王培会，男，2019年4月全职加入山东大学高等医学研究院，被聘为教授、博士生导师、“齐鲁青年学者”。最新简介请参考http://faculty.sdu.edu.cn/wangpeihui/zh_CN/index/890319/list/index.htm

教育背景

博士（抗病毒免疫）2011/09-2015/09 香港大学 中国香港

硕士（生物学）2008/09-2011/06 中山大学 中国广州

学士（生物技术）2004/09-2008/06 中山大学 中国广州

工作经历

教授、博导、“齐鲁青年学者” 山东大学高等医学研究院 2019/04-

博士后 香港大学李嘉诚医学院 2016/06-2019/02

副研究员 香港大学李嘉诚医学院 2016/01-2016/05

研究助理 香港大学李嘉诚医学院 2015/10-2015/12

研究方向

主要从事病毒与免疫系统相互作用的研究。从两个方面开展：一，抗病毒免疫的激活与调控机制。通过大规模、高通量的筛选技术比如CRISPR-Cas9，发现并鉴定在抗病毒免疫中，尤其是在干扰素(interferon)和炎症小体(inflammasome)通路中，发挥调控作用的蛋白。通过基因过表达、敲除和转基因小鼠、动物疾病模型等，揭示这些蛋白在宿主识别病毒、免疫激活中挥发的作用。二，病毒逃逸宿主免疫建立感染的机制。使用报告基因系统、蛋白质组学等技术，大规模筛选影响宿主抗病毒免疫的病毒蛋白，建立病毒蛋白（如新型冠状病毒）与宿主蛋白的相互作用网络，探明其作用机制以及在病毒感染和复制中的作用。

媒体报道

研究成果被山东电视台、人民日报海外版、央广网、凤凰网、香港文汇网、光明日报、搜狐网、网易、新浪微博、腾讯网、凤凰网、中国教育在线、中华网、齐鲁网、齐鲁壹点等数十家媒体采访和报道。

1）山东新闻联播，视频采访-山东大学科研团队取得新进展 揭示新冠病毒如何实现免疫逃逸( http://sd.iqilu.com/share/video/4870355 )

2）山东电视台《民生实验室》，视频采访-新冠病毒是如何进入我们身体的？( http://sd.iqilu.com/share/video/4771911 )

3）济南广播电视台天下泉城新闻，视频采访-山东大学：传承百年齐鲁医学 汇聚磅礴发展力量 ( https://jntxqc.tianxiaquanchengapp.com/webshare/yw/202447.shtml?share=true )

4）凤凰网-山大团队发现冠状病毒感染诱导其受体ACE2上调( https://ishare.ifeng.com/c/s/7uSW3uDoUzL )

5）人民日报海外版-研究人员：新冠病毒或通过诱导其受体ACE2的表达增强感染传播力( http://m.haiwainet.cn/middle/3541434/2020/0229/content_31730390_1.html )

6）香港文汇网-山东大学联合港大发现冠状病毒感染誘导其受体ACE2上調( http://news.wenweipo.com/2020/02/29/IN2002290025.htm )

7）光明日报-山东大学高等医学研究院无偿提供新型冠状病毒编码基因表达载体( https://overseas.weibo.com/detail/4467560139093209 ; https://new.qq.com/omn/20200202/20200202A0HJK400.html )

8）央广网-研究人员：新冠病毒或通过诱导其受体ACE2的表达增强感染传播力( http://www.cnr.cn/sd/gd/20200229/t20200229_524996973.shtml )

9）大众日报-山东大学团队发现冠状病毒感染诱导其受体ACE2上调( http://dzrb.dzng.com/articleContent/1176_730304.html )

10）光明日报-科技战疫彰显高校担当 ( https://news.gmw.cn/2020-03/25/content_33681654.htm )

获奖、荣誉、学术兼职等

Front Immunol(IF=7.561)副主编（Associate Editor）

Front Pharmacol(IF=5.816)副主编（Associate Editor）

Comp Immunol Microb(IF=2.268)副主编（Associate Editor）

Signal Transduct Target Ther(IF=18.187)、ACS Nano(IF=15.881)、Clin Transl Med(IF=11.492)等期刊审稿人

