
齐晓朋,山东大学教授,博士生导师。国家杰出青年科学基金和中国科学院百人计划获得者。主要研究细胞死亡的内在调控, 训练免疫和免疫记忆在脓毒症及肿瘤免疫中的形成机制和干预策略。在相关领域发表SCI论文50余篇,代表性成果发表于Nature Immunology, Immunity, Cell Discovery, Nat Commun, J Clin Invest和J Exp Med等国际学术期刊。现任山东省医学会理事和山东免疫学会常务理事等。研究成果参与获得教育部自然科学一等奖。
研究工作经历:
2020 至今 山东大学高等医学研究院,教授
2016-2020 中科院昆明动物所,中科院“百人计划”A类,研究员
2014-2016 美国圣裘德 (St. Jude) 儿童研究医院, Research Associate
2010-2013 美国国立犹太医学中心 (National Jewish Health), Research Associate
研究方向:
Ø 细胞死亡调控的新机制、新形式以及内在转换调控
Ø 训练免疫的形成机制及其抑制肿瘤发生功能
Ø 免疫记忆以及免疫抑制在后脓毒症中的形成机制
招生类型:
Ø 报考专业-免疫学
Ø 每年招生名额-学术型硕士、博士多名
Ø 实验室长期招聘有科研兴趣的博士后、助理研究员和研究助理等工作人员。联系地址:xqi@email.sdu.edu.cn
代表性论文: (*共同通讯作者)
1. Rudi Mao, Yingqiao Liu, Zhenyu Fan, Yanfeng Li, Luyu Yang, Qingqing Xie, Hongpeng Dong, Mingjun Bi, Chengjiang Gao, Zhe Yang*, Tao Xu*, and Xiaopeng Qi*. 2026. RNA helicase DDX6 governs ASC speck formation in P-bodies and transition to stress granules via phase separation during inflammasome activation. Cell Discovery, in revision.
2. Ziyin Zhang, Nanshu Xiang, Qian Liu, Yanfeng Li, Linhua Wang, Xinpu Yang, Ju Liu, Lichen Zhang, Liaoxun Lu, Yinming Liang, Lu Yang, Xiaopeng Qi* and Chaohong Liu*. 2026. Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytes. Signal Transduction and Targeted Therapy, 11(1):59. doi: 10.1038/s41392-026-02575-x.
3. Rudi Mao, Hongwei Pan, Luyu Yang, Zhenyu Fan, Yanfeng Li, Xinran Yu, Zhen Li, Ying Chen, Yang Yu, Wei Wang, Chengjiang Gao, Jun Peng, Tao Xu*, Yi Zhang* and Xiaopeng Qi*. 2025. Bergeyella cardium variant induces a unique cytoplasmic vacuolization cell death floatptosis in macrophage. Cell Discovery, 11, 83.
4. Yanfeng Li, Qingqing Xie, Luyu Yang, Qian Jiang, Zhiping Liu, Chengjiang Gao, Xiaopeng Qi*, Tao Xu*. 2025. RNF213 regulates blood‒brain barrier integrity by targeting TRAF3 for type I interferon activation during A. baumannii infection. PLoS Pathog, 21(7):e1013333. doi: 10.1371/journal.ppat.1013333.
5. Longjun Li, Tao Xu*, Xiaopeng Qi*. 2024. Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer. Immunological Reviews. doi:10.1111/imr.13417.
6. Luyu Yang, Yanfeng Li, Qingqing Xie, Tao Xu* and Xiaopeng Qi*. 2024. Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection. Cell Communication and Signaling, 22:508.
7. Longjun Li, Rudi Mao, Shenli Yuan, Qingqing Xie, Jinyu Meng, Yu Gu, Siyu Tan, Xiaoqing Xu, Chengjiang Gao, Hongbin Liu, Chunhong Ma, Si Ming Man*, Xiangbo Meng*, Tao Xu* & Xiaopeng Qi*. 2024. NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance. Nat Commun, 15:5170.
