孙金鹏

个人简介

孙金鹏教授，新基石项目研究员（2023年）。先后主持国家杰出青年基金(药理学，2018年) 、国家杰出青年基金延续资助(药理学，2023年)、国家自然科学基金委重点项目等。获第三届全国创新争先奖、谈家桢生命科学创新奖、第十七届中国药学发展奖临床医药研究奖、2023 中国十大科技进展新闻、2023年度中国高等学校十大科技进展等荣誉。

孙金鹏长期从事药理学研究，聚焦于膜受体GPCR，在配-受体识别，药物靶点确证和膜受体药物开发等方面取得系统的原创性成果。孙金鹏建立了内源性配体捕获和高灵敏多通路 GPCR 活力检测等新系统，实现了配-受体瞬时和弱作用的表征，发现了多个重大疾病中主要激素和代谢物的膜受体，如类固醇激素的膜受体，神经酰胺的膜受体，一些其他重要代谢物，胰岛素片段，基质蛋白等的膜受体等。他还开发了微尺度生物力激活等新方法，发现了感知平衡觉和听觉的GPCR受体，阐明了受体介导力和多种感觉，如痒觉，嗅觉，酸碱环境的分子机制，拓宽了 GPCR 配体的识别边界。他有效应用结构生物学联合 AI 辅助的配体设计等新技术，实现高分辨率偏好性 GPCR 配体设计并开发出潜在药用价值的活性物质，超过20个小分子和多肽完成动物水平的药代和毒理研究。

孙金鹏教授以通讯作者（含共）发表Nature（9篇）、Science（2篇，1篇封面）、Cell（5篇，1篇封面）、Cell Metab（2 篇）、Nat Metab（2 篇）、Nat Chem Biol（4 篇）、Mol Cell（2 篇）、Cell Res（3 篇），PNAS（6篇），Nat Commun (10篇)， JBC（5篇）等。 16 篇通讯作者 CNS 文章全为国内工作。SCI 论文 152 篇，其中13篇文章获专题评述，Nature Reviews Drug Discovery进行了3次专题评述，Nature Reviews Cardiology进行了1次专题评述, 5篇文章为高被引，5篇文章被选为文章封面。H 因子 43，引用过百论文 16 篇。成果被编入《药理学》和《疾病学基础与药物干预》 教材。孙金鹏多次受邀在国际/国内学术会议，以及科研院所做学术报告，其中在国际学术会议做主题报告17次，包括2023年在英国格拉斯哥举办的第十九届世界基础与临床药理学大会（19th World Congress of Basic & Clinical Pharmacology）担任Section Chair（Drug development according to signaling diversities of GPCRs）并做主题报告，以及2024年在墨西哥城举办的第十一届国际黏附类受体会议（The 11th International Adhesion GPCR Workshop）作首日特邀主旨报告等。他还参与组织了国际离子通道年会等多次国际会议，在国际药理学领域具有广泛的影响力。

教育经历

1993年－1998年，中国科学技术大学 生命科学院 生物学/计算机科学，双学士

2001年－2007年，阿尔伯特.爱因斯坦医学院/Albert Einstein College of Medicine 博士，分子药理学

2007年－2011年，杜克大学/Duke University，博士后，导师：Robert J Lefkowitz教授（2012年诺贝尔化学奖获得者、GPCR领域奠基人）

孙金鹏于1998年获中国科学技术大学生物学和计算机科学双学位，2007年获美国爱因斯坦医学院分子药理学博士学位，之后在杜克大学Robert J Lefkowitz教授（2012年诺贝尔化学奖获得者、GPCR领域奠基人）实验室从事膜受体GPCR的相关研究，2011年2月全职回国，担任教授，博士生导师；2021年担任高等医学研究院常务副院长，2025年至今担任高等医学研究院院长。

工作经历

2025-今 山东大学高等医学研究院 院长

2021-2025 山东大学高等医学研究院 常务副院长

2020-今 山东大学基础医学院 党委委员

2016年12月-今 山东大学基础医学院， 生化与分子生物学系 教授，系主任。博士生导师，齐鲁青年学者

2011年1月-今 生化与分子生物学系 教授，博士生导师，齐鲁青年学者

学术任职

孙金鹏教授目前担任中国药理学会肾脏专业委员会副主任委员兼秘书长，中国神经科学学会离子通道与受体专业委员会副主任委员，山东药理学会理事长，中国病理生理学会第二届青年委员会副主任委员，中国生物化学与分子生物学脂质与脂蛋白专业委员会常务委员兼秘书长，中国药理学会第十三届心血管药理专业委员会常务委员，中国听觉与听觉障碍专业委员会委员等，山东省生物化学与分子生物学第六届理事会副理事长。