招生招聘

本实验室实施精英教育，提供国际接轨的科研平台、一流的学术环境和氛围、顶级的实验条件，以及高水平的课题方向。欢迎生命科学、医学、农学等生命科学相关方向博士加盟团队，进行博士后研究(常年有效、2-3名、择优录取)。同时，欢迎有志青年报考硕士和博士研究生，报考前请提前与导师联系，确认当年是否有招生名额。

代表性论著（*通讯作者，#共同第一作者，2021年7月更新）

023.Zhuanchang Wu^#,*, Zhaoying Zhang^#, Xin Wang^#, Jing Zhang^#, Caiyue Ren, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang*, Chunhong Ma*. Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther. 2021 Jun 11;6(1):231. (IF=18.187)

022.Yi Zheng^#, Meng-Wei Zhuang^#, Lulu Han, Jing Zhang, Mei-Ling Nan, Peng Zhan, Dongwei Kang, Xinyong Liu, Chengjiang Gao*, Pei-Hui Wang*. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling. Signal Transduct Target Ther. 2020 Dec 28;5(1):299. (IF=18.187)

021.Jing Zhang^#, Ruth Cruz-Cosme^#, Meng-Wei Zhuang, Dongxiao Liu, Yuan Liu, Shaolei Teng, Pei-Hui Wang*, Qiyi Tang*. A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins. Signal Transduct Target Ther. 2020 Nov 17;5(1):269. (IF=18.187)

020.Pei-Hui Wang, Sin-Yee Fung, Wei-Wei Gao, Jian-Jun Deng, Yun Cheng, Vidyanath Chaudhary, Kit-San Yuen, Ting-Hin Ho, Ching-Ping Chan, Yan Zhang, Kin-Hang Kok, Wanling Yang, Chi-Ping Chan, Dong-Yan Jin*. Identification and characterization of a novel transcript isoform of STING that dominantly inhibits innate immune response. Nucleic Acids Res. 2018 4;46(8):4054-4071. (IF=16.971)

019.Pei-Hui Wang, Zi-Wei Ye, Jian-Jun Deng, Kam-Leung Siu, Wei-Wei Gao, Vidyanath Chaudhary, Yun Cheng, Sin-Yee Fung, Kit-San Yuen, Ting-Hin Ho, Ching-Ping Chan, Yan Zhang, Kin-Hang Kok, Wanling Yang, Chi-Ping Chan, Dong-Yan Jin*. Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. EMBO Rep. 2018 Otc;19(10). (Featured as a cover story, IF=8.807)

018.Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Bo-Du Liu, Xian-De Huang, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. The shrimp IKK-NF-κB signaling pathway regulates antimicrobial peptide expression and may be subverted by white spot syndrome virus (WSSV) to facilitate viral gene expression. Cell Mol Immunol. 10(5):423-36, 2013. (IF=11.53)

其他论著

017.Lulu Han^#, Meng-Wei Zhuang^#, Jian Deng^#, Yi Zheng, Jing Zhang, Mei-Ling Nan, Xue-Jing Zhang, Chengjiang Gao*, Pei-Hui Wang*. SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways. J Med Virol. 2021 Apr 29;10.1002/jmv.27050. (IF=2.327)

016.Meng-Wei Zhuang^#, Yun Cheng^#, Jing Zhang^#, Xue-Mei Jiang, Li Wang, Jian Deng, Pei-Hui Wang*. Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection. J Med Virol. 2020 Nov;92(11):2693-2701. (IF=2.327)

015.Bin Wang^#, Li Wang^#, Xianggen Kong, Jin Geng, Di Xiao, Chunhong Ma, Xue-Mei Jiang, Pei-Hui Wang*. Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients. J Med Virol. 2020 Sep;92(9):1684-1689. (IF=2.327)

014.Pei-Hui Wang* and Jian-Guo He*. Nucleic acid sensing in invertebrates. Int Rev Cel Mol Bio. 2019;345:287-360. (IF=6.813)

013.Jian Deng and Pei-Hui Wang*. Inflammasome Activation and Th17 responses. Mol Immunol 2019 Mar;107:142-164. (IF=4.407)

