杨帆，教授，博士生导师，山东大学杰出中青年学者。国家优青（药理学），山东省杰青（药理学）获得者，山东省泰山学者特聘教授，长期聚焦于感知系统中G蛋白偶联受体（GPCR）的药理学研究，揭示了嗅觉，痒觉，酸碱感知及机械力感知的分子机制，并进行了偏好性药物开发，为相关疾病的诊治提供了理论基础，目前以通讯或第一作者在 Nature（4篇），Cell（3篇），Mol Cell，Nat Chem Biol.（2篇)，J Clin Invest , Nat Commun.（3篇）, Cell Discov，Sci. Adv.，PNAS，JMC (2篇) 等杂志发表论文30余篇。目前担任中药成分发掘与利用全国重点实验室副主任，中国药理学会临床药理专业委员会常务委员，中国药理学会生化与肾脏药理专业委员会常务委员，中国医药教育协会中药及民族药研究与评价分会副主任委员。

教育及工作经历

2021/1-至今 山东大学 教授，山东大学杰出中青年学者，齐鲁青年学者

2018/10 -2020/11，山东大学药理学系，特别资助类博士后

2012/9 - 2017/9，山东大学基础医学院生理学系， 博士

2007/9 - 2010/6，中国海洋大学海洋生命学院， 硕士

代表性论著：*:通讯作者 #：第一作者

1. Han X^#, Zhang MH^#, Rong NK^#, Zhu KK^#, Pei Y^#, Ge XY^#, Liu Q, Lu H, Liu J, Zhang LJ, Bao HQ, Pi JH, Fan L, Fu Y, Shao XH, Yan WQ, Gao XH, Zhang MY, Guo LL, Lu Y, Ning SL, Zhang H, Xu YF, Feng XY, Cheng J, Xia M*, Li Q*, Yu X*, Yang F*, Sun JP*. Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors. Cell. 2026 Jan 21:S0092-8674(25)01431-X.

2. Wen X^#, Shang P^#, Chen H^#, Guo L^#, Rong N^#, Jiang X^#, Li X^#, Liu J^#, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F*, Zhang P*, Yang F*, Deng C*, Sun JP*. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. Cell. 2025 Feb 6;188(3):653-670.e24.

3. Guo L^#, Zhu K^#, Zhong YN^#, Gao M^#, Liu J^#, Qi Z^#, Liu Z^#, Rong N, Zhang M, Li D, Zhang Q, Yang G, Zhang X, Zhang M, Ding N, Ping YQ, Yang Z, Xiao P, Xia M*, Yu X*, Gaole A*, Sun JP*, Yang F *. Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement. Mol Cell. 2025 Apr17;85(8):1658-1673.

4. Pan Shang^#, Naikang Rong^#, Jing-Jing Jiang^#, Jie Cheng^#, Ming-Hui Zhang^#, Dong-Wei Kang^#, Lei Qi^#, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Xinyong Liu, Xiao Yu, Yue Wang*, Qian Li*, Zhen-Hua Shao*, Fan Yang*, Jin-Peng Sun*. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.

5. Lulu Guo^#, Jie Cheng^#, Shuo Lian^#, Qun Liu^#, Yan Lu^#, Yuan Zheng^#, Kongkai Zhu^#, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu*, Fan Yang*, Qian Li*, Jin-Peng Sun*. Structural basis of ligand recognition and Golf coupling of the amine olfactory receptor mTAAR9. Nature. 2023 Jun;618(7963):193-200.

6. Jiang K^#, Zeng L^#, Zhang W, He X, Zheng Y, Wang L, Zhang Z, Pu J, Deng C, Yang F*, Zhao S*, Xu F*. Chemosensation of the pheromone spermine by the olfactory TAAR-like receptor TAAR348. Cell Discov. 2025 Sep 27;11(1):79.

7. Lulu Guo^#, Yumu Zhang^#, Guoxing Fang^#, Lu Tie^#, Yuming Zhuang^#, Chenyang Xue^#, Qi Liu^#, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou*, Zhongmin Liu*, Fan Yang*, H. Eric Xu* & Jin-Peng Sun*. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nature communications. Published: 17 August 2023.

8. Fan Yang^#, Lulu Guo^#, Yu Li^#, Guo-Peng Wang^#, Jia Wang^#, Chao Zhang^#, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan，Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao*, Jin-Peng Sun*. Structure, function and pharmacology of human itch receptor complexes. Nature.2021, Dec;600(7887):164-169.

9. Ping YQ^#, Xiao P^#, Fan Yang^#, Zhao RJ^#, Guo SC^#, Yan X^#, Wu X^#, Zhao FH, Zhou FL, Xi YT, Yin WH, He FD, Zhang DL, Zhu ZL, Jiang Y, Torsten Schöneberg, Ines Liebscher*, Xu H. Eric*, Sun JP*. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770.

