李东海  研究员

李东海，研究员，博士生导师。毕业于清华大学医学院临床医学专业，心脏外科方向。随后在清华大学机械工程学院高端装备界面科学与技术全国重点实验室开展博士后研究工作，有着丰富的一线临床工作及基础科研经历。主要从事医工交叉相关的研究工作，相关研究成果在PNAS、ACS Nano、ACS AMI、Journal of medicinal chemistry等高水平国际期刊发表SCI检索论文20余篇，申请并授权国家发明专利10余项。

u 研究方向

围绕心血管及神经系统开展相关交叉研究工作，涵盖组织器官再生与系统功能重建、医用材料改性及生物学机制研究、药物功能改性及递送系统研发。

u 教育和工作经历

Ø 2001年9月-2009年7月，南京医科大学，临床医学，本硕连读

Ø 2010年9月-2017年1月，清华大学医学院，临床医学，博士

Ø 2017年3月-2019年12月，清华大学高端装备界面科学与技术全国重点实验室，机械工程，博士后

Ø 2019年12月-至今，山东大学高等医学研究院，研究员

u 近5年代表性论著

1. Jing Zhang, Wenyuan Yu, Guoqiang Li, Guiling Li, Baolan Chen, Luwen Wang*, Yang Yu*, Zhiyuan Liu*, Donghai Li*. Robust and Regular Micronano Binary Texture on the Complex Curved Surface for Enhanced Reendothelialization and Antithrombotic Performance. ACS Nano, 2025 Jan 28;19(3):3676-3693.

2. Shuo Zhang; Qiu Jingru; Hao Zhang; Baolan Chen; Xinke Zhang; Li Donghai*; Li Guiling*; Shan Gang*. Pyrazolo[1,5-a]pyrimidine-Based Type-I Photosensitizer as an Efficient Pyroptosis Inducer for Tumor Ablation. Journal of medicinal chemistry, 2025, 68(10): 10048-10060.

3. Jing Zhang, Kai Ren, Jingru Qiu, Baolan Chen, Weixun Duan, Jincheng Liu*, Guiling Li*, Donghai Li*. Nanotexture and crystal phase regulation for synergistic enhancement in re-endothelialization on medical pure titanium surface. Mater Today Bio.2024 Jan 20:25:100968.

4. Peixia Li, Yayin Du, Jingru Qiu, Qiaoyun Jiang, Weijia Chen, Xinke Zhang, Guiling Li*, Donghai Li*, Gang Shan*. Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy. Journal of medicinal chemistry. 2024 Nov 14;67(21):18930-18942.

5. Guiling Li, Peixia Li, Qiaoyun Jiang, Qianqian Zhang, Jingru Qiu, Donghai Li *, Gang Shan*. Discovery of a Pyridophenoselenazinium-based Photosensitizer with High Photodynamic Efficacy against Breast Cancer Cells. Acta Materia Medica, 2023 March 23.

6. Jing Zhang, Guiling Li, Yifei Qu, Ziyu Guo, Song Zhang*, Donghai Li*. Fabrication and Hemocompatibility Evaluation of a Robust Honeycomb Nanostructure on Medical Pure Titanium Surface. ACS Appl Mater Interfaces. 2022 Feb 23;14(7):9807-9823.(封面论文)

7. Yifei Qu, Ziyu Guo, Jing Zhang, Guiling Li, Song Zhang*, Donghai Li*. Hemodynamic investigation and in vitro evaluation of a novel mixed-flow blood pump. Artif Organs. 2022 Aug;46(8):1533-1543.

8. Jing Zhang^#, Guiling Li^#, Donghai Li^#, Xinrui Zhang, Quhao Li, Zehui Liu, Yujie Fang, Song Zhang, Jia Man. In Vivo Blood-Repellent Performance of a Controllable Facile-Generated Superhydrophobic Surface. ACS Appl Mater Interfaces. 2021 Jun 23;13(24):29021-29033.

9. Jing Zhang, Guiling Li, Jia Man, Yifei Qu, Ziyu Guo, Song Zhang*, Donghai Li*. Mechanism of anti-proteins adsorption behavior on superhydrophobic titanium surface. Surface & Coatings Technology. 2021 June 22.

10. Jing Zhang, Guiling Li, Xinrui Zhang, Zehui Liu, Ziyu Guo, Irfan Ullah, Song Zhang*, Jia Man*, Donghai Li*. Systematically evaluate the physicochemical property and hemocompatibility of phase dependent TiO2 on medical pure titanium. Surface & Coatings Technology. 2020, Volume 404:126501.

11. Donghai Li, Yongjian Li, Guiling Li, Yu Zhang, Jiang Li, Haosheng Chen. Fluorescent Reconstitution on Deposition of PM2.5 in Lung and Extrapulmonary Organs. PNAS (Proceedings of the National Academy of Sciences of the United States of America). 2019, 116(7):2488-2493.

l 联系方式

邮箱：lidonghai@sdu.edu.cn