sep 28;55(9):1973-83.

16.  Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q#, Yu X#. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE. (IF 4.6) 2012;7(8):e43631. Epub 2012 Aug 27

17.  Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X#. Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol. (IF 4.0); 2011 0363-6143 1522-1563

18.  Kahsai AW, Xiao K#, Rajagopal S, Ahn S, Shukla AK, Sun JP, Oas TG, Lefkowitz RJ#. Multiple ligand-specific Conformations of the β2-Adrenergic Receptor, Nature Chemical Biology; (IF 16.1). 2011 Aug 21; 7(10):692-700.

19.  Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, and Zhang ZY#. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem. (IF 5.6) 2011 Sep 2;286(35):30526-34.

20.  Xiao K, Sun JP, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP#, Lefkowitz RJ#. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. USA. (IF 10.6) 2010 Aug 107(34), 15299-15304.

21.  Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica. (IF 1.1) 2010 April, 25: 163-170

22. Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor. Nature Biotechnology. (IF 42.3) 2008 Feb;26(2):189-91.

23.  Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Molecular Pharmacology. (IF 4.9) 2008 May; 73(5): 1333-8.

24.  Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY#. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem. (IF 5.6) 2007 Feb 23;282(8):5413-9.

25.  Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. Proc Natl Acad Sci U S A. (IF 10.6). 2006 Apr 4; 103(14):5326-31.

26.  Wang WQ, Sun JP, Zhang ZY. An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem. (IF 4.3) 2003; 3(7): 739-48.

27.  Liu S, Zhu Z, Sun JP, Zhu Z, Huang Q, Teng M, Niu L. Purification, crystallization and preliminary X-ray crystallographic analysis of agkaggregin, a C-type lectin-like protein from Agkistrodon acutus venom. Acta Crystallogr D Biol Crystallogr. (IF 5.3) 2002 Apr; 58(Pt 4): 675-8.

28.  Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun JP, Wang R, Yi F. β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice. J Mol Med (Berl). (IF 5.1) 2018 Jan;96(1):97-109.

29.  Xiao K, Sun JP. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. Cell Signal. (IF 4.1) 2018 Jan;41:56-64.

30.  Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P,Schmitt E, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Zhang B,Scott KL, Hilsenbeck SG, Sun JP, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer .Nature Medicine. (IF 36.2) 2018 May;24(4):505-51

31.  Fang W, Wang Z, Li Q, Wang X, Zhang Y, Sun Y, Tang W, Ma C, Sun JP, Li N, Yi F. Gpr97 Exacerbates AKI by Mediating Sema3A Signaling.J Am Soc Nephrol. (IF 9.3) 2018 May;29(5):1475-1489.

32.  Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP, Yu X. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis. (IF 6.5)2018 Jun 7;9(6):682.

33.  Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors. J Chem Inf Model. (IF 4.8) 2018 Nov 26;58(11):2331-2342.

34.  Yang J, Yin HS, Cao YJ, Jiang ZA, Li YJ, Song MC, Wang YF, Wang ZH, Yang R, Jiang YF, Sun JP, Liu BY, Wang C. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem. (IF 4.4) 2018;49(2):728-742.

35.  Du H, Zou L, Ren R, Li N, Li J, Wang Y, Sun JP, Yang J, Xiong W, Xu Z. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J. (IF 5.4) 2020 Jan;34(1):1136-1149.

36.  Hou X, Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H. Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase by Targeting Computationally Revealed Cryptic Pockets. Eur J Med Chem. (IF 5.6) 2020 Mar 15;190:112131.

37.  Lu Z, Xiao P, Zhou Y, Li Z, Yu X, Sun JP, Shen Y, Zhao B. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. J Cell Mol Med. (IF 4.5) 2020 Oct 13;24(22):13463-71

38.  Wang J, Zhang J, Lin X, Wang Y, Wu X, Yang F, Gao W, Zhang Y, Sun JP, Jiang C, Xu M. DCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction.J Mol Cell Cardiol. (IF 5.1) 2020 Oct 31;151:3-14.

39.  Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun JP, Zhang C, Yi F. Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.Cell Metab. (IF 24.3) 2020 Dec 1;32(6):1052-1062.

40.  Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun JP, Lv P, Zhang H, Wang C. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Front Cell Neurosci. (IF 5.57) 2021 Jun 16;15:658586.

41.  Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y. S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nat Commun. (IF 15.8) 2021 Jul 22;12(1):4452.

42.  Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun JP, Zhou Y, Cui Q, Fu Y, Kong W. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. (IF 27.47) 2021 Jul 28. 144(15):1244-1261.

43.  Zhang GH, Li DY, Tu CF, Meng LL, Tan YQ, Ji ZL, Cheng J, Lu GX, Lin G, Zhang H, Sun JP, Wang M, Du J#, Xu W#. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Hum Mol Genet. (IF 6.13)2021 Aug 20;ddab234.

44.  Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW#, Zhang Y#. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. (IF 25.92) 2021 Aug 25.

45.  Jia Y, Zhang L, Liu ZY, Mao CF, Ma ZH, Li WQ, Yu F, Wang YB, Huang YQ, Zhang WZ, Zheng JG, Wang X, Xu QB, Zhang J, Feng W, Yun CH, Liu CJ, Sun JP, Fu Y, Cui QH#, Kong W#.Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm.Cell Discov.(IF 33.5) 2022 Mar 1;8(1):21.