获得奖励及荣誉：

2024年 2023年度中国高等学校十大科技进展

2024年 2023年度两院院士评选十大进展新闻

2023年第二期新基石研究员

2023年全国创新争先奖

2023年山东省先进工作者

2022年度第十五届谈家桢生命科学创新奖

2022年中华医学科技奖-医学科学技术二等奖

2021年山东省教育系统优秀党员

2020年青春奋斗党员创新团队（孙金鹏科研团队）

2020年山东大学重大科技成果奖（自然科学类）

2021年中共山东大学基础医学院优秀共产党员

2021年中共山东大学优秀共产党员

2022年山东大学优秀教师

2022年山东大学第十四届“我心目中的好导师”

2015年山东高等学校优秀科研成果奖一等奖

2014年中国生物化学与分子生物学会第十一次“青年科学家论坛”一等奖

回国后作为通讯作者发表的论文

1. Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu^#, Peng Xiao^#, Fan Yi^#, Ines Liebscher^#, and Jin-Peng Sun^#. Identification, structure, and agonist design of an androgen membrane receptor. Cell. 2025 Mar 20;188(6):1589-1604.e24.

2. Hui Lin, Chuanshun Ma, Kui Cai, Lulu Guo, Xuemei Wang, Lin Lv, Chao Zhang, Jun Lin, Daolai Zhang, Chuan Ye, Tengwei Wang, Shenming Huang, Jifei Han, Zihao Zhang, Junyan Gao, Mingxiang Zhang, Zhao Pu, Fengyang Li, Yongyuan Guo, Xiaojun Zhou, Chengxue Qin, Fan Yi, Xiao Yu^#, Wei Kong^#, Changtao Jiang^#，Jin-Peng Sun^#. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 May;388(6746):eado4188.

3. Siting Zhang, Hui Lin, Jiale Wang, Jingyu Rui, Tengwei Wang, Zeyu Cai, Shenming Huang, Yanxiang Gao, Tianfeng Ma, Rui Fan, Rongbo Dai, Zhiqing Li, Yiting Jia, Qiang Chen, HaoMing He, Jiaai Tan, Shirong Zhu, Rui Gu, Zhigang Dong, Meihong Li, Enmin Xie, Yi Fu, Jingang Zheng^#, Changtao Jiang^#, Jinpeng Sun^# & Wei Kong^#. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis. Nature. 2025 May;641(8062):476-485.

4. Chunyou Mao, Peng Xiao, Xiao-Na Tao, Jiao Qin, Qing-Tao He, Chao Zhang, Sheng-Chao Guo, Ya-Qin Du, Li-Nan Chen, Dan-Dan Shen, Zhi-Shuai Yang, Han-Qiong Zhang, Shen-Ming Huang, Yong-Hao He, Jie Cheng, Ya-Ni Zhong, Pan Shang, Jun Chen, Dao-Lai Zhang, Qian-Lang Wang, Mei-Xia Liu, Guo-Yu Li, Yongyuan Guo, H. Eric Xu, Chuanxin Wang, Cheng Zhang, Shiqing Feng^#, Xiao Yu^#, Yan Zhang^#, Jin-Peng Sun^#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Apr 7;380(6640):eadd6220.

5. Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu^#, Yan Zhang & Jin-Peng Sun^#. Structures of the glucocorticoid-bound adhesion receptor GPR97-G_o complex. Nature. 2021 Jan;589(7843):620-626.

6. Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu^#, Fan Yang^#, Qian Li^# & Jin-Peng Sun^#. Structural basis of amine odorant perception by a mammal olfactory receptor. Nature. 2023 Jun;618(7963):193-200.

7. Fan Yang, Lulu Guo, Yu Li, Guopeng Wang, Jia Wang, Chao Zhang, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao^# & Jin-Peng Sun^#. Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec;600(7887):164-169.

8. Pan Shang, Naikang Rong, Jing-Jing Jiang, Jie Cheng, Ming-Hui Zhang, Dongwei Kang, Lei Qi, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang^#, Qian Li^#, Zhen-Hua Shao^#, Fan Yang^#, and Jin-Peng Sun^#. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24.

