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刘招舰
作者:  来源:  发布时间:2018年11月28日 09:41  浏览次数:

 

 

刘招舰,博士,教授,博士生导师
教育经历:

2005.9-2009.7 山东大学,分子遗传学博士

1995.9 -1999.7 山东农业大学,植物保护专业学士

研究工作经历:

2017.9-至今 山东大学教授

2011.12-2017.8   山东大学副教授

2009.6-2011.11   美国西北大学博士后

2004.9-2009.6    山东大学讲师

2002.7-2004.8    山东大学助教

 

研究兴趣:

1. 非编码RNA在肿瘤发生发展过程中的作用。课题组利用高通量转录组方法分析与肿瘤及干细胞相关的非编码RNA,利用生物信息学并结合功能研究等手段探索非编码RNA的功能和作用机制。

2. RNA异常剪接与肿瘤。选择性剪接(alternative splicing, AS)是指将前体 RNA剪接成多种不同的成熟RNA剪接变异体的过程,是增加基因组多样性的重要机制,剪接调控的紊乱与疾病的发生密切相关。课题组旨在研究核心剪接因子调控选择性剪接的机制及其在肿瘤发生发展中的作用。

 

代表性论文:

1. Wang, Y., X. Zhang, W. Tang, Z. Lin, L. Xu, R. Dong, Y. Li, J. Li, Z. Zhang, X. Li, L. Zhao, J. J. Wei, C. Shao, B. Kong and Z. Liu (2017). "miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-kappaB in high-grade serous ovarian carcinoma." Cell Death Differ 24(12): 2089-2100.(通讯作者)

2. Hou, D., G. Xu, C. Zhang, B. Li, J. Qin, X. Hao, Q. Liu, X. Zhang, J. Liu, J. Wei, Y. Gong, Z. Liu and C. Shao (2017). "Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition." Cell Death Dis 8(10): e3070. (通讯作者)

3. Li, Y., H. Guo, C. Jin, C. Qiu, M. Gao, L. Zhang, Z. Liu and B. Kong (2017). "Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer." Exp Cell Res 357(1): 124-134. (通讯作者)

4. Li, Y., S. Lu, Y. Xu, C. Qiu, C. Jin, Y. Wang, Z. Liu and B. Kong (2017). "Overexpression of CD47 predicts poor prognosis and promotes cancer cell invasion in high-grade serous ovarian carcinoma." Am J Transl Res 9(6): 2901-2910. (通讯作者)

5. Wei, L., X. Liu, W. Zhang, Y. Wei, Y. Li, Q. Zhang, R. Dong, J. S. Kwon, Z. Liu, W. Zheng and B. Kong (2016). "Overexpression and oncogenic function of HMGA2 in endometrial serous carcinogenesis." Am J Cancer Res 6(2): 249-259. (通讯作者)

6. Liu, Z., E. Gersbach, X. Zhang, X. Xu, R. Dong, P. Lee, J. Liu, B. Kong, C. Shao and J. J. Wei (2013). "miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma." Mol Cancer Res 11(11): 1314-1325. (第一作者)

7. Liu, Z., J. Liu, M. F. Segura, C. Shao, P. Lee, Y. Gong, E. Hernando and J. J. Wei (2012). "MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma." J Pathol 228(2): 204-215. (第一作者)

8. Zhang, X., Z. Liu, B. Xu, Z. Sun, Y. Gong and C. Shao (2012). "Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization." Eur J Pharmacol 677(1-3): 47-54. (第一作者)

9. Liu, Z., Q. Liu, B. Xu, J. Wu, C. Guo, F. Zhu, Q. Yang, G. Gao, Y. Gong and C. Shao (2009). "Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage." Mutat Res 662(1-2): 75-83. (第一作者)

 

 

联系方式

济南市文化西路44号教学六楼, 6602
Email:
liujian9782@sdu.edu.cn
电话: 0531-88382046

 

 
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