46.  Du YQ, Sha XY, Cheng J, Wang J, Lin JY, An WT, Pan W, Zhang LJ, Tao XN, Xu YF, Jia YL, Yang Z, Xiao P, Liu M, Sun JP, Yu X#.Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents.Diabetes.(IF 7.7) 2022 Jul 1;71(7):1454-1471.

47.  Zhao LH#, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun JP, Melcher K, Zhang Y, Yu X#, Xu HE#.Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.Nat Commun.(IF 16.6) 2022 Nov 5;13(1):6670.

48.  Lin X, Chen B, Wu YR, Han YQ, Qi A, Wang JY, Yang Z, Wei XH, Zhao TT, Wu LJ, Xie X, Sun JP, Zheng J#, Zhao SW#, Xu F#.Cryo-EM structures of orphan GPR21 signaling complexes.Nat Commun.(IF 16.6) 2023 Jan 13;14(1):216.

49.  Wang H, Du H, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z#, Lu Q#.Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation.Nat Commun.(IF 16.6) 2023 Mar 24;14(1):1657.

50.  Cai Z, Xie N, Gong Z, Yang Z, Lin F, Li Z, Dai R, Chen Y, Zhang S, Zhu S, Zhou S, Lin J, Yu F, Liu L, Sun JP, Zhou J, Li W, Xiong C, Fu Y, Cong X#, Kong W#. Activin Receptor-Like Kinase 3 Directly Couples Gαq (Guanine Nucleotide-Binding Protein Subunit αq)/ Gαq (Guanine Nucleotide-Binding Protein Subunit α11) to Regulate Vascular Contractility.Hypertension.(8.3) 2023 Jun;80(6):1231-1244.

51.  Zhao L, Liu J, Li K, Zhang C, Chen T, Liu Z, Tang Y, Hu X, Shi A, Shu L, Huang S, Lian S, Zhang M, Li H, Sun JP, Yu X, Zhang Z, Zhang Z, Xu Y. PTPN9 dephosphorylates FGFR2pY656/657 via interaction with ACAP1 and ameliorates pemigatinib effect in cholangiocarcinoma. Hepatology.(IF 13.5) 2023 Jul 27.Online ahead of print.

52.  Jia M, Li L, Chen R, Du J, Qiao Z, Zhou D, Liu M, Wang X, Wu J, Xie Y, Sun Y, Zhang Y, Wang Z, Zhang T, Hu H, Sun JP, Tang W#, Yi F#. Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.Mol Ther.(IF 12.4) 2023 Jul 14:S1525-0016(23)00387-8.

53.  Jin S, Lin C, Wang Y, Wang H, Wen X, Xiao P, Li X, Peng Y, Sun JP, Lu YY#, Wang XH#. Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2. J Med Chem. (IF 7.3)2023 Aug 2. Online ahead of print.

54.  Du YQ, Sha XY, Cheng J, Wang J, Lin JY, An WT, Pan W, Zhang LJ, Tao XN, Xu YF, Jia YL, Yang Z, Xiao P, Liu M, Sun JP, Yu X#. Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents. Diabetes. (IF 7.7) 2022 Jul 1;71(7):1454-1471.

51.Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu, Fan Yang, …JP Sun. Structural basis of amine odorant perception by a mammal olfactory receptor. Narure (IF 64.5) 2023 May 24.

52. Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang,Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You,Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong,Shengxuan Peng, Yuan Liu, ChuanzhengWang, Xin Luo1, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou , Zhongmin Liu, Fan Yang , H. Eric Xu, Jin-Peng Sun. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commu.(IF 16.6) 2023 Aug. 17.

53. Pan Shang,,





孙金鹏


政治面貌,党员

个人简介

孙金鹏,研究员,国家杰出青年基金获得者(药理学,2018年), 新基石项目研究员(2023年)

孙金鹏于1998年获中国科学技术大学生物学和计算机科学双学位,2007年获美国爱因斯坦医学院分子药理学博士学位,之后在杜克大学Robert J Lefkowitz教授(2012年诺贝尔化学奖获得者、GPCR领域奠基人)实验室从事膜受体GPCR的相关研究,2011年2月全职回国,担任教授,博士生导师;2021年担任高等医学研究院常务副院长。

孙金鹏长期聚焦于微环境药理学,系统研究膜受体感知微环境并调控生理功能的机制,开发了针对性的干预策略。解析了GPCR感知痒觉、嗅觉、听觉以及力等微环境变化的多种编码机制,探索了听觉和平衡觉受体。发现了识别类固醇的膜受体亚家族,填补了教科书的空白;开发了系统的配体-受体筛选方法,实现了20多个重要GPCR脱孤,其中发现代谢过程中多个药靶受体的内源性配体,包括胰岛中嗅觉受体OLFR109的胰岛素多肽配体以及GPR120和GPR132的脂肪酸配体等,为代谢性疾病的治疗提供了干预策略。系统揭示了GPCR功能多样性的机制,创新性地提出了GPCR磷酸化编码的“笛子模型”、脯氨酸码头分选理论,发现了受体磷酸化编码过程中重要的时序作用,为GPCR的偏向性药物开发奠定了理论基础。