9. Xin Wen, Pan Shang, Haidi Chen, Lulu Guo, Naikang Rong, Xiaoyu Jiang, Xuan Li, Junyan Liu, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi^#, Pengju Zhang^#, Fan Yang ^#, Cheng Deng^#, and Jin-Peng Sun^#. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. Cell. 2025 Feb 6;188(3):653-670.e24.

10. Yu-Qi Ping, Peng Xiao, Fan Yang, Ru-Jia Zhao, Sheng-Chao Guo, Xu Yan, Xiang Wu, Chao Zhang, Yan Lu, Fenghui Zhao, Fulai Zhou, Yue-Tong Xi, Wanchao Yin, Feng-Zhen Liu, Dong-Fang He, Dao-Lai Zhang, Zhong-Liang Zhu, Yi Jiang, Lutao Du, Shi-Qing Feng, Torsten Schöneberg, Ines Liebscher^#, H. Eric Xu^# & Jin-Peng Sun^#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770.

11. Peng Xiao, Shengchao Guo, Xin Wen, Qing-Tao He, Hui Lin, Shen-Ming Huang, Lu Gou, Chao Zhang, Zhao Yang, Ya-Ni Zhong, Chuan-Cheng Yang, Yu Li, Zheng Gong, Xiao-Na Tao, Zhi-Shuai Yang, Yan Lu, Shao-Long Li, Jun-Yan He, Chuanxin Wang, Lei Zhang^#, Liangliang Kong^#, Jin-Peng Sun^#, Xiao Yu^#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature. 2022 Apr;604(7907):771-778.

12. Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu^#, Linong Ji^#, Yanli Pang^#, Jin-Peng Sun^#, and Changtao Jiang^#. A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE. Cell. 2025  10.1016/j.cell.2025.05.010.

13. Zheng Xu, Lulu Guo, Jingjing Yu, Siyuan Shen, Chao Wu, Weifeng Zhang, Chang Zhao, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Shengyong Yang, Fan Yang, Xiaohui Wang, Xiao Yu^#, Yunfei Xu^#, Jin-Peng Sun^#, Wei Yan^#, Zhenhua Shao^#. Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature. 2023 Dec;624(7992):672-681.

14. Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C. Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun^#, Xin Xie^#, Xiao Yu^# & Yan Zhang^#. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov;587(7834):499-504.

15. Xiaolong Hu, Weizhen Ao, Mingxin Gao, Lijie Wu, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang^#, Jinpeng Sun^#, Tian Hua^#, Zhi-Jie Liu^#. Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature. 2024 Jul;631(8020):459-466.

16. Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M Rosenbaum, Jin-Peng Sun^#, Yang Du^#, Lei Zhang^#, Xiao Yu^#, Zhenhua Shao^#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 Feb 18;184(4):943-956.e18.

17. Hui Lin, Chuanshun Ma, Xiao Zhuang, Shuo Liu, Dong Liu, Mingxiang Zhang, Yan Lu, Guangjian Zhou, Chao Zhang, Tengwei Wang, Zihao Zhang, Lin Lv, Daolai Zhang, Xiong-Zhong Ruan, Yunfei Xu^#, Renjie Chai^#, Xiao Yu^#, Jin-Peng Sun^# ,Bo Chu^#. Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. Cell Metabolism. 2024 Nov 5;36(11):2402-2418.e10.

18. Jie Cheng, Zhao Yang, Xiao-Yan Ge, Ming-Xin Gao, Ran Meng, Xin Xu, Yu-Qi Zhang, Rui-Zhe Li, Jing-Yu Lin, Zhao-Mei Tian, Jin Wang, Shang-Lei Ning, Yun-Fei Xu, Fan Yang, Jing-Kai Gu, Jin-Peng Sun^#, Xiao Yu^#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metabolism. 2022 Feb 1;34(2):240-255.

19. Ting Zhou, Jie Cheng, Shuo He, Chao Zhang, Ming-Xin Gao, Li-Jun Zhang, Jin-Peng Sun^#, Yi Zhu^#, Ding Ai^#. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. Nature Metabolism. 2024 Aug;6(8):1566-1583.

20. Jia-Le Wang, Xiao-Dong Dou, Jie Cheng, Ming-Xin Gao, Guo-Feng Xu, Wei Ding, Jin-Hui Ding, Yu Li, Si-Han Wang, Zhao-Wei Ji, Xin-Yi Zhao, Tong-Yu Huo, Cai-Fang Zhang, Ya-Meng Liu, Xue-Ying Sha, Jia-Rui Gao, Wen-Hui Zhang, Yong Hao, Cheng Zhang, Jin-Peng Sun^#, Ning Jiao^#, Xiao Yu^#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nature Metabolism. 2023 Oct;5(10):1726-1746.