012.Pei-Hui Wang*, Shao-Ping Weng, Jian-Guo He*. Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective. Dev Comp Immunol 48(2):291-296, 2015. (IF=3.636)

011.Pei-Hui Wang, Tianzhi Huang, Xiaobo Zhang*, Jian-Guo He*. Antiviral defense in shrimp: from innate immunity to antiviral infection. Antiviral Res 108:129-142, 2014. (IF=5.97)

010.Pei-Hui Wang*, Li-Shi Yang, Zhi-Hua Gu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Nucleic acid-induced antiviral immunity in shrimp. Antiviral Res. 99(3):270-80, 2013 (IF=5.97)

009.Pei-Hui Wang*, Ding-Hui Wan, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Characterization of four novel caspases from Litopenaeus vannamei (Lvcaspase2-5) and their role in WSSV infection through dsRNA-mediated gene silencing. PLoS One 8(12):e80418, 2013. (IF=3.24)

008.Pei-Hui Wang*, Ding-Hui Wan, Zhi-Hua Gu, Wei Qiu, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Analysis of expression, cellular localization, and function of three inhibitors of apoptosis (IAPs) from Litopenaeus vannamei during WSSV infection and in regulation of antimicrobial peptide genes (AMPs). PLoS One 8(8): e72592, 2013. (IF=3.24)

007.Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Yong-Gui Chen, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei Toll-interacting protein (LvTollip) is a potential negative regulator of the shrimp Toll pathway involved in the regulation of the shrimp antimicrobial peptide gene penaeidin-4 (PEN4). Dev Comp Immunol. 40(3-4):266-77, 2013. (IF=3.636)

006.Pei-Hui Wang*, Zhi-Hua Gu, Ding-Hui Wan, Wei-Bin Zhu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei Sterile-Alpha and Armadillo Motif Containing Protein (LvSARM) Is Involved in Regulation of Penaeidins and antilipopolysaccharide factors. PLoS One (2):e52088, 2013. (IF=3.24)

005.Pei-Hui Wang*, Jian-Ping Liang, Zhi-Hua Gu, Ding-Hui Wan, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Molecular cloning, characterization and expression analysis of two novel Tolls (LvToll2 and LvToll3) and three putative Spätzle-like Toll ligands (LvSpz1-3) from Litopenaeus vannamei. Dev Comp Immunol. 36(2):359-71, 2012. (IF=3.636)

004.Pei-Hui Wang, Ding-Hui Wan, Li-Ran Pang, Zhi-Hua Gu, Wei Qiu, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Molecular cloning, characterization and expression analysis of the tumor necrosis factor (TNF) superfamily gene, TNF receptor superfamily gene and lipopolysaccharide-induced TNF-α factor (LITAF) gene from Litopenaeus vannamei. Dev Comp Immunol. 36(1):39-50, 2012. (IF=3.636)

003.Pei-Hui Wang, Zhi-Hua Gu, Ding-Hui Wan, Ming-Yan Zhang, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. The shrimp NF-κB pathway is activated by white spot syndrome virus (WSSV) 449 to facilitate the expression of WSSV069 (ie1), WSSV303 and WSSV371. PLoS One 6(9):e24773, 2011. (IF=3.24)

002.Pei-Hui Wang, Ding-Hui Wan, Zhi-Hua Gu, Xie-Xiong Deng, Shao-Ping Weng, Xiao-Qiang Yu, Jian-Guo He*. Litopenaeus vannamei tumor necrosis factor receptor-associated factor 6 (TRAF6) responds to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection and activates antimicrobial peptide genes. Dev Comp Immunol. 35(1):105-14, 2011. (IF=3.636)

001.Pei-Hui Wang^#, Zhi-Hua Gu^#, Xian-De Huang, Bo-Du Liu, Xie-xiong Deng, Hua-Shui Ai, Jing Wang, Zhi-Xin Yin, Shao-Ping Weng, Xiao-Qiang Yu*, Jian-Guo He*. An immune deficiency homolog from the white shrimp, Litopenaeus vannamei, activates antimicrobial peptide genes. Mol Immunol. 46(8-9):1897-904, 2009. (IF=4.407)

联系方式：

山东大学千佛山校区南校园10号楼308

Email：pei-hui.wang(AT)sdu.edu.cn