郭璐璐，教授，博士生导师。中国科协青年人才托举工程项目获得者，山东省泰山学者青年专家，山东大学“齐鲁青年学者”。长期从事GPCR药理学方向研究，聚焦于嗅觉及鼻科相关疾病中重要GPCR配体识别及激活机制的研究，并进行相关疾病的药物开发。在Nature（2023a, 2023b, 2021, 2020），Science (2025), Cell (2025), Advanced Science (2024), Molecular Cell (2025), Nature Communications (2023), Journal of Neurochemistry (2019)等杂志发表高水平论文十余篇。关于嗅觉受体的研究获“2023年中国科技十大进展新闻”和“2023年中国高校十大科技进展”；关于胆汁酸受体的研究获 “山东大学重大科技成果奖”；曾获“山东省青年药理学先进工作者特等奖”；担任中国认知科学学会化学感知分会委员、中国药理学会生化与分子药理学专业委员会委员、山东省医师协会耳鼻咽喉科医师分会委员、Sensory Neuroscience期刊青年编委等。

教育及工作经历

2024/1 - 至今， 山东大学高等医学研究院 教授

2022/10 - 2023/12， 山东大学高等医学研究院 研究员

2019/9 - 2022/6， 山东大学基础医学院 生物化学与分子生物学系 博士

代表性论著

1. Wenwen Qi#, Chengcheng Liu#, Lei Shi#, Hui Li#, Xiaozhi Hou, Hongjie Du, Luqiu Chen, Xiaochen Gao, Xue Cao, Na Guo, Yuhan Dong, Chengzhilin Li, Fanyu Yuan, Zhenxiao Teng, Houyang Hu, Fangyuan Zhu, Xuanchen Zhou, Lulu Guo*, Miaoqing Zhao*, Ming Xia*.CD169+ Macrophages Mediate the Immune Response of Allergic Rhinitis Through the Keap1/Nrf2/HO-1 Axis. Adv Sci. 2024 Dec;11(45):e2309331.

2. Lulu Guo^#, Jie Cheng^#, Shuo Lian^#, Qun Liu^#, Yan Lu^#, Yuan Zheng^#, Kongkai Zhu^#, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu*, Fan Yang*, Qian Li*, Jin-Peng Sun*. Structural basis of amine odorant perception by a mammalian olfactory receptor. Nature. 2023 May;618:193-200.

3. Zheng Xu^#, Lulu Guo^#, Jingjing Yu^#, Siyuan Shen^#, Chao Wu^#, Weifeng Zhang^#, Chang Zhao^#, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Shengyong Yang, Fan Yang, Xiaohui Wang, Xiao Yu*, Yunfei Xu*, Jin-Peng Sun*, Wei Yan*, Zhenhua Shao*. Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature. 2023 Dec;624(7992):672-681.

4.  Fan Yang^#, Lulu Guo^#, Yu Li^#, Guo-Peng Wang^#, Jia Wang^#, Chao Zhang^#, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan，Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao*, Jin-Peng Sun*. Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec; 600(7887):164-169.

5.  Lulu Guo^#, Yumu Zhang^#, Guoxing Fang^#, Lu Tie^#, Yuming Zhuang^#, Chenyang Xue^#, Qi Liu^#, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou* , Zhongmin Liu *, Fan Yang*, H. Eric Xu* & Jin-Peng Sun*. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nature Communications.2023 Aug;14:5004

6.  Lulu Guo^#, Kongkai Zhu^#, Ya-Ni Zhong^#, Mingxin Gao^#, Junyan Liu^#, Zhimin Qi^#, Zili Liu^#, Naikang Rong, Minghui Zhang, Dongfang Li, Qiyue Zhang, Gongming Yang, Xinxin Zhang, Mingyue Zhang, Ning Ding, Yu-qi Ping, Zhao Yang, Peng Xiao, Ming Xia*, Xiao Yu*, Alatan Gaole*, Jin-Peng Sun*, Fan Yang*. Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement. Mol Cell. 2025 Apr 17;85(8):1658-1673.e7.

7.  Fan Yang^#, Chunyou Mao^#, Lulu Guo^#, Jingyu Lin^#, Qianqian Ming^#, Peng Xiao^#, Xiang Wu^#, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun*, Xin Xie*, Xiao Yu*, Yan Zhang*. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov; 587(7834):499-504.

8. Hui Lin^#, Chuanshun Ma^#, Kui Cai^#, Lulu Guo^#, Xuemei Wang^#, Lin Lv^#, Chao Zhang^#, Jun Lin^#, Daolai Zhang, Chuan Ye, Tengwei Wang, Shenming Huang, Jifei Han, Zihao Zhang, Junyan Gao, Mingxiang Zhang, Zhao Pu, Fengyang Li, Yongyuan Guo, Xiaojun Zhou, Chengxue Qin, Fan Yi, Xiao Yu*, Wei Kong*, Changtao Jiang*, and Jin-Peng Sun*. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025, 388(6746): eado4188.

9.  Xin Wen^#, Pan Shang^#, Haidi Chen^#, Lulu Guo^#, Naikang Rong^#, Xiaoyu Jiang^#, Xuan Li^#, Junyan Liu^#, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi*, Pengju Zhang*, Fan Yang*, Cheng Deng*, Jin-Peng Sun*. Evolutionary study and structural basis of proton sensing by Mus GPR4 andXenopus GPR4. Cell. 2025 Feb 6;188(3):653-670.e24.

10. Meisam Rostaminasab Dolatabad^#, Lulu Guo ^#, Peng Xiao^#, Zhongliang Zhu, Qing-Tao He, Du-Xiao Yang, Chang-Xiu Qu, Sheng-Chao Guo, Xiao-Lei Fu, Rui-Rui Li, Lin Ge, Ke-Jia Hu, Hong-da Liu, Yue-Mao Shen, Xiao Yu, Jin-Peng Sun*, Peng-Ju Zhang*. Crystal structure and catalytic activity of the PPM1K N94K mutant. Journal of Neurochemistry. 2019 Feb; 148(4):550-560.

主持科研项目

1. 国家自然科学基金青年项目：靶向痒觉受体MRGPRX1治疗特应性皮炎的偏好性配体开发，主持

2. 卫健委科技创新2030 ：胰岛新型调控网络在糖脂代谢紊乱发生发展中的作用和机理，课题组长。

3. 科技部重点研发计划：危重出凝血疾病致病新机制及精准诊治研究，课题骨干。

4. 山东省自然科学基金项目：痒觉受体MRGPRX1的配体识别及药物开发，主持。

联系方式：guolu_gl@126.com lulu_guo@sdu.edu.cn