21. Zhao Yang, Jun-Yan Wang, Fan Yang, Kong-Kai Zhu, Guo-Peng Wang, Ying Guan, Shang-Lei Ning, Yan Lu, Yu Li, Chao Zhang, Yuan Zheng, Shu-Hua Zhou, Xin-Wen Wang, Ming-Wei Wang, Peng Xiao, Fan Yi, Cheng Zhang, Peng-Ju Zhang, Fei Xu, Bao-Hua Liu, Hua Zhang, Xiao Yu^#, Ning Gao^#, Jin-Peng Sun^#. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nature Chemical Biology. 2024 Apr;20(4):484-492.

22. Hui Lin, Peng Xiao, Rui-Qian Bu, Shengchao Guo, Zhao Yang, Daopeng Yuan, Zhong-Liang Zhu, Chuan-Xin Zhang, Qing-Tao He , Chao Zhang, Yu-Qi Ping, Ru-Jia Zhao, Chuan-Shun Ma, Chang-Hao Liu, Xiao-Ning Zhang, Dan Jiang, Shaohui Huang, Yue-Tong Xi, Dao-Lai Zhang, Chen-Yang Xue, Bai-Sheng Yang, Jian-Yuan Li, Hao-Cheng Lin, Xu-Hui Zeng, Han Zhao, Wen-Ming Xu, Fan Yi^#, Zhongmin Liu^#, Jin-Peng Sun ^# and Xiao Yu ^#. Structures of the ADGRG2-G_s complex in apo and ligand-bound forms. Nature Chemical Biology. 2022 Nov;18(11):1196-1203.

23. Fan Yang, Peng Xiao, Chang-xiu Qu, Qi Liu, Liu-yang Wang, Zhi-xin Liu, Qing-tao He, Chuan Liu, Jian-ye Xu, Rui-rui Li, Meng-jing Li, Qing Li, Xu-zhen Guo, Zhao-ya Yang, Dong-fang He, Fan Yi, Ke Ruan, Yue-mao Shen, Xiao Yu, Jin-Peng Sun^# and Jiangyun Wang^#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nature Chemical Biology. 2018 Sep;14(9):876-886.

24. Yuan Zheng, Dan Jiang, Yan Lu, Chao Zhang, Shen-Ming Huang, Haocheng Lin, Daolai Zhang, Shengchao Guo, Jifei Han, Jun Chen, Yaxuan He, Mingxiang Zhang, Yanhui Gao, Yongyuan Guo, Ran Wei, Ming Xia, Yingying Qin, Zhaoqian Liu, Fan Yang, Shaohua Ge, Fan Yi, Xiao Yu^#, Hui Lin^#, Peng Xiao^#, Jin-Peng Sun^# & Shiqing Feng^#. Development of an allosteric adhesion GPCR nanobody with therapeutic potential. Nature Chemical Biology. 2025. https://doi.org/10.1038/ s41589-025-01896-2.

25. Lulu Guo, Kongkai Zhu, Ya-Ni Zhong, Mingxin Gao, Junyan Liu, Zhimin Qi, Zili Liu, Naikang Rong, Minghui Zhang, Dongfang Li, Qiyue Zhang, Gongming Yang, Xinxin Zhang, Mingyue Zhang, Ning Ding, Yu-qi Ping, Zhao Yang, Peng Xiao, Ming Xia^#, Xiao Yu^#, Alatan Gaole^#, Jin-Peng Sun^#, and Fan Yang^#. Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement. Molecular Cell. 2025 Apr 17;85(8):1658-1673.e7.

26. Chunyou Mao, Ru-Jia Zhao, Ying-Jun Dong, Mingxin Gao, Li-Nan Chen, Chao Zhang, Peng Xiao, Jia Guo, Jiao Qin, Dan-Dan Shen, Su-Yu Ji, Shao-Kun Zang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Jin-Peng Sun^#, and Yan Zhang^#. Conformational transitions and activation of the adhesion receptor CD97. Molecular Cell. 2024 Feb 1;84(3):570-583.e7.

