毕明君 博士 研究员 博士生导师 山东大学“齐鲁青年学者”

长期致力于基因表达调控的表观遗传机制和乳腺癌发生发展的分子机理研究。在Nature Cell Biology、Molecular Cell、Cell Reports等国际著名专业期刊上发表多篇研究性学术论文，参与编写专著1部，目前担任Frontiers in Genetics 和Frontiers in Oncology 杂志审稿编辑。获2013年Monsanto Scholarship Award奖。

教育及工作经历

2022-02-至今，山东大学，高等医学研究院，研究员

2020-06至2022-01，美国德州大学圣安东尼奥健康医学中心，讲师

2016-05至2020-05，美国德州大学圣安东尼奥健康医学中心，博士后

2013-07至2016-05，美国美国辛辛那提大学，医学院，博士后

2008-09至2013-06，中国农业大学，生物学院，博士

研究领域

本课题组以表观遗传学，基因组学和肿瘤生物学为基础，以癌症细胞和小鼠为模型，同时利用生物化学、分子生物学、蛋白质组学（BioID/TurboID）、高通量测序（RNA-seq/ATAC-seq/GRO-seq/ChIP-seq/CUT&RUN/CUT&Tag）、生物信息学和CRISPR基因编辑等多学科前沿技术，采用干湿实验结合的方式，研究人类重大疾病（尤其是乳腺癌耐药性和转移）的表观基因组调控机制以及寻找新的药物治疗靶点。

增强子重编程能够让乳腺癌细胞获得耐药性

近三年发表论文

1. Mingjun Bi*, Zhao Zhang*, Yi-Zhou Jiang, Pengya Xue, Hu Wang, Zhao Lai, Xiaoyong Fu, Carmine De Angelis, Yue Gong, Zhen Gao, Jianhua Ruan, Victor X. Jin, Elisabetta Marangoni, Elodie Montaudon, Christopher K. Glass, Wei Li, Tim Hui-Ming Huang, Zhi-Min Shao, Rachel Schiff, Lizhen Chen, and Zhijie Liu. Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance. Nat. Cell Biol. 2020 22(6):701-715. **Featured as a “News and Views” in Nature Cell Biology: Wu X, Vakoc C. A pliable ERα cistrome evades therapy. Nat. Cell Biol. 2020 Jun; 22(6):619-620.【Selected for Faculty Opinions (F1000Prime) and was rated "Very Good".】

2. Chi Zhu*, Li Li*, Zhao Zhang*, Mingjun Bi*, Hu Wang, Wenyue Su, Karen Hernandez, Pingping Liu, Junqiang Chen, Mingqiu Chen, Tim Hui-Ming Huang, Lizhen Chen, Zhijie Liu. A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer. Mol. Cell 2019 75(4):791-806. **Highlighted with a Commentary article in J. Mol. Cell. Biol.

3. Joo-Hyung Lee, Ruoyu Wang, Feng Xiong, Joanna Krakowiak, Zian Liao, Phuoc T. Nguyen, Elena V. Moroz-Omori, Jiaofang Shao, Xiaoyu Zhu, Michael J. Bolt, Haoli Wu, Pankaj K. Singh, Mingjun Bi, Caleb J. Shi, Naadir Jamal, Guojie Li, Ragini Mistry, Sung Yun Jung, Kuang-Lei Tsai, Josephine C. Ferreron, Fabio Stossi, Amedeo Caflisch, Zhijie Liu, Michael A. Mancini, Wenbo Li. Enhancer RNA m6A methylation facilitates transcription condensates formation and gene activation. Mol. Cell 2021 81(16):3368-3385.

4. Mei Yang, Ji-Hoon Lee, Zhao Zhang, Richard De La Rosa, Mingjun Bi, Yuliang Tan, Yiji Liao, Juyeong Hong, Baowen Du, Yanming Wu, Jessica Scheirer, Tao Hong, Wei Li, Teng Fei, Chen-Lin Hsieh, Zhijie Liu, Wenbo Li, Michael G. Rosenfeld, and Kexin Xu. Enhancer RNAs mediate estrogen-induced decommissioning of selective enhancers by recruiting ERα and its cofactor. Cell Rep. 2020 Jun 23; 31(12):107803.

5. Zhao Zhang, Wei Yu, Dan Tang, Yufan Zhou, Mingjun Bi, Hu Wang, Yan Zheng, Mingqiu Chen, Li Li, Xinping Xu, Wei Zhang, Huimin Tao, Victor X. Jin, Zhijie Liu, and Lizhen Chen. Epigenomics-based identification of estrogen-regulated long noncoding RNAs in ER+ breast cancer. RNA Biol. 2020 Nov; 17(11):1590-1602.

团队建设

真诚欢迎以探索为乐的有志青年能够加入团队，攻读硕士、博士学位；同时欢迎对本实验室研究方向感兴趣的本科生前来进行科研训练。

联系方式

山东大学千佛山校区10号楼217室

mingjunbi@sdu.edu.cn