10.Fan Yang^#, Peng Xiao^#, Chang-xiu Qu^#, Qi Liu^#, Liu-yang Wang, Zhi-xin Liu, Qing-tao He, Chuan Liu, Jian-ye Xu, Rui-rui Li, Meng-jing Li, Qing Li, Xu-zhen Guo, Dong-fang He, Fan Yi, Ka-Young Chuang, Ke Ruan, Yue-mao Shen, Xiao Yu, Jin-peng Sun* & Jiang-yun Wang*. Allosteric mechanisms underlie GPCR signalling to SH3-domain proteins through arrestin. Nat Chem Biol., 2018, 14(9):876-886.

11. Ma L^#, Yang F^#, Wu X^#, Mao C^#, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L*, Sun JP*, Yu X*, Zhang Y*, Zhang P*. Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2117054119.

12. Zhenzhen Zhou^#, Weifeng Zhang, Fabao Zhao, Yanying Sun, Na Wang, Jie Cheng, Peng Zhan, Fan Yang*, Jin-Peng Sun*, Xinyong Liu*, Dongwei Kang*. Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates. J Med Chem. 2024 Mar 14;67(5):4234-4249.

13. Zhenzhen Zhou^#, Weifeng Zhang, Fabao Zhao, Ni Gao, Sining Tao, Na Wang, Jing-Jing Jiang, Fan Yang*, Jin-Peng Sun*, Xinyong Liu*, Dongwei Kang*.In Silico Discovery of Novel Potent Trace Amine-Associated Receptor TAAR1 Agonists as Promising Drug Candidates for the Treatment of Schizophrenia. J Med Chem. 2025 May 22;68(10):10255-10267.

14. Zhao Yang^#, Jun-Yan Wang^#, Fan Yang^#, Kong-Kai Zhu^#, Guo-Peng Wang^#, Ying Guan^#, Shang-Lei Ning^#, Yan Lu, Yu Li, Chao Zhang, Yuan Zheng, Shu-Hua Zhou, Xin-Wen Wang, Ming-Wei Wang, Peng Xiao, Fan Yi, Cheng Zhang, Peng-Ju Zhang, Fei Xu, Bao-Hua Liu, Hua Zhang, Xiao Yu*, Ning Gao*, Jin-Peng Sun*. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat Chem Biol. 2024 Apr;20(4):484-492.

15. Changxiu Qu^#, Chunyou Mao^#, Peng Xiao^#, Qingya Shen^#, Ya-Ni Zhong#，Fan Yang#, Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, Rujia Zhao, Junyan He, Ying Guan, Chao Zhang, Guihua Hou, Peng-Ju Zhang, Zi-Jian Li, Xiao Yu, You-Fei Guan, Jin-Peng Sun*, Yan Zhang*.Ligand recognition, unconventional activation and G protein coupling of the prostaglandin E receptor subtype EP2. Science Advances，2021 Apr 2;7(14):eabf1268.

16. Zhao Yang^#, Fan Yang^#, Daolai Zhang, Zhixin Liu, Amy Lin, Chuan Liu, Peng Xiao, Xiao Yu and Jin-Peng Sun*. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol. 2017, 92(3):201-210. (封面文章)

17. Qing Li^#, Min Cui^#, Fan Yang^#, Na Li, Baichun Jiang, Zhen Yu, Daolai Zhang, Yijing Wang, Xibin Zhu, Huili Hu, Pei-Shan Li, Shang-Lei Ning, Si Wang, Haibo Qi, Hechen Song, Dongfang He, Amy Lin, Jingjing Zhang, Feng Liu, Jiajun Zhao, Ling Gao, Fan Yi, Tian Xue, Jin-Peng Sun, Yaoqin Gong*, and Xiao Yu*. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. The Journal of Clinical Investigation, 2017, 127(7):2631-2646.

主持科研项目：

1 国家自然科学基金优秀青年基金项目，靶向GPCR-Arrestin 信号途径的药理学研究，2021-01 至2023-12。200万，主持。

2 国家自然科学基金创新群体项目，生殖障碍疾病分子机制与干预策略，2024-2029。200万，   骨干。

3 国家重点研发计划, 精子发生障碍的干预新策略,  2022-12至2025-12，393万， 子课题组长。

4 国家自然科学基金委重大集成项目， G蛋白偶联受体的精准动态修饰调控机制和化学干预研究， 2024-1至 2025-12。100万，骨干。

5 山东省杰出青年基金，GPCR偏好性信号转到机制及药物开发,   2024-1至 2026-12。100万，主持。

6  山东省泰山学者特聘教授，靶向感知系统GPCR药理学研究，200万。2025-2030， 主持。

获奖情况

2025.12 钟南山青年科技创新奖

2021.01至2023.12 国家自然科学基金优秀青年基金项目

2024.01至2026.12 山东省杰出青年基金

2023 中国十大科技进展新闻 (骨干)

2023 中华医学奖二等奖(骨干)

联系方式：yangfan@sdu.edu.cn，13573115758