27. Zhao Yang, Shu-Hua Zhou, Qi-Yue Zhang, Zhi-Chen Song, Wen-Wen Liu, Yu Sun, Ming-Wei Wang, Xiao-Long Fu, Kong-Kai Zhu, Ying Guan, Jie-Yu Qi, Xiao-Hui Wang, Yu-Nan Sun, Yan Lu, Yu-Qi Ping, Yue-Tong Xi, Zhen-Xiao Teng, Lei Xu, Peng Xiao, Zhi-Gang Xu, Wei Xiong, Wei Qin, Wei Yang^#, Fan Yi^#, Ren-Jie Chai^#, Xiao Yu^#, Jin-Peng Sun^#. A force-sensitive adhesion GPCR is required for equilibrioception. Cell Research. 2025 Apr;35(4):243-264.

28. Yi Fu, Yaqian Huang, Zhao Yang, Yufei Chen, Jingang Zheng, Chenfeng Mao, Zhiqing Li, Zhixin Liu, Bing Yu, Tuoyi Li, Meili Wang, Chanjuan Xu, Yiwei Zhou, Guizhen Zhao, Yiting Jia, Wei Guo, Xin Jia, Tao Zhang, Li Li, Ziyi Liu, Shengchao Guo, Mingliang Ma, Heng Zhang, Bo Liu, Junbao Du, Wengong Wang, Chaoshu Tang, Pei Gao, Qingbo Xu, Xian Wang, Jianfeng Liu, Jinpeng Sun^# and Wei Kong^#. Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Research. 2021 Jul;31(7):773-790.

29. Hong-Mei Wang, Yun-Fei Xu, Shang-Lei Ning, Du-Xiao Yang, Yi Li, Yu-Jie Du, Fan Yang, Ya Zhang, Nan Liang, Wei Yao, Ling-Li Zhang, Li-Chuan Gu, Cheng-Jiang Gao, Qi Pang, Yu-Xin Chen, Kun-Hong Xiao, Rong Ma, Xiao Yu^#, Jin-Peng Sun^#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. 2014 Sep;24(9):1067-90.

30. Yufei Chen, Chenfeng Mao, Rui Gu, Rujia Zhao, Weihao Li, Zihan Ma, Yiting Jia, Fang Yu, Jian Luo, Yi Fu, Jinpeng Sun^#, Wei Kong^#. Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification. Circulation Research. 2022 Dec 2;131(12):1037-1054.

31. Qingqing Chu, Yujia Li, Jichao Wu, Yanjiao Gao, Xiangyun Guo, Jing Li, Hang Lv, Min Liu, Wei Tang, Peng Zhan, Tao Zhang, Huili Hu, Hong Liu, Jinpeng Sun^#, Xiaojie Wang^#, Fan Yi^#. Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension. Circulation Research. 2024 Sep 13;135(7):708-721.

32. Lin-Qi Zhang, Chang-Xiao Che, Ya-Qin Du, Lu-lu Han, Jia-le Wang, Chen-Yu Zhang, Shen-Ming Huang, Zhong-Yuan Zheng, Qing-Tao He, Zhao Yang, Long Zhang, Nan Chen, Fan Yang, Ying-Li Jia, Shi-Min Zhao, De-min Zhou, Chu Wang, Xian Wang, Jin-Peng Sun^#, Lu Tie^#. N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation. Blood. 2025 May 15;145(20):2374-2389.

33. Jun-Hong Dong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, Dong-Fang He, Qiao-Xia Hu, Dao-Lai Zhang, Shang-Lei Ning, Chun-Hua Liu, Chuan Wang, Yue Wang, Xiang-Yao Li, Fan Yi, Amy Lin, Alem W. Kahsai, Thomas Joseph Cahill Ⅲ, Zhe-Yu Chen, Xiao Yu, and Jin-Peng Sun^#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1-regulated lactate metabolism. Biological Psychiatry. 2017 Apr 15;81(8):654-670.

34. Wentao An, Hui Lin, Lijuan Ma, Chao Zhang, Yuan Zheng, Qiuxia Cheng, Chuanshun Ma, Xiang Wu, Zihao Zhang, Yani Zhong, Menghui Wang, Dongfang He, Zhao Yang, Lutao Du, Shiqing Feng, Chuanxin Wang, Fan Yang, Peng Xiao^#, Pengju Zhang^#, Xiao Yu^#, and Jin-Peng Sun^#. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proceedings of the National Academy of Sciences of the United States of America. 2022 Apr 12;119(15):e2117004119.

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