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袁佳
作者:  来源:  发布时间:2020年05月08日 09:04  浏览次数:




研究领域:


主要关注妊娠过程中的母胎对话机制。妊娠是一个极其复杂的生理过程,根据母体子宫在妊娠期间的状态,可以大体分为容受期,植入期,蜕膜化期,胎盘期以及分娩期,每一时期都对妊娠成功至关重要,然而,胚胎与母体子宫之间如何建立对话以及子宫如何保证胎儿在其中健康发育依然不明。本实验室以子宫特异性敲除小鼠为研究对象,关注妊娠早期胚胎植入和蜕膜化发生的分子机理,以及妊娠相关的疾病,如流产,早产等。


学习与工作经历:

2003-2007 四川农业大学 学士

2007-2013 武汉大学 博士

2014-2019 美国辛辛那提儿童医院医学中心 博士后

2020 至今: 山东大学高等医学研究院 教授


发表文章:

#共同第一作者,*通讯作者

1.      J. Yuan, Y. Zhang, Y. Sheng, X. Fu, H. Cheng*, R. Zhou*, MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Autophagy 11, 1081-1098 (2015).

2.           J. Yuan#, J. Cha#, W. Deng, A. Bartos, X. Sun, H. H. Ho, J. P. Borg, T. P. Yamaguchi, Y. Yang, S. K. Dey*, Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. Proceedings of the National Academy of Sciences of the United States of America 113, E8079-E8088 (2016).

3.           J. Yuan#, W. Deng#, J. Cha, X. Sun, J. P. Borg, S. K. Dey*, Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nature communications 9, 603 (2018).

4.      J. Yuan#, S. Aikawa#, W. Deng#, A. Bartos, G..Walz, F. Grahammer, T.B. Huber, X.Sun, S.K. Dey*, Primary decidual zone formation requires Scribble for pregnancy success in mice. Nature communications, 10:5425, (2019) .

5.      Deng W#, Yuan J#, Cha J, Sun X, Bartos A, Yagita H, Hirota Y, Dey SK*. Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention. Cell reports, 7;27(6):1755-1768.e4, (2019).

6.      S. Aikawa, J. Yuan, A. Dewer, X. Sun, S. K. Dey* Scribble promotes alveologenesis in the pregnant mammary gland for milk production. Reproduction, 2020, 3(1)

7.     S. Aikawa#, W. Deng#, X. Liang, J. Yuan, A. Bartos, X. Sun, S. K. Dey*, Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes. Cell death and differentiation, (2019).

8.            K. D. Duncan, R. Fang, J. Yuan, R. K. Chu, S. K. Dey, K. E. Burnum-Johnson, I. Lanekoff*, Quantitative Mass Spectrometry Imaging of Prostaglandins as Silver Ion Adducts with Nanospray Desorption Electrospray Ionization. Analytical chemistry,  (2018).

9.            W. Deng#, J. Cha#, J. Yuan, H. Haraguchi, A. Bartos, E. Leishman, B. Viollet, H. B. Bradshaw, Y. Hirota, S. K. Dey*, p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest 126, 2941-2954 (2016).

10.         X. Fu, Y. Cheng, J. Yuan, C. Huang, H. Cheng, R. Zhou, Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum Genet 134, 147-158 (2015).

11.          K. Chen, C. Huang, J. Yuan, H. Cheng, R. Zhou, Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol 31, 2194-2211 (2014).

12.         Y. Hou, J. Yuan, X. Zhou, X. Fu, H. Cheng, R. Zhou, DNA demethylation and USF regulate the meiosis-specific expression of the mouse Miwi. PLoS Genet 8, e1002716 (2012).

13.         Y. Hou, X. Zhou, J. Liu, J. Yuan, H. Cheng, R. Zhou, Nuclear factor-Y (NF-Y) regulates transcription of mouse Dmrt7 gene by binding to tandem CCAAT boxes in its proximal promoter. Int J Biol Sci 6, 655-664 (2010).


联系方式:

jia.yuan@sdu.edu.cn


 
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