李石洋，教授，博士生导师。国家高层次人才引进计划入选者、国家重点研发计划青年项目首席科学家、山东省泰山学者特聘教授、山东省自然科学基金青年A类获得者。相关研究成果以通讯作者发表在Cell Metabolism、Nature Immunology、Nature Metabolism、Nature Communications、Advanced Science等期刊。

研究方向：肠道炎症中的免疫代谢调控机制，寻找靶向代谢治疗肠道及肠外疾病的治疗策略。

联系方式：lishiyang2019(AT)hotmail.com  

教育工作经历

2019.08至今  山东大学 肠道免疫 教授

2018.09-2019.07   佛罗里达大学（美国） 黏膜免疫学 研究助理

2015.12-2018.09   佛罗里达大学（美国） 黏膜免疫学 博后

2013.08-2015.11   西北大学（美国） 黏膜免疫学 博士后

2008.08-2013.06   南开大学 生物化学与分子生物学 博士生（博士）

2004.08-2008.06   南开大学 生物科学 本科生（学士）

论文成果

(*co-first author, #co-corresponding author)

Zheng, M.*, Zhai, Y.*, Yu, Y.*, Shen, J.*, Chu, S., Focaccia, E., Tian, W., Wang, S., Liu, X., Yuan, X., Wang, Y., Li, L., Feng, B., Li, Z., Guo, X., Qiu, J., Zhang, C., Hou, J., Sun, Y., Yang, X., Zuo, X., Heikenwalder, M.^#, Li, Y.^#, Yuan, D.^#, Li, S.^#. (2024) TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response. Cell Metabolism 28:S1550-4131.

Zhao, R.*, Yang, J.*, Zhai, Y., Zhang, H., Zhou, Y., Hong, L., Yuan, D., Xia, R., Liu, Y., Pan, J., Shafi, S., Shi, G., Zhang, R., Luo, D., Yuan, J., Pan, D., Peng, C.^#, Li, S.^#, Sun, M.^#. (2024) Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity. Nature Immunology doi: 10.1038/s41590-024-01921-x.

Wang, S.*, Chen, S.*, Sun, J.*, Han, P., Xu, B., Li, X., Zhong, Y., Xu, Z., Zhang, P., Mi, P., Zhang, C., Li, L., Zhang, H., Xia, Y. ^#, Li, S.^#, Heikenwalder, M.^#, Yuan, D.^#. (2023) m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice. Nature Metabolism 5(5):842–860.

Shen, J.*, Li, Z.*, Liu, X.*, Zheng, M.*, Zhang, P., Chen, Y., Tian, Q., Tian, W., Kou, G., Cui, Y., Xu, B., Zhai, Y., Li, W., Guo, X., Qiu, J., Li, C., He, R., Li, L., Ma, C., Li, Y., Zuo, X.^#, Yuan, D.^#, Li, S.^#. (2024) Sensing of Liver-Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility. Advanced Science 9:e2404274.

Wang, Y.*, Yu, Y.*, Li, L.*, Zheng, M.*, Zhou, J., Gong, H., Feng, B., Wang, X., Meng, X., Cui, Y., Xia, Y., Chu, S., Lin, L., Chang, H., Zhou, R., Ma, M., Li, Z., Ji, R., Lu, M., Yang, X., Zuo, X. ^#, Li, S. ^#, Li, Y.^#. (2023) Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides. Nature Communications 14(1):5093.

Xu, B.*, Zhang, P.*, Tang, X.*, Wang, S., Shen, J., Zheng, Y., Gao, C., Mi, P., Zhang, C., Qu, H.^#, Li, S.^#, Yuan, D.^#. (2022) Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia-Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis. Advanced Science 9(35):e2204697.

Li, S., Bostick, J.W., Qu, J., Zhang, B., Urban, J.F., Avram, D., Zhou, L. (2018) Aryl Hydrocarbon Receptor Signaling Cell-intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity 49(5): 915-928.

Li, S.*, Heller, J.J.*, Bostick, J.W., Lee, A., Schjerven, H., Kastner, P., Zhou, L. (2016) Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor