刘发保 教授 博士生导师，国家级青年人才项目获得者，山东省泰山青年专家，山东大学杰出中青年学者。

主要从事代谢与恶性疾病方面的研究，在相关领域发表论文20余篇，包括以第一作者或并列一作在Nature cell biology (2017), EMBO J (2021), Blood (2021) 等发表多篇论文。

v 工作经历

2021-12-至今 山东大学，高等医学研究院 教授

2014-8至2021-9 威斯康星大学麦迪逊分校 博士后

v 教育经历

2011-9至2014-6， 南开大学， 生物化学与分子生物学， 博士

2008-9至2011-4， 天津科技大学，生物化工，硕士

2004-10至2008-06，济南大学，生物技术，学士

v 研究方向

§ 细胞代谢与机体糖脂稳态

§ 蛋白质精氨酸修饰与肠道内稳态

§ 脂代谢与实体瘤/白血病耐药性

v 招生与招聘

§ 细胞生物学和分子生物学

§ 实验室长期招聘有科研兴趣的博士后和研究助理等工作人员

v 主持项目

§ 国家自然科学基金面上项目， 2022.01-2025.12

v 发表论文

2021

1. Fabao Liu, Min Ma, Ang Gao, Fengfei Ma, Gui Ma, Peng Liu, Chenxi Jia, Yidan Wang, Kristine Donahue, Shengjie Zhang, Irene M, Ong, Sunduz Keles, Lingjun Li, Wei Xu. (2021) PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. EMBO J 15;40(22):e108065.

2. Xiaona You#, Fabao Liu#, Moritz Binder#, Alexis Vedder#, Terra L Lasho, Zhi Wen, MD & PhD, Xin GAO, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy M. Finke, Abhishek A Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie M Droin, Anthony M. Hunter, Sergey Nikolaev, Maria E. Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David T Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M Patnaik, Jing Zhang. (2021) Asxl1loss cooperates with oncogenic Nras in mice to reprogram immune microenvironment and drive leukemic transformation. Blood (doi: 10.1182)

3. Shengjie Zhang#, Fabao Liu#, Peter Halfmann, Ryan T. Behrens, Peng Liu, Irene M. Ong, Kristine Donahue, Yidan Wang, Yoshihiro Kawaoka, Nathan Sherer, Wei Xu. (2021) Mediator complex subunit 12 is a gatekeeper of SARS-CoV-2 infection in triple-negative breast cancer cells. Genes & diseases 2021 Aug 17.  doi: 10.1016

2018

4. Carlos Coriano#, Fabao Liu#, Chelsie Sievers, Muxuan Liang, Yidan Wang, Yoongho Lim, Menggang Yu, Wei Xu. (2018) A computational based approach to identify estrogen receptor alpha/beta heterodimer selective ligands. Molecular pharmacology, vol. 117:108696

2017

5. Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng, Chenxi Jia, Yidan Wang, Peng Liu, Irene M Ong, Baobin Li, Guojun Chen, Jiaoyang Jiang, Shaoqin Gong, Lingjun Li, Wei Xu (2017) PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis. Nature cell biology 19 (11), 1358-1370.

2015

6. Fabao Liu, Xiaona You, Yue Wang, Qian Liu, Yunxia Liu, Shuqin Zhang, Lingyi Chen, Xiaodong Zhang*, Lihong Ye*. (2015)The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis, 35 (5), 1144-1153.

7. Fabao Liu, Weiying Zhang, Xiaona You, Yunxia Liu, Yinghui Li, Zhen Wang, Yue Wang, Xiaodong Zhang*, Lihong Ye*. (2015) The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget, 6 (29), 27199.  

2014

8. Fabao Liu, Xiaona You, Xiumei Chi, Tao Wang, Lihong Ye, Junqi Niu, Xiaodong Zhang*. (2014) Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Biochemical and biophysical research communications, 444 (2), 128-134.

2013-

9. Xiaona You#, Fabao Liu#, Tao Zhang, Yinghui Li, Lihong Ye*, Xiaodong Zhang*.(2013) Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis, 34 (7), 1644-1652.

10. Qiang Gao#, Fabao Liu#, Tongcun Zhang, Jian Zhang, Shiru Jia, Changyan Yu, Kunyu Jiang, Nianfa Gao. (2010) The role of lactic acid adsorption by ion exchange chromatography. Plos One 5(11): e13948

v 联系方式

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