8. Xiaomin Guo#, Pengcheng Ma#, Yuwei Li, Yanan Yang, Chaoming Wang, Tao Xu, Huishan Wang, Chaocui Li, Bingyu Mao*, and Xiaopeng Qi*. 2021. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death & Differentiation, 28(2): 640-656.
9. Yu Guo, Rudi Mao, Qingqing Xie, Xiaojie Cheng, Tao Xu, Xiaoyuan Wang, Yan Du*, and Xiaopeng Qi*. 2021. Francisella novicida mutant XWK4 triggers robust inflammasome activation favoring infection. Frontiers in Cell and Developmental Biology (9). DOI:10.3389/fcell.2021.743335.
10. Xiaomin Guo, Chaoming Wang, Tao Xu, Lu Yang, Chaohong Liu, and Xiaopeng Qi. 2021. SiO2 prompts host defense against Acinetobacter baumannii infection by mTORC1 activation. Sci China-Life Sci, 64(6): 982-990.
11. Yu Guo#, Longjun Li#, Tao Xu#, Xiaomin Guo#, Chaoming Wang, Yihui Li, Yanan Yang, Dong Yang, Bin Sun, Xudong Zhao, Genze Shao, and Xiaopeng Qi. 2020. HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Journal of Clinical Investigation, 130(12):6301-6316.
12. Fubing Li#, Yang Li#, Huichun Liang#, Tao Xu#, Yanjie Kong, Maobo Huang, Ji Xiao, Xi Chen, Houjun Xia, Yingying Wu, Zhongmei Zhou, Xiaomin Guo, Chunmiao Hu, Chuanyu Yang, Xu Cheng, Ceshi Chen*, and Xiaopeng Qi*. 2018. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. Journal of Clinical Investigation, 128(9): 4148-4162.
13. Lin Jin#, Xiaomin Guo#, Chuanbin Shen#, Xue Hao#, Peng Sun#, Pengpeng Li, Tao Xu, Chunmiao Hu, Ombati Rose, Hongning Zhou, Mingdong Yang, Cheng-Feng Qin, Jingya Guo, Hua Peng, Mingzhao Zhu, Gong Cheng*, Xiaopeng Qi*, and Ren Lai*. 2018. Salivary factor LTRIN from Aedes aegypti facilitates Zika virus transmission by interfering with the lymphotoxin-b receptor. Nature Immunology, 19: 342-353.
14. Yang Li#, Xiaomin Guo#, Chunmiao Hu, Yan Du, Chuansheng Guo, Di Wang, Weiheng Zhao, Gonghua Huang, Chunliang Li, Qiumin Lu, Ren Lai*, Tao Xu*, and Xiaopeng Qi*. 2018. Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death & Differentiation, 25: 1304–1318.
15. Xiaopeng Qi. 2016. Formation of membrane pores by gasdermin-N causes pyroptosis. Sci China-Life Sci, 07.26, 59(10): 1071-1073.
16. Xiaopeng Qi#, Si Ming Man#, R K Subbarao Malireddi, Rajendra Karki, Christopher Lupfer, Prajwal Gurung, Geoffrey Neale, Clifford Guy, Mohamed Lamkanfi, and Thirumala-Devi Kanneganti. 2016. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. The Journal of Experimental Medicine, 213(10): 2081-97.
17. Rajendra Karki,Si Ming Man, Subbarao Malireddi,Sannula Kesavardhana, Qifan Zhu, Amanda R. Burton,Bhesh Raj Sharma, Xiaopeng Qi, Stephane Pelletier, Peter Vogel, Philip Rosenstiel & Thirumala-Devi Kanneganti. 2016. NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer. Nature, 540: 583–587.
18. Xiaopeng Qi, Prajwal Gurung, R. K. Subbarao Malireddi, Peer W. F. Karmaus, Deepika Sharma, Peter Vogel, Hongbo Chi, Douglas R. Green, and Thirumala-Devi Kanneganti. 2016. Critical role of caspase-8–mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunology, 10(1): 128-138.
19. Xiaopeng Qi, Jessie Hong, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chabon, Brian Graham, Keitaro Ohmori, Yapeng Li, and Hua Huang. 2013. Antagonistic regulation by the transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 39 (1): 97-110.