王维， 博士， 教授，博士生导师

教育经历：

2007.09-2012.07，中国科学院生物物理研究所，理学博士

2003.09-2007.07，青岛大学医学院，理学学士

工作经历：

2018.12-至今， 山东大学教授，齐鲁青年学者

2014.02-2018.10， 加州大学圣地亚哥分校，博士后

2012.08-2013.12， 中国科学院生物物理研究所，研究助理

研究方向：

1. 染色质重塑分子（chromatin remodeler）在转录调控过程中的分子机理，以及转录失调造成的一些罕见遗传疾病和肿瘤发生的病理学研究。目前课题组的主要研究对象是一组不属于传统染色质重塑分子的“孤儿蛋白”，比如 Cockayne syndrome B (CSB)，the α-thalassemia retardation X-linked （ATRX）DNA helicase等。

2. 真核RNA聚合酶在表观遗传微环境中的分子机理，尤其是在RNA干扰（RNAi）中起到的特殊作用。

代表性论文：

Wang, W., Xu, J., Chong, J., & Wang, D.* (2018) Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair. DNA Repair (Amst). 71: 43-55

Wang, W., Walmacq, C., Chong, J., Kashlev, M.* & Wang, D.* (2018) Structural Basis of Transcriptional Bypass of Abasic DNA Lesion by RNA Polymerase II. Proc. Natl. Acad. Sci. U.S.A. 115 (11): E2538-E2545.

Local, A., Huang, H., Albuquerque, C.P., Singh, N., Lee, A.Y., Wang, W., Wang, C., Hsia, J.E., Shiau, A.K., Ge, K., Corbett, K.D., Wang, D., Zhou, H. & Ren, B. (2018) Identification of H3K4me1-associated proteins at mammalian enhancers. Nat. Genet. 50(1):73-82.

Xu, J., Lahiri, I., Wang, W., Wier, A., Cianfrocco, M.A., Chong, J., Hare, A.A., Dervan, P.B., DiMaio, F., Leschziner, A.E.* & Wang, D.* (2017) Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. 551:653-657.

Wang, W., Xu, L., Hu, L., Chong, J., He, C. & Wang, D.* (2017) Epigenetic DNA modification N6-methyladenine causes site-specific RNA polymerase II transcriptional pausing. J. Am. Chem. Soc.139(41):14436-14442.

Xu, L., Wang, W., Wu, J., Shin, J.H., Wang, P., Unarta, I.C., Chong, J., Wang, Y.* & Wang, D.* (2017) Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 114(34):E7082-E7091.

Xu, L.#, Wang, W#., Gotte, D., Yang, F., Hare, A.A., Welch, T.R., Li, B.C., Shin, J.H., Chong, J., Strathern, J.N.*, Dervan, P.B.* & Wang, D.* (2016) RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. Proc. Natl. Acad. Sci. U.S.A. 113(44):12426-12431. (co-first author)

Hwang, C.S., Xu, L., Wang, W., Ulrich, S., Zhang, L., Chong, J., Shin, J.H., Huang, X., Kool, E.T., McKenna, C.E.* & Wang, D.* (2016) Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Res. 44(8):3820-8.

Xu, L., Wang, W., Chong, J., Shin, J.H., Xu, J. & Wang, D.* (2015) RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications. Crit. Rev. Biochem. Mol. Biol.50(6):503-19.

Xu, L., Wang, W., Zhang, L., Chong, J., Huang, X. & Wang, D.* (2015) Impacts of template backbone heterogeneity on RNA polymerase II transcription.Nucleic Acids Res. 43(4):2232-41.

Wang W, Ding J, Zhang Y, Hu Y, & Wang DC.* (2014) Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA.Nucleic Acids Res. 42(5):3478-3491.

Ding, J.#, Wang, W.#, Feng, H.2, Zhang, Y.* & Wang, D.C.* (2012) Structural insights into the Pseudomonas aeruginosa Type VI virulence effector Tse1 bacteriolysis and self-protection mechanisms. J Biol Chem 287(32): 26911-20. (co-first author)

Wang, W., Ding, J.J. & Wang, D.C. (2012). Three Dimensional Structure of Pseudomonas aeruginosa Tsi2: a Novel Species-specific Antitoxin-like Protein With Coiled Coil Conformation. Prog Biochem Biophys 39, 640-646.

# These authors contributed equally.

联系方式：

济南市文化西路44号护理楼，201室

Email：weiwang007@sdu.edu.cn