王路雯，山东大学“齐鲁青年学者”。2022年加入山东大学高等医学研究院。

【教育及工作经历】

2022年9月-今，山东大学高等医学研究院 教授

2022年1月-2022年8月， 美国内布拉斯加大学医学中心 (University of Nebraska Medical Center) 讲师

2020年11月-2021年12月， 美国内布拉斯加大学医学中心 (University of Nebraska Medical Center) 博士后

2015年11月-2020年10月，美国凯斯西储大学 (Case Western Reserve University) 博士后

2007年9月-2012年6月，复旦大学 博士

2002年9月-2006年6月，中国农业大学 学士

【研究领域】

本人主要研究方向是细胞线粒体在神经退行性疾病中的功能与作用。神经退行性疾病形成机制十分复杂，受到基因突变、细胞器病变、环境诱导等多种因素影响，至今人们仍无法获知其全貌。近年来针对神经退行性疾病患者的病理研究表明：线粒体异常现象在肌萎缩侧索硬化（amyotrophic lateral sclerosis, ALS）、阿兹海默氏症（Alzheime’s disease, AD）、帕金森氏症（Parkinson's disease, PD）等各种神经退行性疾病中普遍存在。目前，有关线粒体参与神经退行性疾病致病过程的分子机制研究备受关注。本实验室以一系列线粒体形态功能异常小鼠为研究模型，重点关注神经退行性疾病中的线粒体动力与转运、线粒体稳态与蛋白异常沉积、线粒体毒性与治疗型多肽开发，致力于丰富疾病研究领域的理论基础，及研发更有效的神经退行性疾病治疗药物。

【文章发表情况】

*共同第一作者

1. L Wang, M Liu, J Gao, AM Smith, H Fujioka, J Liang, G Perry, X Wang (2021) Mitochondrial Fusion Suppresses Tau Pathology-Induced Neurodegeneration and Cognitive Decline.

Journal of Alzheimer's Disease 84 (3), 1057-1069

2. Ju Gao*, Luwen Wang*, Xiaojia Ren, Justin R Dunn, Ariele Peters, Masaru Miyagi, Hisashi Fujioka, Fangli Zhao, Candice Askwith, Jingjing Liang, Xinglong Wang (2021) Translational regulation in the brain by TDP-43 phase separation.

Journal of Cell Biology 220 (10), e202101019. *co-first author

3. Termsarasab P, Thammongkolchai T, Gao J, Wang L, Liang J, Wang X. (2020) Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice. Experimental Biology and Medicine 0: 1-10.

4. Yan T*, Liang J*, Gao J*, Wang L*, Fujioka H, Zhu X, Wang X. (2020) FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease. Nature Communications 11 (1), 1-16. *co-first author (IF=14.919)

5. Gao J*, Wang L*, Gao C*, Arakawa H, Perry G, Wang X. (2020) TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. BBA-Molecular Basis of Disease 1866 (2020) 165580, *co-first author

6. Gao J, Wang L, Yan T. Perry G, Wang X. (2019) TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration. Mol Cell Neurosci. 100: e103396

7. Liu M, Wang L, Gao J, Dong Q, Perry G, Ma X, Wang X. (2019) Inhibition of Calpain Protects Against Tauopathy in Transgenic P301S Tau Mice. J Alzheimers Dis. 69(4): 1077-1087.

8. Huntley M.L, Gao J, Termsarasab P, Wang L, Zeng S, Thammongkolchai T, Liu Y, Cohen M.L, Wang X. (2019) Association between TDP-43 and mitochondria in inclusion body myositis. Lab Investiga. 99: 1041-1048

9. Xu R, Wang Z, Lu M, Zhang Y, Ji W, Lei L, Wang W, Fang L, Wang L, Yu F, Wang J, Li Z, Wang J, Wang T, Dou F, Wang Q, Wang X, Li S, Ma Q. (2019) Disrupted‐in‐schizophrenia‐1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor. Aging cell. 18(1) e12860.

10. Wang, L., Gao, J., Liu, J., Siedlak, S.L., Torres, S., Fujioka, H., Huntley, M.L., Jiang, Y., Ji, H., Yan, T., Harland, M., Termsarasab, P., Zeng, S., Jiang, Z., Liang, J., Perry, G., Hoppel, C., Zhang, C., Li, H. and Wang, X. (2018) Mitofusion 2 regulates slow axonal transport of calpastatin to prevent programed neuromuscular synaptic elimination in skeletal muscles. Cell Metab. 28 (2) 400-414. e8.(IF=27.287)

11. Gao, J., Wang, L., Huntley, M.L., Perry, G. and Wang, X. (2018) Pathomechanisms of TDP-43 in neurodegeneration. J Neurochem. 146(1) 7-20.

12. Yan, T., Wang, L., Gao, J., Siedlak, S.L., Huntley, M.L., Termsarasab, P., Perry, G., Chen, S.G. and Wang, X. (2018) Rab10 Phosphorylation Is a Prominent Pathological Feature in Alzheimer’s Disease. J Alzheimers Dis. 63(1):157-165.

13. Siedlak, S.L., Jiang, Y., Huntley, M.L., Wang, L., Gao, J., Xie, Fei., Liu, J., Su, B., Perry, G. and Wang, X. (2017) TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer’s Disease. J Alzheimers Dis. 58(4):1027-1033.

14. Wang, W*., Arakawa, H*., Wang, L*., Okolo, O., Siedlak, S.L., Jiang, Y., Gao, J., Xie, F., Petersen, R.B. and Wang, X. (2017) Motor coordination and cognitive dysfunction caused by mutant TDP-43 could be reversed by inhibiting its mitochondrial localization. Mol Ther. 25(1):127-139. *co-first author (IF=11.454)

15. Gao, J., Wang, L., Liu, J., Xie, F., Su, B. and Wang, X. (2017) Abnormalities of mitochondrial dynamics in neurodegenerative diseases. Antioxidants. 6, 25.

16. Wang, W*., Wang, L*., Lu, J*., Siedlak, S.L., Fujiok, H., Liang, J., Jiang, S., Ma, X., Zhen, J., Rocha, E.L., Sheng, M., Choi, H., Lerou, P.H., Li, H., and Wang, X. (2016). The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity. Nat Med. 22(8):869-878. *co-first author

(IF=53.44)

17. Wang, L., Jiang, N., Fang, O., Leach, L.J., Hu, X. and Luo, Z. (2014) 3' Untranslated regions mediate transcriptional interference between convergent genes both locally and ectopically in Saccharomyces cerevisiae. Plos Genet 2, 10(1):e1004021.

18. Jiang, N., Wang, L., Chen, J., Wang, L., Leach, L. and Luo, Z. (2014) Conserved and divergent patterns of DNA methylation in higher vertebrates. Genome Biol Evol 2014, 6(11):2998-3014.

19. Li, J., Wang, L., Wu, X., Fang, O., Wang, L., Lu, C., Yang, S., Hu, X. and Luo, Z. (2013) Polygenic molecular architecture underlying non-sexual cell aggregation in budding yeast. DNA Research 20(1):55-66

联系方式：

luwenw@sdu.edu.cn