刘发保 教授 博士生导师，国家级青年人才项目获得者，山东省泰山青年专家，山东大学杰出中青年学者。

主要从事代谢与恶性疾病方面的研究，在相关领域发表论文20余篇，包括以第一作者或并列一作在Nature cell biology (2017), EMBO J (2021), Blood (2021) 等发表多篇论文。

v 工作经历

2021-12-至今 山东大学，高等医学研究院 教授

2014-8至2021-9 威斯康星大学麦迪逊分校 博士后

v 教育经历

2011-9至2014-6， 南开大学， 生物化学与分子生物学， 博士

2008-9至2011-4， 天津科技大学，生物化工，硕士

2004-10至2008-06，济南大学，生物技术，学士

v 研究方向

§ 细胞代谢与肿瘤微环境

v 主持项目

2022年1月 – 2025年12月国家自然科学基金（面上项目）PKM2对乳腺癌细胞脂质代谢的调控作用和机制研究（82173135）

2025年1月– 2028年12月国家自然科学基金（面上项目） CARM1对乳腺癌细胞与微环境脯氨酸代谢的调控作用与机制研究（82472864）

v 发表论文

1. Yin Jilong, Su Zhipeng, Hu Xi, Sun Haojie, Sun Zenghui, Zhou Shuyu, Xu Wenwen, Xi Ying, Liu Lanlan, Zhang Jinwei, Zhao Qian, Qiao Yi, Zhang Jian, Zhang Yingjie, Xu Ying*, Fan Yuchen*, You Xiaona*, Meng Xiangbo* & Liu Fabao*. CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8+ T cell antitumor function. Cell Death and Differentiation (2026). doi: 10.1038/s41418-026-01673-1.

2. Chai Qipeng, Yang Maoshuo, Liu Chunxi, Zhu Xiaolan, Liu Lina, Zhao Wei, Xue Xintong, Zhang Jinwei, Liu Lanlan, Wang Wenjing, Liu Fabao*, You Xiaona* & Zhang Yingjie*. Discovery of a hydroxamic acid-based HDAC11 isoform-selective inhibitor with oral anti-AML potency. Journal of Medicinal Chemistry 69, 6816–6834 (2026). doi: 10.1021/acs.jmedchem.5c03107.

3. You Xiaona, Hu Xi, Sun Zenghui, Xu Wenwen, Liu Lanlan, Huang Tao, Yuan Shenli, Yin Jilong, Wang Hao, Wang Limei, Wang Juncheng, Xu Wei, Zhang Zhiyue*, Zhang Yingjie*, Fan Yuchen* & Liu Fabao*. Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis. Cancer Letters 612, (2025). doi: 10.1016/j.canlet.2025.217493.

4. Yang Maoshuo, Zhao Wei, Zhang Jinwei, Liu Lanlan, Tian Sijia, Miao Yaqing, Jia Yongxin, Wang Limei, Chai Qipeng, Wang Qiang, Liu Fabao*, Zhang Yingjie* & You Xiaona*. HDAC11 inhibition as a potential therapeutic strategy for AML: Target identification, lead discovery, antitumor potency, and mechanism investigation. Journal of Medicinal Chemistry 68, 8124–8142 (2025). doi: 10.1021/acs.jmedchem.4c02550.

5. Zhang Jinwei, Yang Maoshuo, Liu Qian, Xue Xintong, Tian Sijia, Hu Xi, Li Mengzhe, Li Jintao, Chai Qipeng, Liu Fabao*, You Xiaona* & Zhang Yingjie*. Discovery of epigenetic modulators targeting HDACs and EZH2 simultaneously for the treatment of hematological malignancies. Bioorganic Chemistry 153, (2024). doi: 10.1016/j.bioorg.2024.107964.

6. You Xiaona#, Liu Fabao#, Binder Moritz#, Vedder Alexis#, Lasho Terra, Wen Zhi, Gao Xin, Flietner Evan, Rajagopalan Adhithi, Zhou Yun, Finke Christy, Mangaonkar Abhishek, Liao Ruiqi, Kong Guangyao, Ranheim Erik A., Droin Nathalie, Hunter Anthony M., Nikolaev Sergey, Balasis Maria, Abdel-Wahab Omar, Levine Ross L., Will Britta, Nadiminti Kalyan Vara Ganesh, Yang David, Geissler Klaus, Solary Eric, Xu Wei, Padron Eric, Patnaik Mrinal M. & Zhang Jing. Asxl1 loss cooperates with oncogenic nras in mice to reprogram the immune microenvironment and drive leukemic transformation. Blood 139, 1066–1079 (2022). doi: 10.1182/blood.2021012519.

7. Zhang Shengjie#, Liu Fabao#, Halfmann Peter, Behrens Ryan T., Liu Peng, Mcilwain Sean J., Ong Irene M., Donahue Kristine, Wang Yidan, Kawaoka Yoshihiro, Sherer Nathan & Xu Wei. Mediator complex subunit 12 is a gatekeeper of SARS-CoV-2 infection in breast cancer cells. Genes & Diseases 9, 5–8 (2022). doi: 10.1016/j.gendis.2021.08.001.

8. Liu Fabao, Ma Min, Gao Ang, Ma Fengfei, Ma Gui, Liu Peng, Jia Chenxi, Wang Yidan, Donahue Kristine, Zhang Shengjie, Ong Irene M., Keles Sunduz, Li Lingjun & Xu Wei. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. Embo Journal 40, (2021). doi: 10.15252/embj.2021108065.

9. Coriano Carlos G#., Liu Fabao#, Sievers Chelsie K., Liang Muxuan, Wang Yidan, Lim Yoongho, Yu Menggang & Xu Wei. A computational-based approach to identify estrogen receptor α/β heterodimer selective ligands. Molecular Pharmacology 93, 197–207 (2018). doi: 10.1124/mol.117.108696.

10. Liu Fabao, Ma Fengfei, Wang Yuyuan, Hao Ling, Zeng Hao, Jia Chenxi, Wang Yidan, Liu Peng, Ong Irene M., Li Baobin, Chen Guojun, Jiang Jiaoyang, Gong Shaoqin, Li Lingjun & Xu Wei. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis. Nature Cell Biology 19, 1358–1370 (2017). doi: 10.1038/ncb3630.

 v 联系方式

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