栗桂玲，山东大学高等医学研究院，副研究员，硕士生导师。毕业于清华大学医学院基础医学专业，随后在清华大学医学院和药学院开展博士后研究工作。目前研究方向是生物医用材料研发及应用，光动力学药物抗肿瘤抗菌的作用及机制研究。近5年相关研究成果发表在PNAS、Journal of medicinal chemistry、Advanced Healthcare Materials、ACS AMI等国际高水平期刊，申请并授权多项发明专利。

u 近5年代表性论著

1. Shuo Zhang; Qiu Jingru; Hao Zhang; Baolan Chen; Xinke Zhang; Li Donghai*; Li Guiling*; Shan Gang*. Pyrazolo[1,5-a]pyrimidine-Based Type-I Photosensitizer as an Efficient Pyroptosis Inducer for Tumor Ablation. Journal of medicinal chemistry, 2025, 68(10): 10048-10060（Top期刊，中科院一区，通讯作者）

2. Chen Weijia^#; Qiu Jingru^#; Li Peixia; Zhang Qianqian; Li Donghai; Li Guiling*; Shan Gang*. Simultaneous Induction of Immunogenic Pyroptosis and PD-L1 Downregulation by One Single Photosensitizer for Synergistic Cancer Photoimmunotherapy. Journal of medicinal chemistry, 2025, 68(3): 3612-3625 （Top期刊，中科院一区，通讯作者）

3. Li Peixia; Du Yayin; Qiu Jingru; Jiang Qiaoyun; Chen Weijia; Zhang Xinke; Li,Guiling*; Li Donghai*; Shan Gang*. Immune Checkpoint-Modulating Photosensitizer That Targets BRD4 for Cancer Photoimmunotherapy. Journal of medicinal chemistry, 2024, 67(21): 18930-18942 （Top期刊，中科院一区，通讯作者）

4. Jing Zhang^#, Kai Ren^#, Jingru Qiu, Baolan Chen, Weixun Duan, Jincheng Liu, Guiling Li*, Donghai Li*. Nanotexture and crystal phase regulation for synergistic enhancement in re-endothelialization on medical pure titanium surface. Materials Today Bio, 2024 Jan 20:25:100968. （Top期刊，中科院一区，通讯作者）

5. Jingru Qiu, Qinghong Liu, Peixia Li, Qiaoyun Jiang, Weijia Chen, Donghai Li, Guiling Li* and Gang Shan*. Ligand-Directed Photodegradation of Interacting Proteins: Oxidative HER2/HER3 Heterodimer Degradation with a Lapatinib-Derived Photosensitizer. Journal of Medicinal Chemistry, 2023, 66(15): 10265-10272. （Top期刊，中科院一区，通讯作者）

6. Qiaoyun Jiang; Peixia Li; Jingru Qiu; Donghai Li; Guiling Li*; Gang Shan*. Lysosome targeting phenalenones as efficient type I/II photosensitizers for anticancer photodynamic therapy. European Journal of Medicinal Chemistry, 2023, 255: 115418（Top期刊，中科院一区，通讯作者）

7. Peixia Li, Jingru Qiu, Yayin Du, Donghai Li, Guiling Li*, Gang Shan*. Nuclear PARP1‐Targeted Photosensitizer as A Dual‐Mode DNA‐Damaging Agent And Immune Activator for Tumor Ablation. Advanced Healthcare Materials, 2023, 12(31): 2301517（Top期刊，通讯作者）

8. Guiling Li^#, Peixia Li^#, Qiaoyun Jiang, Qianqian Zhang, Jingru Qiu, Donghai Li *, Gang Shan* Discovery of a Pyridophenoselenazinium-based Photosensitizer with High Photodynamic Efficacy against Breast Cancer Cells. Acta Materia Medica, 2023 March 23.（新刊，第一作者）

9. Zhongnan Li^#, Guiling Li^#, Yongjian Li, Yuexin Chen, Jiang Li, Haosheng Chen. Flow Field around Bubbles on Formation of Air Embolism in Small Vessels. PNAS. 2021 June 21. 118(26): e2025406118（Top期刊，中科院一区，并列一作）

10. Jing Zhang^#, Guiling Li^#, Xinrui Zhang, Zehui Liu, Ziyu Guo, Irfan Ullah, Song Zhang, Jia Man, Donghai Li. Systematically evaluate the physicochemical property and hemocompatibility of phase dependent TiO2 on medical pure titanium. Surface and Coatings Technology, 2020, Volume 404:126501.（Top期刊，中科院一区，并列一作）

11. Jing Zhang^#, Guiling Li^#, Jia Man, Yifei Qu, Ziyu Guo, Song Zhang, Donghai Li. Mechanism of anti-proteins adsorption behavior on superhydrophobic titanium surface. Surface and Coatings Technology, 2021 June 22.（Top期刊，中科院一区，并列一作）