研究方向

从事膜受体GPCR药理学方向研究，聚焦于感知系统GPCR的配体识别及激活机制的研究，并进行相关疾病的药物开发。

教育经历

2022/10-至今，  山东大学高等医学研究院  研究员

2019/9 – 2022/6，山东大学基础医学院生物化学与分子生物学系  博士

代表性论著：

1. Lulu Guo^#, Jie Cheng^#, Shuo Lian^#, Qun Liu^#, Yan Lu^#, Yuan Zheng^#, Kongkai Zhu^#, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu*, Fan Yang*, Qian Li*, Jin-Peng Sun*. Structural basis of amine odorant perception by a mammalian olfactory receptor. Nature. 2023 May;618:193-200.

2.  Fan Yang^#, Lulu Guo^#, Yu Li^#, Guo-Peng Wang^#, Jia Wang^#, Chao Zhang^#, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan，Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao*, Jin-Peng Sun*. Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec; 600(7887):164-169.

3. Lulu Guo^#, Yumu Zhang^#, Guoxing Fang^#, Lu Tie^#, Yuming Zhuang^#, Chenyang Xue^#, Qi Liu^#, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou* , Zhongmin Liu *, Fan Yang*, H. Eric Xu* & Jin-Peng Sun*. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nature Communications.2023 Aug;14:5004

4.  Fan Yang#, Chunyou Mao#, Lulu Guo#, Jingyu Lin#, Qianqian Ming#, Peng Xiao#, Xiang Wu#, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun*, Xin Xie*, Xiao Yu*, Yan Zhang*. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov; 587(7834):499-504.

5.  Meisam Rostaminasab Dolatabad#, Lulu Guo#, Peng Xiao#, Zhongliang Zhu, Qing-Tao He, Du-Xiao Yang, Chang-Xiu Qu, Sheng-Chao Guo, Xiao-Lei Fu, Rui-Rui Li, Lin Ge, Ke-Jia Hu, Hong-da Liu, Yue-Mao Shen, Xiao Yu, Jin-Peng Sun*, Peng-Ju Zhang*. Crystal structure and catalytic activity of the PPM1K N94K mutant. Journal of Neurochemistry. 2019 Feb; 148(4):550-560.

主持科研项目：

国家自然科学基金青年项目：靶向痒觉受体MRGPRX1治疗特应性皮炎的偏好性配体开发，主持

山东省自然科学基金项目：痒觉受体MRGPRX1的配体识别及药物开发，主持

联系方式：guolu_gl@126.com，lulu_guo@sdu.edu.cn