目前以通讯作者在Nature(7篇),Science (1篇,封面), Cell(2篇,1篇封面),Nature Metabolism(1篇),Cell Metabolism(1篇),Nat Chem Biol(3篇),Cell Research(2篇),PNAS(6篇),Nat Commun(7篇)等SCI收录杂志发表80余篇文章,并在国际和国内学术大会做特邀报告,产生广泛学术影响。曾获新基石研究员项目资助(2023年)、国家杰出青年基金(2018年)、谈家桢生命科学创新奖(2022年)、中华医学科技奖-医学科学技术二等奖(2022年)、第三届全国创新争先奖(2023年)等。目前主持科技部重点研发项目、国家自然科学基金重点项目和面上项目、北京市重点项目等多项基金。

教育经历

1993年-1998年,单位,中国科学技术大学 生命科学院生物学,计算机科学,双学士

1998年-2001年,单位,中国科学技术大学 生命科学院,硕士

2001年-2007年,单位,阿尔伯特.爱因斯坦医学院/Albert Einstein College of Medicine 博士,导师,张仲寅(Zhong-yin, Zhang)

2007年-2011年,单位,杜克大学/Duke University 博士后 导师 Robert j. Lefkowitz; James B. 杜克大学药物及生物化学教授,美国科学院院士,邵逸夫奖获得者2007,美国自然科学奖获得者2008,HHMI,2012诺贝尔奖获得者。

工作经历

2021- 山东大学高等医学研究院 常务副院长

2020--今 山东大学基础医学院,党委委员

2016年12月-今 山东大学基础医学院, 生化与分子生物学系 教授,系主任。博士生导师,齐鲁青年学者

2011年1月-今 生化与分子生物学系 教授,博士生导师,齐鲁青年学者

学术任职

    孙金鹏教授目前担任中国生理与病理学术委员会委员,生理与病理协会青年委员会副主任委员,受体与离子通道专业委员会副主任委员;脂质与脂蛋白委员会委员;中国病理生理学会受体专业委员会委员;中国药理学会肾脏专业委员会常务委员;中国干细胞生理专业委员会委员,中国生化与分子药理学会专业委员会委员,中国听觉与听觉障碍专业委员会委员等。担任教育部长江学者,教育部博士点基金评委;教育部科技奖励评委;博士后基金评委;国家自然科学基金面上,重点,国际合作,杰青,优青一审,二审评委。

 

学术论文审稿人

《Nature》;《Science》; 《Cell》; 《Nature Chemical Biology》;《Nature Structural & Molecular Biology》 ;《Biochemistry》 ;《Journal of Neurochemistry》;《J Biol Chem》;《Cell Research》;《Molecular Pharmacology》;《Biochemical Journal》;《CMLS》。

科研项目:

1. 山东大学“齐鲁青年学者”启动经费,2011-2014年

2. 国家自然基金青年项目: 双特异性磷酸酶Slingshot的催化,调控和抑制剂发展,2012-2014年

3. 国家自然基金项目: CCKAR在胰岛B细胞中的偏向性信号转导及针对CCKAR的功能选择性APTAMER的筛选,2013-2016年

4. 国家自然基金项目: 金属离子依赖性蛋白磷酸酶PPM1K的催化机制、底物特异性和功能研究, 2015-2018年

5. 山东省杰出青年基金:靶向G蛋白偶联受体和磷酸酶的药理学研究,2015-2018

6. 国家自然基金国际(地区)合作与交流项目: CCK1受体(CCKAR) 选择性信号转导的结构基础,2016-2018年

7. 国家自然基金项目: 靶向VLGR1治疗耳聋的药理学研究,2018-2021年

8. 国家杰出青年基金项目:靶向GPCR偏向性信号途径的药理学研究, 2019-2023年

9. 国家重点基础研发项目:人类精子成熟关键分子的作用机制和临床转化研究,2019-2021年

10. 国家自然科学基金集成项目:高血压血管重构过程中关键膜蛋白复合体的动态调控机制及干预,2020-2021年

11. 科技部重点研发项目名称:基于真核基因密码子扩展技术的非天然真核系统的构建及其应用课题名称:应用真核基因密码子扩展技术研究重要药物靶点蛋白 的功能与调控机制 ,2020-2024年

12. 北京市自然科学基金重点项目: 靶向黏附类GPCR及应用纳米材料方法辅助实现体外胰岛组织的再造,2020-2024年

13. 山东省自然科学重大基础项目:GPCR在听觉传导中的功能及作用机制研究,2021-2023年

14. 山东省重点研发计划(重大科技创新工程):急危重症和恶性肿瘤诊治关键技术研发及应用,2021-2024年

15. 国家自然基金重点项目:GPR120跨膜信号转导复合物的功能与结构基础,2022-2026年

16. 山东省重点研发计划(重大科技创新工程):胆管癌预防与诊治的精准医疗集成应用示范体系 ,2022-2024年

17. 国家自然基金重点项目:胃肠道间质瘤治疗的脂肪酸和类固醇膜受体的靶点发现、功能研究及靶向药物的发展,2024-2028年

获奖记录:

2023年第二期新基石研究员

2023年山东省先进工作者

2023年全国创新争先奖

2022年度第十五届谈家桢生命科学创新奖

2022 年中华医学科技奖 - 医学科学技术二等奖

2021年山东省教育系统优秀党员

2020年青春奋斗党员创新团队(孙金鹏科研团队)

2020年山东大学重大科技成果奖(自然科学类)

2021年中共山东大学基础医学院优秀共产党员

2021年中共山东大学优秀共产党员

2022年山东大学优秀教师

2022年山东大学第十四届“我心目中的好导师”

2015年山东高等学校优秀科研成果奖一等奖

2014年中国生物化学与分子生物学会第十一次“青年科学家论坛”一等奖

部分大会口头报告及特邀报告

Sun JP (2004) Structure Basis of Specific Inhibition of Yersinia Protein-tyrosine Phosphatase 2004ASBMB annual Meeting, Boston. (Selected honored student talk)

Sun JP (2011) Dissecting Ligand Specific Severn Trans-membrane Receptor Signaling Complexes 2011 BIT's 3rd International Congress of Antibodies March 23 Track 2-1

孙金鹏 (2011) PEST蛋白质酪氨酸磷酸酶底物特异性的分子基础第十届全国酶学学术讨论会

孙金鹏 (2012) GPCR的工作原理,解读2012年诺贝尔化学奖内蒙古大学

Sun JP (2012) Decoding the HER2 C-terminal tyrosine phosphorylation barcode.  Symposium of receptors, associated to 2012 Nobel Chemistry Prize.

孙金鹏 (2014) G蛋白偶联受体的偏向性信号转导 北京大学化学与生物技术学院(深圳)

孙金鹏 (2014) PEST domain containing phosphatases. 国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议青年科学家论坛(厦门),并获得一等奖

Sun JP  (2014) Regulation of the islet homeostasis by β-adrenergic receptors. Xiamen The 4th Workshop on the Hippo pathway

孙金鹏 2014G 蛋白偶联受体在听觉和胰岛功能中的研究 双清论坛第125期,重大疾病导向的G蛋白偶联受体结构、功能和新配体发现研究 专题报告

孙金鹏 2014): G蛋白偶联受体在胰岛功能中的研究 第五届山东省生物化学与分子生物学大会,专题报告

孙金鹏 2015:G蛋白偶联受体的磷酸化编码介导的信号转导机制 (Phospho-decision mechanism of specific arrestin conformations and functions: The music of the receptor revealed by unnatural amino acid incorporation and 19F-NMR) 泛环渤海生物化学与分子生物学会, 专题报告

孙金鹏 2015: G蛋白偶联受体的磷酸化编码 (Phospho-barcoding of the GPCRs). 第九届全国化学生物学会议, 邀请报告

孙金鹏 2016: Arrestin介导的G蛋白偶联受体的偏向性信号转导-一个笛子模型。中国病理生理学会第十三届受体和信号转导专业委员会学术会议

孙金鹏 2017Arrestin介导的G蛋白偶联受体的偏向性信号转导机制及药理学应用。 第十五届全国生化与分子药理学学术会议

孙金鹏  (2021) : G蛋白偶联受体配体识别和信号转导的多样性。高等医学研究院2021年学术年会

 

Sun JP2017 A new connection between the GPCR and channel through arrestin. 19th International Symposium on Chromaffin Cell Biology

Sun JP2017Biased GPCR signaling in the drug development 首届中国大连受体会议

Sun JP2017)靶向GPCR偏向性途径的肾脏病药物发现 第一届全国肾脏药理学学术会议

Sun JP2017Mechanism of GPCR phospho-coding and its application in new drug discovery 2017 Asian Federation for Pharmaceutical Sciences Conference AFPS2017

Sun JP2017)听觉中G蛋白偶联受体的相关研究 第十五届中国生物物理年会,听觉分会

Sun JP2017Arrestin mediated GPCR biased signaling and its application in new drug discovery The 2nd CNPHARS-ASPET Joint Symposia on Pharmacology第二届中-美药理学双边学术会议

国后作为通讯作者发表的论文

1. Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhao FH, Zhou FL, Xi YT, Yin WH, He FD, Zhang DL, Zhu ZL, Jiang Y, Torsten Schöneberg, Ines Liebscher#, Xu H. Eric#, Sun JP#. Structural basis for the tethered peptide activation of adhesion GPCRs. NatureIF 46.486. 2022. 2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y. 通讯作者

2. Xiao P, Guo SC, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Li SL, Tao XN, Yang ZS, Lu Y, He JY, Wang CX, Zhang L#, Kong LL#, Sun JP#, Yu X#. Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4. NatureIF 46.486. 2022 Apr;604(7907):771-778. doi: 10.1038/s41586-022-04590-8. 通讯作者

3. Cheng J, Yang Z, Ge XY, Gao MX, Meng R, Xu X, Zhang YQ, Li RZ, Lin JY, Tian ZM, Wang J, Ning SL, Xu YF, Yang F, Gu JK, Sun JP#, Yu X#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell MetablismIF 27.28. 2022. 通讯作者(同期preview专题评论)

