王维，博士，教授，博士生导师

山东省优青，山东大学齐鲁青年学者

教育经历：

2007.09-2012.07，中国科学院生物物理研究所，理学博士

2003.09-2007.07，青岛大学医学院，理学学士

工作经历：

2018.12-至今， 山东大学，教授

2014.02-2018.10， 加州大学圣地亚哥分校（UCSD），博士后

2012.08-2013.12， 中国科学院生物物理研究所，研究助理

研究方向：表观转录调控，即研究“与核小体和RNA聚合酶直接相关作用的一类真核转录因子”的结构与功能关系，目前主要研究对象包括Cockayne syndrome B (CSB)，snRNA-activating protein complex (SNAPc)等。

科研项目：

国家自然科学基金面上项目，主持，snRNA转录调控因子SNAPc复合体的结构与功能研究，2022-2025；

国家自然科学基金面上项目，主持，CSB蛋白染色质重塑的机理研究，2020-2023；

山东省自然科学基金优青，主持，表观转录调控，2021-2023。

研究论文：

1) Cao, S. J., Zhang, Y., Jiang, H. Q., Hou, X. B. & Wang, W. (2023) Structural insight into TIPE1 functioning as a lipid transfer protein. J. Biomol. Struct. Dyn.

2) Sun, J.F., Li, X., Hou, X.B., Cao, S.J., Cao, W.J., Zhang, Y., Song, J.Y., Wang, M.F., Wang, H., Yan, X.D., Li, Z.P., Roeder, R.G. & Wang, W. (2022) Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter. Nat. Commun. 13:6871.

3) Oh, J., Shin, J., Unarta, I. C., Wang, W., Feldman, A. W., Karadeema, R. J., Xu, L., Xu, J., Chong, J., Krishnamurthy, R., Huang, X. H., Romesberg, F. E., and Wang, D. (2021) Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. Nat. Chem. Biol. 17, 906-914.

4) Xu, J., Wang, W., Xu, L., Chen, J.Y., Chong, J., Oh, J., Leschziner, A.E., Fu, X.D., and Wang, D. (2020). Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc. Natl. Acad. Sci. U.S.A. 117(41):25486-25493.

5) Wang, W., Xu, J., Limbo, O., Fei, J., Kassavetis, G.A., Chong, J., Kadonaga, J.T., Russell, P., Li, B. & Wang, D. (2019) Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog. Proc. Natl. Acad. Sci. U.S.A. 116(13):6120-6129.

6) Wang, W., Walmacq, C., Chong, J., Kashlev, M. & Wang, D. (2018) Structural Basis of Transcriptional Bypass of Abasic DNA Lesion by RNA Polymerase II. Proc. Natl. Acad. Sci. U.S.A. 115 (11):E2538-E2545.

7) Local, A., Huang, H., Albuquerque, C.P., Singh, N., Lee, A.Y., Wang, W., Wang, C., Hsia, J.E., Shiau, A.K., Ge, K., Corbett, K.D., Wang, D., Zhou, H. & Ren, B. (2018) Identification of H3K4me1-associated proteins at mammalian enhancers. Nat. Genet. 50(1):73-82.

8) Xu, J., Lahiri, I., Wang, W., Wier, A., Cianfrocco, M.A., Chong, J., Hare, A.A., Dervan, P.B., DiMaio, F., Leschziner, A.E. & Wang, D. (2017) Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature 551:653-657.

9) Wang, W., Xu, L., Hu, L., Chong, J., He, C. & Wang, D. (2017) Epigenetic DNA modification N6-methyladenine causes site-specific RNA polymerase II transcriptional pausing. J. Am. Chem. Soc. 139(41):14436-14442.

10) Xu, L., Wang, W., Wu, J., Shin, J.H., Wang, P., Unarta, I.C., Chong, J., Wang, Y. & Wang, D. (2017) Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 114(34):E7082-E7091.

11) Xu, L.^#, Wang, W.^#, Gotte, D., Yang, F., Hare, A.A., Welch, T.R., Li, B.C., Shin, J.H., Chong, J., Strathern, J.N.*, Dervan, P.B. & Wang, D. (2016) RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. Proc. Natl. Acad. Sci. U.S.A. 113(44):12426-12431. (# co-first author)

12) Hwang, C.S., Xu, L., Wang, W., Ulrich, S., Zhang, L., Chong, J., Shin, J.H., Huang, X., Kool, E.T., McKenna, C.E. & Wang, D. (2016) Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Res. 44(8):3820-8.

13) Xu, L., Wang, W., Chong, J., Shin, J.H., Xu, J. & Wang, D. (2015) RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications. Crit. Rev. Biochem. Mol. Biol. 50(6):503-19.

14) Xu, L., Wang, W., Zhang, L., Chong, J., Huang, X. & Wang, D. (2015) Impacts of template backbone heterogeneity on RNA polymerase II transcription. Nucleic Acids Res. 43(4):2232-41.

15) Wang, W., Ding, J.J., Zhang, Y., Hu, Y.L., & Wang, D.C. (2014) Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res. 42(5):3478-3491.

16) Ding, J.J.^#, Wang, W.^#, Feng, H., Zhang, Y.L. & Wang, D.C. (2012) Structural insights into the Pseudomonas aeruginosa Type VI virulence effector Tse1 bacteriolysis and self-protection mechanisms. J. Biol. Chem. 287(32):26911-20. (# co-first author)

联系方式：

济南市经十路17922号山东大学千佛山校区南院10号楼，205室

Email：weiwang007@sdu.edu.cn