4.  An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P#, Zhang P#, Yu X#, Sun JP#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proc Natl Acad Sci USA. IF 11.21. 2022 Apr 12;119(15):e2117004119.doi: 10.1073/pnas.2117004119. 通讯作者

5. Yang F, Guo LL, Li Y, Wang GP, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu CX, Xu YF, Xiao P, Zhu ZL, Li ZJ, Zhou JY, Yu X, Gao N#, Sun JP#. Structure, function and pharmacology of human itch receptor complexes. NatureIF 46.486. 2021. 通讯作者

6. Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE#, Zhang Y#, Sun JP#. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. NatureIF 46.486. 2021 Jan;589(7843):620-626. 通讯作者 (获得Faculty 1000推荐)

7. Yang F, Mao C, Guo LL, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP#, Xie X#, Yu X#, Zhang Y#.  Structural basis of GPBAR activation and bile acid recognition. NatureIF 46.486. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. 通讯作者

5. 46.486. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. 通讯作者

8. Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu CX, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu, Yang S, Daniel M. Rosenbaum, Sun JP#, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell(IF 38.620). 2021 Feb; doi: 10.1016/j.cell.2021.01.028. 通讯作者 (封面文章,专题推荐)

9.  Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. (IF 13.99) Nat Chem Biol 2018 Sep;14(9):876-886. 通讯作者

10. Liu CH; Gong Z; Liang Zl; Liu ZX, Yang F, Sun YJ; Ma ML; Wang YJ; Xiao KH; Zhou Z; Yu X; Sun JP#; Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling Nature communications. (IF 13.691)  2017 Feb 9;8:14335. doi: 10.1038/ncomms14335. 通讯作者 (获得Channels杂志的专题评论,Channels (Austin). 2017 May 1:1-3.)    

11. Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Lin A, Kahsai A, Cahill III T,  Chen ZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry. (IF 12.069) 2017 Apr 15;81(8):654-670. 通讯作者(获得Faculty 1000推荐,封面文章)

12. Liu Q, He QT, Lyu X, Yang F, Zhu ZL, Xiao P, Yang Z, Zhang F, Yang ZY, Wang XY, Sun P, Wang QW, Qu CX, Gong Z, Lin JY, Xu Z, Song SL, Huang SM, Guo SC, Han MJ, Zhu KK, Chen X, Kahsai AW, Xiao KH, Kong W, Li FH, Ruan K, Li ZJ, Yu X, Niu XG, Jin CW, Wang J#, Sun JP# DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. Nat Commun. (IF 13.691) 2020 Sep 25;11(1):4857. doi: 10.1038/s41467-020-18433-5. (获得Faculty 1000推荐)

13. Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR. Nature Communications. (IF 13.691) 08 Sep 2015 doi:10.1038/ncomms9202通讯作者 (获得Faculty 1000推荐)

14. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong Wei#. Direct Interaction and Dual Roles of Homocysteine on the Angiotensin II Type 1 Receptor in the Aggravation of Vascular Injury.  Nature CommunicationsIF 13.691. 2018 Jan 2;9(1).

15. He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang JY#, Jin CW#, Sun JP#, Yu X#. Structures of arrestin2 bound to different phospho-barcodes and NMR characterization using DeSipher revealed the mechanism underlying the phospho-interaction-pattern-selective functions of arrestin. Nature Communications (IF 13.691). 2021, Accepted. 通讯作者

16. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun JP#,, Kong W#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res.(IF 20.396)2021 Jan 28. doi: 10.1038/s41422-020-00464-8.

17. Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. (IF 20.396)2014 Sep;24(9):1067-90. 通讯作者  (获得同期文章的专题评论)

18. Qu CX, Mao CY, Xiao P, Shen QY, Zhong YN, Yang F, Shen DD, Tao XN, Zhang HB, Yan X, Zhao RJ, He JY, Guan Y, Zhang C, Hou GH, Zhang PJ, Hou GG, Li ZJ, Yu X, Chai RJ#, Guan YF, Sun JP#, Zhang Y#. Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E2 receptor 2 (EP2). Science Advances (IF 13.116) 2021 Jan 12. doi:   通讯作者

19. Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J#, Zhang J#. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nat Commun. (IF 13.69) 2021 Aug 5;12(1):4721. 通讯作者

20. Qu CX, Park JY, Yun MW, He QT, Yang F, Kin K, Han D, Li R, T.M.Iverson, V V.Gurevich , Sun JP#, Chung KY#. Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. Proc Natl Acad Sci U S A (IF 11.20). 2021 Sep 6 Vol. 118 通讯作者

21. Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM#, Lin HC#, Yu X#, Sun JP#. Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways. Proc Natl Acad Sci U S A (IF 11.20). 2021 Sep 23 通讯作者

22. Lin JY, Cheng J, Du YQ, Pan W, Zhang Z, Wang J, An J, Yang F, Xu YF, Lin H, An WT, Wang J, Yang Z, Chai RJ, Sha XY, Hu H.L#, Sun JP#, Yu X#. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals. Cell Discov. (IF 10.56) 2020 Apr 7;6:20. 通讯作者

23. Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun J#, Sun H#. Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials.  (IF 12.47)2017 Sep;140:220-229.通讯作者

24. Han MJ, He QT, Yang M, Chen C, Yao Y, Liu X, Wang Y, Zhu ZL, Zhu KK, Qu C, Yang F, Hu C, Guo X, Zhang D, Chen C#, Sun JP# Wang J#. Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction.Chem Sci. 2021 May 31;12(26):9114-9123.

25. Huang S, Xiao P, Sun J#. Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduct Target Ther. IF 13.195 2020 Jul 21;5(1):127. 通讯作者

26. Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12. Cell Reports (IF 8.816). 2016 May 10;15(6):1345-58. 通讯作者

27. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#.Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife. (IF 8.508) 2018 Feb 2;7. pii: e33432. doi: 10.7554/eLife.33432.

28. Xu YF*#, Chen X#, Yang Z, Xiao P, Liu CH, Li KS, Yang XZ, Wang YJ, Zhu ZL, Xu ZG, Zhang S, Wang C, Song YC, Zhao WD, Wang CH, Ji ZL, Zhang ZY, Cui M*, Sun JP*, Yu X*. (2021) PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. EMBO Reports. 2021, vol. 22,5 (2021): e52141. ( IF 8.80 ) 通讯作者

29. Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia. (IF 6.871) .2014 Sep;57(9):1899-910. doi: 10.1007/s00125-014-3290-0.通讯作者

30. Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of N

30. Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J. Med Chem. (IF 6.521). 2014 Nov 26;57(22):9309-22 PMID: 25372368. 通讯作者 

31. Huang SM(#), Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP #, Wang J#. A Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem. 2019 Oct 31. doi: 10.1021/acs.analchem.9b03305. (IF 6.642)

32. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X# Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.  J Biol Chem. (IF 4.297)2019 May 24;294(21):8653-8663. 通讯作者

33. Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A, Yu X, Wu JW#, Sun J#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem. (IF 4.297)2018 Oct 19;293(42):16226-16241.通讯作者

34. Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem. (IF 4.863)2014 Aug 29;289(35):24215-25.  通讯作者

35. Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY#Structural Mechanism of the Arrestin-3/JNK3 Interaction. Structure.(IF 4.831) 2019 Apr 16. pii: S0969-2126(19)30124-8. 通讯作者

36. Gong Q*, Qin W*, Xiao P*, Wu X, Li L#, Zhang G, Zhang R, Sun J#, Yao SQ#, Huang W #. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb). (IF 5.989)2019 Nov 6. doi: 10.1039/c9cc07680h. 通讯作者 (封面文章)

37. Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#, Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells.  Br J Pharmacol. (IF 6.148). 2015 Nov;172(21):5050-67. 通讯作者

38. Zhang D, Wang Y, Lin H, Sun Y, Wang M, Jia Y, Yu X, Jiang H, Xu W, Sun J#, Xu Z Function and therapeutic potential of GPCRs in epididymis.Br J Pharmacol. (IF 6.148). 2020 Sep 9. doi: 10.1111/bph.15252通讯作者

39. J Liu, QX Li, XJ Wang, C Zhang, YQ Duan, ZY Wang, Y Zhang, X Yu, NJ Li, JP Sun#F Yi#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy. Cell Death and DiseaseIF 6.486 (2016) Apr 7;7: e2183; doi:10.1038/cddis.2016.89.通讯作者

40. Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol.(IF 3.904) 2017 Feb 28. pii: mol.116.107839. (封面文章)

41. Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. (IF5.394)2018 Jan;32(1):73-82.

42. Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#. The catalytic role of the M2 metal ion in PP2Cα. Sci Rep. IF5.5972015 Feb 24;5:8560. doi: 10.1038/srep08560. 通讯作者

43. Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#, Sun JP# The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. IJBCB. (IF 4.595) 2014, 57 Dec, 84-95.  通讯作者

44. Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP#  Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors. Journal of Neurochemistry.IF 4.371 2014 Dec;131(6):699-711.  通讯作者

45. Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). Journal of Neurochemistry. 2014 Jan;128(2):315-29. (IF 4.371) 通讯作者 (获得Faculty 1000推荐)

46. Rostaminasab Dolatabad M, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Hong-da L, Shen YM, Yu X, Sun JP#,  Zhang PJ# Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem. (IF 4.371)2019 Feb;148(4):550-560.

47. Sun J#, Zhang D, Wang Y, Lin H, Yu X, Xu Z. The Role of G Protein-coupled Receptors in Cochlear Planar Cell Polarity. Int J Biochem Cell Biol.(IF 4.172) 2016 Aug;77(Pt B):220-5. 通讯作者兼第一作者

48. Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP# Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem(IF 3.113) 2015 Dec;10(12):1980-7. 通讯作者

49. Liu HD, Wang WB, Xu ZG, Liu CH, He DF, Du LP, Li MY, Yu X, Sun JP#. G protein-coupled receptor 120A hot target for the development of anti-diabetic therapies.  Eur J Pharmacol. (IF 3.266)2015 Sep 15;763(Pt B):160-8. 通讯作者

50. Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#, Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Scientific Reports. (IF 4.576)2013;3:2333. 通讯作者

51. Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X, Sun J#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics . Future Med Chem. (IF 4.065)2015 Dec;7(18):2429-37. 通讯作者

52. Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. PPM1A functions as an ERK phosphatase. FEBS J. IF 4.2672013 Jun;280(11):2700-11. 通讯作者

53. Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ, Fang H, Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorg Med Chem Lett.IF 2.4272016 Oct 1;26(19):4795-8. 通讯作者

54. Sun JP*#, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci.IF 2.662 2013 May;50(1):204-14. 通讯作者兼第一作者55. Xiao P, Yang L, Zhang C, Wang JY, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB (IF 0.301)2012, 39(11): 1050-1060. 通讯作者

56. Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#.  Beta2- Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci. (IF2.662)2012 Oct;48(2):456-63. 通讯作者

57. Zhao S, Guo S, Yang C, Gong Z, Wang Y, Jia Y, Jiang X, Xu L, Shi L, Yu X, Sun J#., Zhang Y#., Chen X#. Cell active and functionally-relevant small-molecule agonists of calcitonin receptor.Bioorg Chem. 2020 Jan 21;96:103596. doi: 10.1016/j.bioorg.2020.103596.v (IF 4.567) 通讯作者

58. Sun Y, Zhang D, Ma ML, Lin H, Song Y, Wang J, Ma C, Yu K, An W, Guo S, He D, Yang Z, Xiao P, Hou G, Yu X#., Sun JP#. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. J Biol Chem. IF 4.2372020 Dec 10 RA120.014726. 通讯作者


第一作者及共同作者发表文章

1. X Yu*, Sun JP*, Y He, X Guo, S Liu, B Zhou, A Hudmon, ZY Zhang. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.  Proc. Natl. Acad. Sci. USA. (IF 10.6)  2007 Dec, 104, 19767-19772. Comment/ Reviews on this paper:  http://www.f1000biology.com/article/1098405/evaluation共同第一作者

2. Sun JP*, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J Biol Chem. (IF 5.6) 2003 Apr 4; 278(14): 12406-14.   第一作者

3. Sun JP*, Luo Y*, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. J Biol Chem. (IF 5.6) 2007 Sep 28;282(39):29043-51. 第一作者

4. Sun JP*, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor. J Biol Chem. (IF 5.6) 2003 Aug 29; 278(35): 33392-9.第一作者

5. Kotula JW*, Sun J* (Co-first author), Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth. PLoS One. (IF 4.0) 2014 Apr 15;9(4):e93441. 共同第一作者

6. Sun JP*, Wang WQ*, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. (IF 3.4)  2005 Sep 13; 44(36):12009-21. 共同第一作者

7. Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen AR, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism At A G Protein-Coupled Receptor (GPCR). J Biol Chem. (IF 5.6) 2014 May 16;289(20):14211-24. PMID:24668815

8. Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols. (IF 13.6) 2014 Jun;9(6):1301-19.

9. Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A. (IF 10.6). 2017 Mar 7;114(10):2562-2567.

10. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. (IF 14.4).  2017 Jun 30;127(7):2631-2646.

11. Wang K, Zhu D, Yu X, Sun J, Yao W. Differences in the H2S-induced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats. Toxicology. (IF 4.1) 2013 Oct 4;312C:12-17.

12. Jiang H, Sun J, Xu Q, Liu Y, Wei J, Young CY, Yuan H, Lou H. Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis. (IF 6.5) 2013 Aug 8;4:e761.

13. Li F, Shi P, Li J, Yang F, Wang T, Zhang W, Gao F, Ding W, Li D, Li J, Xiong Y, Sun J, Gong W, Tian C, Wang J. A Genetically Encoded (19) F NMR Probe for Tyrosine Phosphorylation. Angew Chem Int Ed Engl. (IF 13.6); 2013 Apr 2;52(14):3958-62.

14. Zhu D, Yu X, Sun J, Li J, Ma X, Yao W.H(2)S induces catecholamine secretion in rat adrenal chromaffin cells. Toxicology. (IF 4.1) 2012 Dec 8;302(1):40-3.

15. Hou X, Li K, Yu X, Sun JP, Fang H. Protein Flexibility in Docking-based Virtual Screening: Discovery of Novel Lymphoid-specific Tyrosine Phosphatase Inhibitors using Multiple Crystal Structures. J Chem Inf Model. (IF 4.8)  2015 Sep 28;55(9):1973-83.

16. Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q, Yu X. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE. (IF 4.6) 2012;7(8):e43631. Epub 2012 Aug 27

17. Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X  Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol. (IF 4.0); 2011 0363-6143 1522-1563

18. Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ Multiple ligand-specific Conformations of the β2-Adrenergic Receptor, Nature Chemical Biology; (IF 16.1). 2011 Aug 21; 7(10):692-700.

19. Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, and Zhang ZY  Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem. (IF 5.6) 2011 Sep 2;286(35):30526-34.

20. Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. USA. (IF 10.6)  2010 Aug 107(34), 15299-15304.

21. Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica. (IF 1.1)  2010 April, 25: 163-170

22. Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor. Nature Biotechnology. (IF 42.3) 2008 Feb;26(2):189-91.

23. Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Molecular Pharmacology. (IF 4.9) 2008 May; 73(5): 1333-8.

24. Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem. (IF 5.6) 2007 Feb 23;282(8):5413-9.

25.  Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.  Proc Natl Acad Sci U S A. (IF 10.6). 2006 Apr 4; 103(14):5326-31.

26. Wang WQ, Sun JP, Zhang ZY. An overview of the protein tyrosine phosphatase superfamily. Curr Top Med Chem. (IF 4.3) 2003; 3(7): 739-48.  

27. Liu S, Zhu Z, Sun J, Zhu Z, Huang Q, Teng M, Niu L. Purification, crystallization and preliminary X-ray crystallographic analysis of agkaggregin, a C-type lectin-like protein from Agkistrodon acutus venom. Acta Crystallogr D Biol Crystallogr. (IF 5.3) 2002 Apr; 58(Pt 4): 675-8.

28. Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F. β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice. J Mol Med (Berl). (IF 5.1) 2018 Jan;96(1):97-109.

29. Xiao K, Sun J. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. Cell Signal. (IF 4.1) 2018 Jan;41:56-64.

30. Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Targeting receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer. Nature Medicine. (IF 36.2) 2018 May;24(4):505-51

31. Fang W, Wang Z, Li Q, Wang X, Zhang Y, Sun Y, Tang W, Ma C, Sun J, Li N, Yi F. Gpr97 Exacerbates AKI by Mediating Sema3A Signaling.J Am Soc Nephrol. (IF 9.3) 2018 May;29(5):1475-1489.

32. Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP, Yu X. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis. (IF 6.5)2018 Jun 7;9(6):682.

33. Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors. J Chem Inf Model. (IF 4.8) 2018 Nov 26;58(11):2331-2342.

34. Yang J, Yin HS, Cao YJ, Jiang ZA, Li YJ, Song MC, Wang YF, Wang ZH, Yang R, Jiang YF, Sun JP, Liu BY, Wang C. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem. (IF 4.4) 2018;49(2):728-742.

35. Du H, Zou L, Ren R, Li N, Li J, Wang Y, Sun J, Yang J, Xiong W, Xu Z. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J. (IF 5.4) 2020 Jan;34(1):1136-1149.

36. Hou X, Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H. Inhibition of Striatal-Enriched Protein Tyrosine Phosphatase by Targeting Computationally Revealed Cryptic Pockets. Eur J Med Chem. (IF 5.6) 2020 Mar 15;190:112131.

37. Lu Z, Xiao P, Zhou Y, Li Z, Yu X, Sun J, Shen Y, Zhao B. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. J Cell Mol Med. (IF 4.5) 2020 Oct 13;24(22):13463-71

38.Wang J, Zhang J, Lin X, Wang Y, Wu X, Yang F, Gao W, Zhang Y, Sun J, Jiang C, Xu M. DCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction.J Mol Cell Cardiol. (IF 5.1) 2020 Oct 31;151:3-14.

39.Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F. Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.Cell Metab. (IF 24.3) 2020 Dec 1;32(6):1052-1062.

40. 李慧,郑文帅,龚正,孙金鹏#. 从医生到杰出科学家: 山东大学学报医学版 2012 12; 50(No.12): 1-9通讯作者

41. 李慧,孙金鹏#. 生命中的两次召唤: 山东大学学报医学版 2012 12; 50(No.12): 10-11通讯作者

42. 孙金鹏#.化学奖-膜受体蛋白的马拉松科学FANS 2012.12 13-14通讯作者

43. 谢迪东,龚正,李容,李慧,刘宏达,孙金鹏#,庞琦#. 磷酸酶STEPQ-loopT541参与催化反应的机制. 山大学报 2013.8通讯作者

44. 杨笃晓,孙金鹏#.现代药靶的核心分子G蛋白偶联受体科学发展报告 2013. 88-96. 通讯作者

45. 肖鹏,孙金鹏,裴钢. G蛋白偶联受体结构分析的近年进展新生物学年鉴.

46.. Yu Y, Yang J, Luan F, Gu G, Zhao R, Wang Q, Dong Z, Tang J, Wang W, Sun J, Lv P, Zhang H, Wang C. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Front Cell Neurosci. (IF 5.57) 2021 Jun 16;15:658586.

47. Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y. S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis. Nat Commun. (IF 15.8) 2021 Jul 22;12(1):4452.

48. Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W.  Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling. Circulation. (IF 27.47) 2021 Jul 28.

49. Zhang G, Li D, Tu C, Meng L, Tan Y, Ji Z, Cheng J, Lu G, Lin G, Zhang H, Sun J, Wang M, Du J, Xu W. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Hum Mol Genet. (IF 6.13)2021 Aug 20;ddab234.

50. Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res. (IF 25.92) 2021 Aug 25.

51.Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu, Fan Yang, …JP Sun. Structural basis of amine odorant perception by a mammal olfactory receptor. Narure (IF 64.5) 2023 May 24.

52. Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang,Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You,Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong,Shengxuan Peng, Yuan Liu, ChuanzhengWang, Xin Luo1, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou , Zhongmin Liu, Fan Yang , H. Eric Xu, Jin-Peng Sun. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commu.(IF 16.6)  2023 Aug. 17.

53. Pan Shang, ,















 

 

 
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